Integrated breast cancer pathway (Homo sapiens)

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101715142751910436188192011G2Cell CycleMBASC ComplexG1S3, 12, 13ProteasomeSMAD7ATMCASP3LetrozoleRAD50ZMIZ1TFPICDK2Penicillin GKRASATMCBPP85Q8NBS1DAG1MSH6BLMMSH2C9JNK1AnastrozoleNF1NCOA2STK11CYP19A1MPIP1ERKP13KBCL2RALALithium ChlorideBACH1NCOA3AKT1ERAL1PLK1BADALKB1RAD54LEGFRCTNB1 degradationRAD51CERK1HDAC1FLIP1CASP3IKKAAnti-ApoptosisCERK1P65C9JNK1CycloheximideAmpicillinSMAD4DexamethasoneMMP1BIDMTORATRBleomycinIPKAUBE2FCTNB1ODC1HydroxyureaTranscriptionCDH1ATF1C9JNK1NFKB1CHK2E2F1AngiogenesisBAKMRE11BRCA1P38BRAFBADWEE1NOXA1Cell Cycle arrestPAK1ProteinPKCB1RASGEF1AUBP21HDAC1/HDAC2TGFR1SELKNocodazoleMYCATRSMEK1RRASBMPR1ARaloxifeneESR1PRTamoxifenABL1JAK1SMAD3UBP16CERKDNASIRT1HIPK2CDK4AURKARPP38ARDHTANDRPHBMDM2TAK1LP53Cell survival and ProliferationABC3GSMCA4SMAD7SMAD4PLK3CAEstradiolP85ACorticosteroneRASGRP3GRNTGFR2Cell SurvivalProliferative genesAQP73SMAD6ERCCND1BARD1UBIMSMEK1CASP8RAFWEE1ApoptosisCREBRALGAPA1SMEK2FlutamideBAXSTAT1B5MEC1RAC1CDC42BARD1IKKARRASApoptosisE2F1XRCC3B3KP27MAXMethyl MethanesulfonateEP300PIAS1PlicamycinP53UBP21MDM2RHOP13BRCA2DonepezilCASP9AKT1RHEBGADD45ASMAD1HDAC1TSC2GSK3ACIP1AHRPTENTetradecanoylphorbol AcetatePLK3SMAD2VEGFACDK7ANXA1MAPKsJKIP1GRFOXO1BRCA1GCRTSC1UBP15Cancer DevelopmentPMLNAB1PPRB/RBRAP1ADCAKDTAB1CDK2ATRHydrocortisoneRHOBMPR2IMPA1JUNDihydrotestosteroneMPIP2GDIFADDCDC25ACell proliferationGene ExpressionIRS1MYT1RRASMitomycinCHK1CSNK1DFADDITPKCExemstaneTRADDTSC1SP116


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

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Quality Tags

Ontology Terms

 

