Integrated breast cancer pathway (Homo sapiens)

From WikiPathways

Revision as of 18:11, 13 July 2011 by Saibrahi (Talk | contribs)
Jump to: navigation, search
8142541619618131017151893711G1MG2SBASC ComplexCell Cycle1, 11, 20BIDTAB1CorticosteroneRHOFADDSTK11BADAKT1RAP1ATSC1CASP9BARD1RALGAPA1ALKB1RAC1NF1C9JNK1ITPKCBAKAnti-ApoptosisPMLBADMAPKsCASP3Cell SurvivalRRASMDM2CDC42ATMUBE2FSP1DHTBMPR2P85AATMBAXRPP38UBIMDAG1CHK2AQP73Lithium ChlorideAmpicillinB5MEC1CBPPPRB/RBDihydrotestosteroneCIP1TranscriptionSMAD1GADD45AMSH6AHRP53JKIP1NCOA2CHK1CASP8RRASBRCA1Penicillin GBRAFRASGEF1ATetradecanoylphorbol AcetateSMAD3RALAMRE11NOXA1ATREstradiolARBMPR1ARAD54LSMAD7TSC1GSK3AWEE1HDAC1MTORCSNK1DCREBVEGFAMMP1UBP15TAK1LFADDUBP21TRADDTFPIP53ANDRCell proliferationXRCC3IKKACycloheximideEGFRB3KP27SIRT1TamoxifenGRNATF1PKCB1CDK4HDAC1KRASE2F1SMEK1MitomycinFlutamideP85TGFR2FOXO1Proliferative genesMSH2NocodazoleCCND1C9JNK1PLK3CADNACERK1SMCA4CDH1CDK7RHEBNCOA3AngiogenesisNFKB1ApoptosisBRCA1JAK1ERKMYCDCAKDCERK1ERC9JNK1PlicamycinE2F1SMAD4JUNEP300CDC25ABCL2CASP3PRMPIP1MYT1PIAS1WEE1ATRAURKAERAL1ATRCell Cycle arrestPLK3GRP13TSC2P13KHDAC1/HDAC2UBP16ANXA1BACH1RHOZMIZ1PLK1MAXPTENMPIP2Cancer DevelopmentSMAD4Cell survival and ProliferationUBP21SELKMethyl MethanesulfonateRaloxifeneSMAD2RRASABC3GCDK2ProteinPHBCDK2DexamethasoneHIPK2AKT1DonepezilP38Gene ExpressionP65IKKABARD1RAD50IRS1SMAD7SMAD6MDM2Q8NBS1CERKRASGRP3STAT1IPKAABL1GCRNAB1FLIP1HydroxyureaApoptosisHydrocortisoneBleomycinRAFTGFR1CTNB1IMPA1PAK1GDISMEK2BLMBRCA2ESR1SMEK1RAD5112


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Muأ±oz E, Courtois G, Veschambre P, Jalinot P, Israأ«l A; ''Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.''; J Virol, 1994 PubMed Europe PMC Scholia
  2. Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW; ''Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.''; J Clin Invest, 1994 PubMed Europe PMC Scholia
  3. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  4. Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B, Balk SP; ''Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  5. Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YM; ''MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN.''; Arch Med Res, 2011 PubMed Europe PMC Scholia
  6. Hall LL, Th'ng JP, Guo XW, Teplitz RL, Bradbury EM; ''A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation.''; Cancer Res, 1996 PubMed Europe PMC Scholia
  7. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
  8. Wang W, Seki M, Narita Y, Sonoda E, Takeda S, Yamada K, Masuko T, Katada T, Enomoto T; ''Possible association of BLM in decreasing DNA double strand breaks during DNA replication.''; EMBO J, 2000 PubMed Europe PMC Scholia
  9. Fritz G, Kaina B; ''Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  10. Su M, Bansal AK, Mantovani R, Sodek J; ''Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  11. ''''; , PubMed Europe PMC Scholia
  12. Zhang M, Lee CH, Luo DD, Krupa A, Fraser D, Phillips A; ''Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  13. Paci C, Gobbato R, Carboni T, Sanguigni S, Santone A, Curatola L; ''P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.''; Neurol Sci, 2006 PubMed Europe PMC Scholia
  14. Persianinov LS; ''The use of electro-analgesia in obstetrics and gynecology. A survey by invitation.''; Acta Obstet Gynecol Scand, 1975 PubMed Europe PMC Scholia
