Senescence and autophagy (Rattus norvegicus)

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Description

Senescense and Autophagy Pathways in Cancer

Comments

HomologyConvert: This pathway was inferred from Homo sapiens pathway WP615(r29697) with a 92% conversion rate.

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Ontology Terms

Bibliography

Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; Cell, 2008 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
117009	view	11:21, 16 May 2021	Eweitz	Modified title
86844	view	14:52, 13 July 2016	Mkutmon	Ontology Term : 'cellular senescence pathway' added !
86843	view	14:52, 13 July 2016	Mkutmon	Ontology Term : 'PW:0000277' removed !
72036	view	13:30, 24 October 2013	Susan	Annotation and connected lines
71771	view	20:30, 17 October 2013	MaintBot	Automated update of data sources
69337	view	18:51, 8 July 2013	MaintBot	Updated to 2013 gpml schema
67636	view	11:36, 26 June 2013	Ddigles	Ontology Term : 'senescence pathway' added !
48390	view	22:37, 23 May 2012	Khanspers	updated xrefs
47752	view	04:20, 6 April 2012	Khanspers	updated xrefs
47751	view	04:11, 6 April 2012	Khanspers	Periodical save, work in progress
41649	view	02:34, 2 March 2011	MaintBot	Removed redundant pathway information and comments
34050	view	19:02, 9 December 2009	MaintBot	Automatic update of empty xrefs
32757	view	23:38, 3 September 2009	MaintBot	Modified categories
31901	view	12:47, 14 August 2009	MaintBot	Fixed group labels
30999	view	01:00, 30 July 2009	MaintBot	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ATG16	GeneProduct
ATG5	GeneProduct	365601 (Entrez Gene)
Atg7	GeneProduct	312647 (Entrez Gene)
Becn1	GeneProduct	114558 (Entrez Gene)
Bmi1	GeneProduct	307151 (Entrez Gene)	ARF
Bmp2	GeneProduct	29373 (Entrez Gene)	tPA
Braf	GeneProduct	114486 (Entrez Gene)
Cd44	GeneProduct	25406 (Entrez Gene)
Cdc25b	GeneProduct	171103 (Entrez Gene)
Cdkn1a	GeneProduct	114851 (Entrez Gene)	P21/CIP1/WAF1
Cdkn1b	GeneProduct	83571 (Entrez Gene)	P27/KIP
Cdkn2a	GeneProduct	25163 (Entrez Gene)	ARF
Cebpb	GeneProduct	24253 (Entrez Gene)
Col1a1	GeneProduct	29393 (Entrez Gene)
Creg1	GeneProduct	289185 (Entrez Gene)
Cxcl14	GeneProduct	306748 (Entrez Gene)	BRAK
Cxcl3	GeneProduct	171551 (Entrez Gene)	GROa
E2f1	GeneProduct	399489 (Entrez Gene)
Fn1	GeneProduct	25661 (Entrez Gene)
GAS	GeneProduct		DNA regulatory element
GeneProduct	GeneProduct
Gsk3b	GeneProduct	84027 (Entrez Gene)
Gsn	GeneProduct	296654 (Entrez Gene)
Gstt2	GeneProduct	29487 (Entrez Gene)
Hras	GeneProduct	293621 (Entrez Gene)	H-RAS
IFI16	GeneProduct
IL3	GeneProduct	24495 (Entrez Gene)
IL8	GeneProduct
ISRE	GeneProduct		DNA regulatory element
Ifnb1	GeneProduct	24481 (Entrez Gene)
Ifng	GeneProduct	25712 (Entrez Gene)
Igf1	GeneProduct	24482 (Entrez Gene)
Igf1r	GeneProduct	25718 (Entrez Gene)
Igfbp5	GeneProduct	25285 (Entrez Gene)
Igfbp7	GeneProduct	289560 (Entrez Gene)	ARF
Il6	GeneProduct	24498 (Entrez Gene)
Il6ra	GeneProduct	24499 (Entrez Gene)
Il6st	GeneProduct	25205 (Entrez Gene)
Ing1	GeneProduct	306626 (Entrez Gene)
Irf1	GeneProduct	24508 (Entrez Gene)
Irf5	GeneProduct	296953 (Entrez Gene)
Irf7	GeneProduct	293624 (Entrez Gene)
Lamp2	GeneProduct	24944 (Entrez Gene)
Map1lc3a	GeneProduct	362245 (Entrez Gene)
Map2k1	GeneProduct	170851 (Entrez Gene)	MEK
Map2k3	GeneProduct	303200 (Entrez Gene)	MEK6
Mapk1	GeneProduct	116590 (Entrez Gene)	ERK
Mapk14	GeneProduct	81649 (Entrez Gene)	P38a
Mdm2	GeneProduct	314856 (Entrez Gene)
Mll1	GeneProduct	315606 (Entrez Gene)	ARF
Mtor	GeneProduct	56718 (Entrez Gene)	mTOR
Plat	GeneProduct	25692 (Entrez Gene)	tPA
Pten	GeneProduct	50557 (Entrez Gene)
Raf1	GeneProduct	24703 (Entrez Gene)
Rb1	GeneProduct	24708 (Entrez Gene)
Rnasel	GeneProduct	359726 (Entrez Gene)
Serpinb2	GeneProduct	60325 (Entrez Gene)
Serpine1	GeneProduct	24617 (Entrez Gene)	PAI1
Sh3glb1	GeneProduct	292156 (Entrez Gene)	BIF1
Sparc	GeneProduct	24791 (Entrez Gene)
THBS1	GeneProduct	445442 (Entrez Gene)
Tgfb1	GeneProduct	59086 (Entrez Gene)
Tp53	GeneProduct	24842 (Entrez Gene)
Ulk1	GeneProduct	360827 (Entrez Gene)	ATG1
Vtn	GeneProduct	29169 (Entrez Gene)

Annotated Interactions

No annotated interactions

Senescence and autophagy (Rattus norvegicus)

From WikiPathways

Description

Comments

Try the New WikiPathways

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