Bibliography

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  3. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
126476view20:57, 5 May 2023EgonwAdded an identifier for the proteasome node
123531view06:33, 2 August 2022EgonwMade two pathways clickable
116548view12:47, 7 May 2021EweitzModified title
116285view21:46, 26 April 2021EweitzModified description
113594view09:46, 4 November 2020DeSlUpdated hydrocortisone ID (to drug ID).
110683view13:17, 28 May 2020EgonwAdded missing @Type annotation
108807view15:48, 30 January 2020DeSlReplaced P65 with MAP3K13
108804view15:38, 30 January 2020DeSlUpdated C9JNK1 to ZN655
108802view15:27, 30 January 2020DeSlRemoved B5MEC1; doesn't exist in original database anymore; no replacement; no lit.ref.
108799view15:00, 30 January 2020DeSlUpdated name FOSL2
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot/TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl Human)
AHRGeneProductENSG00000106546 (Ensembl Human)
AKT1ProteinP31749 (Uniprot/TrEMBL)
ALKB1ProteinQ13686 (Uniprot/TrEMBL)
ANDRProteinP10275 (Uniprot/TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl Human)
AQP73ProteinA6NL99 (Uniprot/TrEMBL)
ARProteinQ9UNE0 (Uniprot/TrEMBL)
ATF1ProteinP18846 (Uniprot/TrEMBL)
ATMProteinQ13315 (Uniprot/TrEMBL)
ATRProteinQ13535 (Uniprot/TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl Human)
Ampicillin
Anastrozole
Angiogenesis
Anti-Apoptosis
Apoptosis
B3KP27ProteinB3KP27 (Uniprot/TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot/TrEMBL)
BACH1ProteinO14867 (Uniprot/TrEMBL)
BADProteinQ92934 (Uniprot/TrEMBL)
BAKProteinQ16611 (Uniprot/TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl Human)
BAXGeneProductENSG00000087088 (Ensembl Human)
BCL2ProteinP10415 (Uniprot/TrEMBL)
BIDProteinP55957 (Uniprot/TrEMBL)
BLMProteinP54132 (Uniprot/TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl Human)
BMPR2ProteinQ13873 (Uniprot/TrEMBL)
BRAFProteinP15056 (Uniprot/TrEMBL)
BRCA1ProteinP38398 (Uniprot/TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl Human)
Bleomycin
C9JNK1ProteinC9JNK1 (Uniprot/TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CBPGeneProductENSG00000005810 (Ensembl Human)
CCND1ProteinP24385 (Uniprot/TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl Human)
CDH1GeneProductENSG00000039068 (Ensembl Human)
CDK2ProteinP24941 (Uniprot/TrEMBL)
CDK4ProteinP11802 (Uniprot/TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot/TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot/TrEMBL)
CHK2ProteinO96017 (Uniprot/TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot/TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl Human)
CSNK1DGeneProductENSG00000141551 (Ensembl Human)
CTNB1 degradation
CTNB1ProteinP35222 (Uniprot/TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl Human)
Cancer Development
Cell Cycle arrest
Cell Survival
Cell proliferation
Cell survival and Proliferation
Corticosterone
Cycloheximide
DAG1GeneProductENSG00000173402 (Ensembl Human)
DCAKDProteinQ8WVC6 (Uniprot/TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl Human)
DNA
Dexamethasone
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
Donepezil
E2F1GeneProduct1869 (Entrez Gene)
E2F1ProteinQ01094 (Uniprot/TrEMBL)
EGFRProteinP00533 (Uniprot/TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl Human)
ERAL1GeneProductENSG00000132591 (Ensembl Human)
ERKGeneProduct64781 (Entrez Gene)
ERProteinP16591 (Uniprot/TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl Human)
Estradiol
Exemstane
FADDGeneProductENSG00000168040 (Ensembl Human)
FADDProteinQ13158 (Uniprot/TrEMBL)
FLIP1ProteinQ7Z7B0 (Uniprot/TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl Human)
Flutamide
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GCRGeneProductENSG00000113161 (Ensembl Human)
GDIGeneProduct2664 (Entrez Gene)
GR ProteinP01833 (Uniprot/TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl Human)
GSK3AProteinP49840 (Uniprot/TrEMBL)
Gene Expression
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl Human)
HDAC1ProteinQ13547 (Uniprot/TrEMBL)
HDAC1Protein
HIPK2ProteinQ9H2X6 (Uniprot/TrEMBL)