  15. Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH; ''Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  16. Gu RG, Zhou CW, Ma QZ; ''[Effect of dihydrotestosterone on the transcriptions and expressions of Smad3 and Smad4 in LNCaP cell line].''; Zhonghua Nan Ke Xue, 2006 PubMed Europe PMC Scholia
  17. Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, Nakshatri H; ''Estradiol-regulated microRNAs control estradiol response in breast cancer cells.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  18. Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY; ''miR-21-mediated tumor growth.''; Oncogene, 2007 PubMed Europe PMC Scholia
  19. Li YJ, Azuma A, Usuki J, Abe S, Matsuda K, Sunazuka T, Shimizu T, Hirata Y, Inagaki H, Kawada T, Takahashi S, Kudoh S, Omura S; ''EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts.''; Respir Res, 2006 PubMed Europe PMC Scholia
  20. Ray R, Thomas S, Miller DM; ''Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.''; Am J Med Sci, 1990 PubMed Europe PMC Scholia
  21. Terasaki M, Reese TS; ''Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface.''; Cell Motil Cytoskeleton, 1994 PubMed Europe PMC Scholia
  22. Sweezey NB, Ghibu F, Gagnon S, Schotman E, Hamid Q; ''Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  23. Paul R, Dalibart R, Lemoine S, Lestienne P; ''Expression of E. coli RecA targeted to mitochondria of human cells.''; Mutat Res, 2001 PubMed Europe PMC Scholia
  24. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH; ''Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  25. Yu Y, Wang Y, Ren X, Tsuyada A, Li A, Liu LJ, Wang SE; ''Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells.''; Mol Cancer Res, 2010 PubMed Europe PMC Scholia
  26. Ellis D, Sothi TD, Avner ED; ''Glucocorticoids modulate renal glucocorticoid receptors and Na-K ATPase activity.''; Kidney Int, 1987 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126476view20:57, 5 May 2023EgonwAdded an identifier for the proteasome node
123531view06:33, 2 August 2022EgonwMade two pathways clickable
116548view12:47, 7 May 2021EweitzModified title
116285view21:46, 26 April 2021EweitzModified description
113594view09:46, 4 November 2020DeSlUpdated hydrocortisone ID (to drug ID).
110683view13:17, 28 May 2020EgonwAdded missing @Type annotation
108807view15:48, 30 January 2020DeSlReplaced P65 with MAP3K13
108804view15:38, 30 January 2020DeSlUpdated C9JNK1 to ZN655
108802view15:27, 30 January 2020DeSlRemoved B5MEC1; doesn't exist in original database anymore; no replacement; no lit.ref.
108799view15:00, 30 January 2020DeSlUpdated name FOSL2
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot/TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl Human)
AHRGeneProductENSG00000106546 (Ensembl Human)
AKT1ProteinP31749 (Uniprot/TrEMBL)
ALKB1ProteinQ13686 (Uniprot/TrEMBL)
ANDRProteinP10275 (Uniprot/TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl Human)
AQP73ProteinA6NL99 (Uniprot/TrEMBL)
ARProteinQ9UNE0 (Uniprot/TrEMBL)
ATF1ProteinP18846 (Uniprot/TrEMBL)
ATMProteinQ13315 (Uniprot/TrEMBL)
ATRProteinQ13535 (Uniprot/TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl Human)
Ampicillin
Angiogenesis
Anti-Apoptosis
Apoptosis
