Transforming growth factor (TGF) beta receptor signaling (Pan troglodytes)

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GlycosylationPMNUEnzyme complexCYControlMolecular associationReceptorNUNUNUNUProteolytic cleavageNUMTCYNUAutophosphorylationCYCYNUNUDephosphorylationLigandEC(Protein-protein interaction)NUAcetylationCytoplasmNUMolecule in the pathwayInhibitionRecruitmentPalmitoylationEndoplasmic reticulumNUCYNUCYCYCYNUSumoylationERReaction through unknown mechanisms/moleculesCYCYCYNUNUPhosphorylationNUCYCYCYGlycosylationNUCYNUDeacetylationActivationCYNUCYUbiquitinationMethylationExtracellularNUNUCYMitochondriaNU -> CYCYAccession Number: NetPath 7; cellmap:7Golgi apparatusNUDesumoylationNucleusNU -> CYCYCYNUNUPlasma membraneCYDProteins in a complex interactionDemethylationENEndosomeGOTranslocationCYCYCYCYCYDeubiquitinationNUNUYAP1STAMBPL1CDC25AANAPC5TGFBR2ANAPC4SMURF1RBL1PIK3R2SMAD4SMAD7CCND1TGFB3TFDP1ANAPC2NUP153CAMK2ATGFB1LOC464259FOXH1RB1ROCK1STK11MEF2CTFDP2TGFBR2SMAD2CTNNB1SMAD4CDC27NFYCSMAD3BTRCTGFBR3E2F4BTRCSMAD3ARRB2NUP214PRKAR1BSP1RBX1SKP1PRKAR2ACTCFXPO1TGFBR3CDC16CCNE1UBE2D1TGFBR3GIPC1PIAS2RBL1TGFBR3TGFB3RBL2ANAPC7JUNBPRKCDFOSBDAB2EP300LEF1TGFBR2RB1TGFBR1SMAD3CCNB2KPNB1E2F4DVL1RBL1PIK3R1FOXG1BHOXA9SMAD3TGFBR1ATF2SMAD4TGFB2SNX6ATF3CUL1ESR1E2F4CDC27MAP3K7IP1TGFBR2RUNX2CUL1ANAPC4TCF8MAP2K6RBX1CAMK2BE2F5SMAD2AP2B1FOXO3AMAP2K3SMAD2SUMO1CDC23SNX2TGFBR2FOXO1HNF4AMAPK8TGIF1TGFB1MAPK14SNX1CDC2STK11IPMYCSNIP1SNW1CDK2PPP2R2ARBL1STRAPTGFBR2TGFBR3ANAPC2MAP3K7UBE2D3PERBB2IPNFYASKILE2F4TFDP2COPS5SMURF2PIAS1CAMK2DJUNDEIF3S2SMAD3HGSSTRAPDAXXCAMK2GE2F5TGFB2E2F5SMAD4AXIN2CDC16ETS1TFDP2KPNB1CREBBPTGFB3RB1MEF2ATGFB2SMAD3SDC2TGFBR2CRI2ENGTGFB1E2F5TP53FOSSMAD4SMAD2APC10APC10TP73SMAD4AXIN1CDK6CDC27FZR1FNTAKAT2BPRKCB1TFDP1E2F5TGFB1ESR1FKBP1AMAPK14ANAPC1CUL1SMAD7ANAPC1ACVRL1CDC23TFDP1UBE2D2HSPA8Gene SymbolROCK1SMAD6SNX6TGFBR1CDK4TGFBR2ARCAV1DCP1ATGFBR1RBX1MAPK8RBL2SMAD3ZFYVE9E2F4DCP1ATGFBR3FOXO4CDKN1ACD44JUNNFYBSPARCSMURF2CITED1SMAD7TGFB3ZEB2SMURF1SKP1SMAD3NCOA1VDRPRKCGPARD3ANAPC7TRAP1E2F4SMAD3SNX4TGFBR2SKIRBL1E2F5ANAPC5TGFBR2