Hydrocortisone
Hydroxyurea
IKKAProteinO15111 (Uniprot/TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl Human)
IPKAProteinP61925 (Uniprot/TrEMBL)
IRS1GeneProductENSG00000169047 (Ensembl Human)
ITPKCGeneProductENSG00000086544 (Ensembl Human)
JAK1ProteinP23458 (Uniprot/TrEMBL)
JKIP1ProteinQ96N16 (Uniprot/TrEMBL)
JUNGeneProductENSG00000177606 (Ensembl Human)
KRASGeneProductENSG00000133703 (Ensembl Human)
LetrozoleProtein
Lithium Chloride
MAPKsGeneProduct5594 (Entrez Gene)
MAXProteinP61244 (Uniprot/TrEMBL)
MDM2ProteinQ00987 (Uniprot/TrEMBL)
MMP1ProteinP03956 (Uniprot/TrEMBL)
MPIP1ProteinP30304 (Uniprot/TrEMBL)
MPIP2 ProteinP30305 (Uniprot/TrEMBL)
MRE11ProteinP49959 (Uniprot/TrEMBL)
MSH2ProteinP43246 (Uniprot/TrEMBL)
MSH6ProteinP52701 (Uniprot/TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl Human)
MYCProteinP01106 (Uniprot/TrEMBL)
MYT1ProteinQ01538 (Uniprot/TrEMBL)
Methyl Methanesulfonate
Mitomycin
NAB1ProteinQ13506 (Uniprot/TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl Human)
NCOA3GeneProductENSG00000124151 (Ensembl Human)
NF1ProteinP21359 (Uniprot/TrEMBL)
NFKB1 ProteinP19838 (Uniprot/TrEMBL)
NOXA1ProteinQ86UR1 (Uniprot/TrEMBL)
Nocodazole
ODC1Protein
P13KGeneProductENSG00000229882 (Ensembl Human)
P13ProteinQ9UHV8 (Uniprot/TrEMBL)
P38GeneProduct84640 (Entrez Gene)
P53ProteinP04637 (Uniprot/TrEMBL)
P65 ProteinC9JP65 (Uniprot/TrEMBL)
P85AGeneProductENSG00000125450 (Ensembl Human)
P85ProteinO00459 (Uniprot/TrEMBL)
PAK1ProteinQ13153 (Uniprot/TrEMBL)
PHBGeneProductENSG00000167085 (Ensembl Human)
PIAS1ProteinO75925 (Uniprot/TrEMBL)
PKCB1ProteinQ9ULU4 (Uniprot/TrEMBL)
PLK1ProteinP53350 (Uniprot/TrEMBL)
PLK3CAGeneProduct1263 (Entrez Gene)
PLK3GeneProductENSG00000173846 (Ensembl Human)
PMLProteinP29590 (Uniprot/TrEMBL)
PPRB/RBProteinP06400 (Uniprot/TrEMBL)
PRProteinP12270 (Uniprot/TrEMBL)
PTENProteinP60484 (Uniprot/TrEMBL)
Penicillin G
Plicamycin
Proliferative genes
Proteasome
ProteinProtein
Q8NBS1ProteinQ8NBS1 (Uniprot/TrEMBL)
RAC1ProteinP63000 (Uniprot/TrEMBL)
RAD50ProteinQ92878 (Uniprot/TrEMBL)
RAD51ProteinQ06609 (Uniprot/TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl Human)
RAFProteinP10398 (Uniprot/TrEMBL)
RALAProteinP11233 (Uniprot/TrEMBL)
RALGAPA1GeneProductENSG00000174373 (Ensembl Human)
RAP1AGeneProductENSG00000116473 (Ensembl Human)
RASGEF1AGeneProduct221002 (Entrez Gene)
RASGRP3GeneProductENSG00000152689 (Ensembl Human)
RHEBProteinQ15382 (Uniprot/TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
RHOGeneProductENSG00000163914 (Ensembl Human)
RPP38GeneProductENSG00000152464 (Ensembl Human)
RRASProteinP10301 (Uniprot/TrEMBL)
Raloxifene
SELKProteinQ9Y6D0 (Uniprot/TrEMBL)
SIRT1ProteinQ96EB6 (Uniprot/TrEMBL)
SMAD1ProteinQ15797 (Uniprot/TrEMBL)
SMAD2ProteinQ15796 (Uniprot/TrEMBL)
SMAD3ProteinQ13485 (Uniprot/TrEMBL)
SMAD4ProteinQ13485 (Uniprot/TrEMBL)
SMAD4ProteinQ15796 (Uniprot/TrEMBL)
SMAD6ProteinO43541 (Uniprot/TrEMBL)
SMAD7ProteinO15105 (Uniprot/TrEMBL)
SMCA4ProteinP51532 (Uniprot/TrEMBL)
SMEK1GeneProductENSG00000100796 (Ensembl Human)
SMEK2GeneProductENSG00000138041 (Ensembl Human)
SP1GeneProductENSG00000185591 (Ensembl Human)
STAT1ProteinP42224 (Uniprot/TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl Human)
TAB1ProteinQ15750 (Uniprot/TrEMBL)
TAK1LProteinP57077 (Uniprot/TrEMBL)
TFPIGeneProductENSG00000003436 (Ensembl Human)
TGFR1ProteinP36897 (Uniprot/TrEMBL)
TGFR2ProteinP37173 (Uniprot/TrEMBL)
TRADDProteinQ15628 (Uniprot/TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl Human)
TSC1ProteinQ92574 (Uniprot/TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl Human)
Tamoxifen
Tetradecanoylphorbol Acetate
Transcription
UBE2FProteinQ969M7 (Uniprot/TrEMBL)
UBIMProteinP35544 (Uniprot/TrEMBL)
UBP15ProteinQ9Y4E8 (Uniprot/TrEMBL)
UBP16ProteinQ9Y5T5 (Uniprot/TrEMBL)
UBP21ProteinQ9UK80 (Uniprot/TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl Human)
WEE1ProteinP30291 (Uniprot/TrEMBL)
XRCC3GeneProductENSG00000126215 (Ensembl Human)
ZMIZ1ProteinQ9ULJ6 (Uniprot/TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1984"
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