B3KP27ProteinB3KP27 (Uniprot/TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot/TrEMBL)
BACH1ProteinO14867 (Uniprot/TrEMBL)
BADProteinQ92934 (Uniprot/TrEMBL)
BAKProteinQ16611 (Uniprot/TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl Human)
BAXGeneProductENSG00000087088 (Ensembl Human)
BCL2ProteinP10415 (Uniprot/TrEMBL)
BIDProteinP55957 (Uniprot/TrEMBL)
BLMProteinP54132 (Uniprot/TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl Human)
BMPR2ProteinQ13873 (Uniprot/TrEMBL)
BRAFProteinP15056 (Uniprot/TrEMBL)
BRCA1ProteinP38398 (Uniprot/TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl Human)
Bleomycin
C9JNK1ProteinC9JNK1 (Uniprot/TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CBPGeneProductENSG00000005810 (Ensembl Human)
CCND1ProteinP24385 (Uniprot/TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl Human)
CDH1GeneProductENSG00000039068 (Ensembl Human)
CDK2ProteinP24941 (Uniprot/TrEMBL)
CDK4ProteinP11802 (Uniprot/TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot/TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot/TrEMBL)
CHK2ProteinO96017 (Uniprot/TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot/TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl Human)
CSNK1DGeneProductENSG00000141551 (Ensembl Human)
CTNB1ProteinP35222 (Uniprot/TrEMBL)
Cancer Development
Cell Cycle arrest
Cell Survival
Cell proliferation
Cell survival and Proliferation
Corticosterone
Cycloheximide
DAG1GeneProductENSG00000173402 (Ensembl Human)
DCAKDProteinQ8WVC6 (Uniprot/TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl Human)
DNA
Dexamethasone
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
Donepezil
E2F1GeneProduct1869 (Entrez Gene)
E2F1ProteinQ01094 (Uniprot/TrEMBL)
EGFRProteinP00533 (Uniprot/TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl Human)
ERAL1GeneProductENSG00000132591 (Ensembl Human)
ERKGeneProduct64781 (Entrez Gene)
ERProteinP16591 (Uniprot/TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl Human)
Estradiol
FADDGeneProductENSG00000168040 (Ensembl Human)
FADDProteinQ13158 (Uniprot/TrEMBL)
FLIP1ProteinQ7Z7B0 (Uniprot/TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl Human)
Flutamide
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GCRGeneProductENSG00000113161 (Ensembl Human)
GDIGeneProduct2664 (Entrez Gene)
GR ProteinP01833 (Uniprot/TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl Human)
GSK3AProteinP49840 (Uniprot/TrEMBL)
Gene Expression
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl Human)
HDAC1ProteinQ13547 (Uniprot/TrEMBL)
HDAC1Protein
HIPK2ProteinQ9H2X6 (Uniprot/TrEMBL)
Hydrocortisone
Hydroxyurea
IKKAProteinO15111 (Uniprot/TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl Human)
IPKAProteinP61925 (Uniprot/TrEMBL)
IRS1GeneProductENSG00000169047 (Ensembl Human)
ITPKCGeneProductENSG00000086544 (Ensembl Human)
JAK1ProteinP23458 (Uniprot/TrEMBL)
JKIP1ProteinQ96N16 (Uniprot/TrEMBL)
JUNGeneProductENSG00000177606 (Ensembl Human)
KRASGeneProductENSG00000133703 (Ensembl Human)
Lithium Chloride
MAPKsGeneProduct5594 (Entrez Gene)
MAXProteinP61244 (Uniprot/TrEMBL)
MDM2ProteinQ00987 (Uniprot/TrEMBL)
MMP1ProteinP03956 (Uniprot/TrEMBL)
MPIP1ProteinP30304 (Uniprot/TrEMBL)
MPIP2 ProteinP30305 (Uniprot/TrEMBL)
MRE11ProteinP49959 (Uniprot/TrEMBL)
MSH2ProteinP43246 (Uniprot/TrEMBL)