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 88% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
129686view00:47, 22 May 2024EweitzModified title
118021view11:36, 23 May 2021EweitzModified title
87746view09:48, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87744view09:47, 25 July 2016MirellaKalafatiModified title
69312view18:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
41622view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34350view22:22, 9 December 2009MaintBotAutomatic update of empty xrefs
31603view22:09, 13 August 2009MaintBotFixed text labels
30495view21:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVRL1GeneProduct451910 (Entrez Gene)
ANAPC1GeneProduct735949 (Entrez Gene)
ANAPC2GeneProduct465174 (Entrez Gene)
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ANAPC5GeneProduct452321 (Entrez Gene)
ANAPC7GeneProduct467128 (Entrez Gene)
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APC10GeneProduct
ARGeneProduct747460 (Entrez Gene)
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ATF2GeneProduct
ATF3GeneProduct469143 (Entrez Gene)
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AXIN2GeneProduct468301 (Entrez Gene)
BTRCGeneProduct450685 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct461445 (Entrez Gene)
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CAV1GeneProduct463670 (Entrez Gene)
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CCNE1GeneProduct455914 (Entrez Gene)
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CDC23GeneProduct462092 (Entrez Gene)
CDC2GeneProduct450481 (Entrez Gene)
CDC25AGeneProduct460341 (Entrez Gene)
CDC27GeneProduct454815 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene)
CDK4GeneProduct452025 (Entrez Gene)
CDK6GeneProduct746968 (Entrez Gene)
CDKN1AGeneProduct747442 (Entrez Gene)
CITED1GeneProduct465711 (Entrez Gene)
COPS5GeneProduct744682 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
CRI2GeneProduct
CTCFGeneProduct454169 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
CUL1GeneProduct463821 (Entrez Gene)
DAB2GeneProduct461905 (Entrez Gene)
DAXXGeneProduct462613 (Entrez Gene)
DCP1AGeneProduct460444 (Entrez Gene)
DVL1GeneProduct457191 (Entrez Gene)
E2F4GeneProduct454158 (Entrez Gene)
E2F5GeneProduct747256 (Entrez Gene)
EIF3S2GeneProduct
ENGGeneProduct741046 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
ERBB2IPGeneProduct471527 (Entrez Gene)
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ETS1GeneProduct
FKBP1AGeneProduct749347 (Entrez Gene)
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FOSGeneProduct453047 (Entrez Gene)
FOSBGeneProduct456127 (Entrez Gene)
FOXG1BGeneProduct
FOXH1GeneProduct464468 (Entrez Gene)
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FOXO3AGeneProduct
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FZR1GeneProduct
GIPC1GeneProduct747668 (Entrez Gene)
Gene SymbolGeneProduct
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HNF4AGeneProduct458269 (Entrez Gene)
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JUNDGeneProduct748667 (Entrez Gene)
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LEF1GeneProduct461425 (Entrez Gene)
LOC464259GeneProduct464259 (Entrez Gene)
MAP2K3GeneProduct454515 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAP3K7IP1GeneProduct458845 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
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MYCGeneProduct464393 (Entrez Gene)
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NFYCGeneProduct456799 (Entrez Gene)
NUP153GeneProduct462455 (Entrez Gene)
NUP214GeneProduct464807 (Entrez Gene)
PARD3GeneProduct450398 (Entrez Gene)
PIAS1GeneProduct467715 (Entrez Gene)
PIAS2GeneProduct455403 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PPP2R2AGeneProduct464068 (Entrez Gene)
PRKAR1BGeneProduct
PRKAR2AGeneProduct
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
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RBL1GeneProduct735916 (Entrez Gene)
RBL2GeneProduct467978 (Entrez Gene)
RBX1GeneProduct458860 (Entrez Gene)
ROCK1GeneProduct455326 (Entrez Gene)
RUNX2GeneProduct472017 (Entrez Gene)
SDC2GeneProduct
SKIGeneProduct
SKILGeneProduct460844 (Entrez Gene)
SKP1GeneProduct462063 (Entrez Gene)
SMAD2GeneProduct455407 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SMAD4GeneProduct468537 (Entrez Gene)
SMAD6GeneProduct467711 (Entrez Gene)
SMAD7GeneProduct455411 (Entrez Gene)
SMURF1GeneProduct472670 (Entrez Gene)
SMURF2GeneProduct454761 (Entrez Gene)
SNIP1GeneProduct456759 (Entrez Gene)
SNW1GeneProduct453073 (Entrez Gene)
SNX1GeneProduct453503 (Entrez Gene)
SNX2GeneProduct462022 (Entrez Gene)
SNX4GeneProduct460652 (Entrez Gene)
SNX6GeneProduct467421 (Entrez Gene)
SP1GeneProduct451939 (Entrez Gene)
SPARCGeneProduct471709 (Entrez Gene)
STAMBPL1GeneProduct466147 (Entrez Gene)
STK11GeneProduct468641 (Entrez Gene)
STK11IPGeneProduct459968 (Entrez Gene)
STRAPGeneProduct465315 (Entrez Gene)
SUMO1GeneProduct459882 (Entrez Gene)
TCF8GeneProduct
TFDP1GeneProduct465967 (Entrez Gene)
TFDP2GeneProduct460743 (Entrez Gene)
TGFB1GeneProduct456060 (Entrez Gene)
TGFB2GeneProduct457742 (Entrez Gene)
TGFB3GeneProduct453054 (Entrez Gene)
TGFBR1GeneProduct472992 (Entrez Gene)
TGFBR2GeneProduct460243 (Entrez Gene)
TGFBR3GeneProduct457016 (Entrez Gene)
TGIF1GeneProduct455312 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
TP73GeneProduct
TRAP1GeneProduct453868 (Entrez Gene)
UBE2D1GeneProduct745141 (Entrez Gene)
UBE2D2GeneProduct462108 (Entrez Gene)
UBE2D3PGeneProduct745118 (Entrez Gene)
VDRGeneProduct
XPO1GeneProduct459534 (Entrez Gene)
YAP1GeneProduct451506 (Entrez Gene)
ZEB2GeneProduct459644 (Entrez Gene)
ZFYVE9GeneProduct456855 (Entrez Gene)

Annotated Interactions

No annotated interactions
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