TNF-alpha NF-kB signaling pathway (Mus musculus)

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EndosomeEndoplasmic reticulum(Protein-protein interaction)ERRecruitmentDeacetylationDemethylationProteolytic cleavageProteins in a complex interactionDesumoylationENCY ->NUInhibitionCY ->NUEnzyme complexDDeubiquitinationMitochondrionLigandPMAccession Number: NetPath 9; cellmap:9AcetylationGolgi apparatusTranslocationCY ->NUCytoplasmMolecular associationMolecule in the pathwayGlycosylationUbiquitinationCY ->NUControlPalmitoylationMethylationMTNUECGOReceptorSumoylationExtracellularReaction through unknown mechanisms/moleculesCY ->NUAutophosphorylationDephosphorylationPlasma membraneNucleusActivationPhosphorylationCYDdx3xG3bp2TxlnaCasp7CraddYwhazNr2c2RelTnfrsf1bRasal2Tnfrsf11aBcl3RelaMap3k7ip1Traf5Hsp90ab1Mtif2Birc2TankFancd2RPL30NfkbieGnb2l1Gene SymbolSmarcc1ChukCdc37Traf4Map2k5Gm4596RPL6NfkbiaCasp8ap2Traf3Polr1dKpna6Nfkb1Nfkb2FblRPS6KB1Ptk2Ppp2caPolr1aTnfYwhaeCommd1Smarce1Cul1Cdc34Faf1NfkbiaGeneCapn3Psmd13AlplHdac1Pdcd2Polr1eTraf4Hsp90aa1Tnip1Nkiras2Psmd7Traf1Pkn1GeneMcm5LrpprcFlnaIkbkgIkbkgRipk2Bag4Tbk1PrkacaRelbCasp2Map3k2Ripk1TnfTnfrsf1aMap3k1Nfkb1Peg3Ripk3Akt2Kpna3ChukPolr1cCflarRPS13IkbkeHdac6Pias32610301G19RikTnip2YwhagTifaTraf6Psmc3GeneRipk1YwhabGsk3bRpl4Casp3Map3k8Pfdn2NsmafGab1Csnk2bNlrp4eNfkbiaFbxw11Psmb5Map3k14CyldCASP10KPNA2FaddIqgap2Psmd6Psmc1TnfKcnq1Csnk2a2Akt1IkbkapTrpc4apBirc2RelaTnfMark2Gm2423Nkiras1Traf2Smarca4Eif4a3Map3k3PrkczGlg1IkbkbTnfrsf1aTnfrsf1bHdac2Map3k7ip3BCL7ACrebbpTraf1Cops3MCCPapolaTnfUsp11Map3k3RelbGtf2iMcm7Tnfrsf8Rps6ka5Ptpn11CSNK2A1Pebp1Usp2Wdr68DapSmarcc2RelaBirc3Ktn1Azi2Rnf216HIST3H3SrcTraipRps11Dpf2Zfand5Psmd3Cav1Rnf25TraddSKP1ATraf2SUMO1Actl6aCd3eapBirc3YwhahTraf2Ube2iGenePpp1r13lTnfNfkbizCasp8Stat1Polr1bMap3k7ip2RelTnfrsf1aPolr2hPsmc2Nfkb1NfkbibTraddSmarcb1Hspb1Psmd1Akap8PmlRelaGm10774Nr2c2Psmd12RPL8Tbk1Unc5clTnfrsf1bFkbp5Tnfaip3BtrcUBCH5B


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 91% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118927view14:51, 4 June 2021EgonwModified description
118924view11:15, 4 June 2021Mkutmonupdate description
118923view11:15, 4 June 2021Mkutmonupdate description
116715view09:56, 11 May 2021EweitzModified title
69201view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67701view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41391view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34428view23:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32375view16:51, 15 August 2009MaintBotFixed text labels
32011view13:20, 14 August 2009MaintBotFixed group labels
31412view20:54, 13 August 2009MaintBotFixed text labels
30882view00:17, 30 July 2009MaintBotConverted from Homo sapiens
21197view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP246]]: Moved to stable identifier
8448view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7840view16:22, 18 December 2007MaintBotfixed category names
7308view12:42, 4 November 2007MaintBotAdded categories to GPML
6503view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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CASP10GeneProduct
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Casp8ap2GeneProduct26885 (Entrez Gene)
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UBCH5BGeneProduct
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YwhazGeneProduct22631 (Entrez Gene)
Zfand5GeneProduct22682 (Entrez Gene)

Annotated Interactions

No annotated interactions
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