MSH6ProteinP52701 (Uniprot/TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl Human)
MYCProteinP01106 (Uniprot/TrEMBL)
MYT1ProteinQ01538 (Uniprot/TrEMBL)
Methyl Methanesulfonate
Mitomycin
NAB1ProteinQ13506 (Uniprot/TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl Human)
NCOA3GeneProductENSG00000124151 (Ensembl Human)
NF1ProteinP21359 (Uniprot/TrEMBL)
NFKB1 ProteinP19838 (Uniprot/TrEMBL)
NOXA1ProteinQ86UR1 (Uniprot/TrEMBL)
Nocodazole
P13KGeneProductENSG00000229882 (Ensembl Human)
P13ProteinQ9UHV8 (Uniprot/TrEMBL)
P38GeneProduct84640 (Entrez Gene)
P53ProteinP04637 (Uniprot/TrEMBL)
P65 ProteinC9JP65 (Uniprot/TrEMBL)
P85AGeneProductENSG00000125450 (Ensembl Human)
P85ProteinO00459 (Uniprot/TrEMBL)
PAK1ProteinQ13153 (Uniprot/TrEMBL)
PHBGeneProductENSG00000167085 (Ensembl Human)
PIAS1ProteinO75925 (Uniprot/TrEMBL)
PKCB1ProteinQ9ULU4 (Uniprot/TrEMBL)
PLK1ProteinP53350 (Uniprot/TrEMBL)
PLK3CAGeneProduct1263 (Entrez Gene)
PLK3GeneProductENSG00000173846 (Ensembl Human)
PMLProteinP29590 (Uniprot/TrEMBL)
PPRB/RBProteinP06400 (Uniprot/TrEMBL)
PRProteinP12270 (Uniprot/TrEMBL)
PTENProteinP60484 (Uniprot/TrEMBL)
Penicillin G
Plicamycin
Proliferative genes
ProteinProtein
Q8NBS1ProteinQ8NBS1 (Uniprot/TrEMBL)
RAC1ProteinP63000 (Uniprot/TrEMBL)
RAD50ProteinQ92878 (Uniprot/TrEMBL)
RAD51ProteinQ06609 (Uniprot/TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl Human)
RAFProteinP10398 (Uniprot/TrEMBL)
RALAProteinP11233 (Uniprot/TrEMBL)
RALGAPA1GeneProductENSG00000174373 (Ensembl Human)
RAP1AGeneProductENSG00000116473 (Ensembl Human)
RASGEF1AGeneProduct221002 (Entrez Gene)
RASGRP3GeneProductENSG00000152689 (Ensembl Human)
RHEBProteinQ15382 (Uniprot/TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
RHOGeneProductENSG00000163914 (Ensembl Human)
RPP38GeneProductENSG00000152464 (Ensembl Human)
RRASProteinP10301 (Uniprot/TrEMBL)
Raloxifene
SELKProteinQ9Y6D0 (Uniprot/TrEMBL)
SIRT1ProteinQ96EB6 (Uniprot/TrEMBL)
SMAD1ProteinQ15797 (Uniprot/TrEMBL)
SMAD2ProteinQ15796 (Uniprot/TrEMBL)
SMAD3ProteinQ13485 (Uniprot/TrEMBL)
SMAD4ProteinQ13485 (Uniprot/TrEMBL)
SMAD4ProteinQ15796 (Uniprot/TrEMBL)
SMAD6ProteinO43541 (Uniprot/TrEMBL)
SMAD7ProteinO15105 (Uniprot/TrEMBL)
SMCA4ProteinP51532 (Uniprot/TrEMBL)
SMEK1GeneProductENSG00000100796 (Ensembl Human)
SMEK2GeneProductENSG00000138041 (Ensembl Human)
SP1GeneProductENSG00000185591 (Ensembl Human)
STAT1ProteinP42224 (Uniprot/TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl Human)
TAB1ProteinQ15750 (Uniprot/TrEMBL)
TAK1LProteinP57077 (Uniprot/TrEMBL)
TFPIGeneProductENSG00000003436 (Ensembl Human)
TGFR1ProteinP36897 (Uniprot/TrEMBL)
TGFR2ProteinP37173 (Uniprot/TrEMBL)
TRADDProteinQ15628 (Uniprot/TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl Human)
TSC1ProteinQ92574 (Uniprot/TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl Human)
Tamoxifen
Tetradecanoylphorbol Acetate
Transcription
UBE2FProteinQ969M7 (Uniprot/TrEMBL)
UBIMProteinP35544 (Uniprot/TrEMBL)
UBP15ProteinQ9Y4E8 (Uniprot/TrEMBL)
UBP16ProteinQ9Y5T5 (Uniprot/TrEMBL)
UBP21ProteinQ9UK80 (Uniprot/TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl Human)
WEE1ProteinP30291 (Uniprot/TrEMBL)
XRCC3GeneProductENSG00000126215 (Ensembl Human)
ZMIZ1ProteinQ9ULJ6 (Uniprot/TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1984"
Personal tools