Wnt signaling (Homo sapiens)

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PIP2Wnt2+FrizzledDestruction complexCareleaseCSNK1DLRP5GSK3AROR1CSNK1EPRKCGTCF7L2GCKRTCF3MAP3K7DVL1CDK6RHOACTNNB1DVL1CTNNB1NFATC2TEKDVL2AXIN2PPARGCCND1ARRB2LRP6CCND1PI4K2AAXIN1AKT1PRKCBLEF1LRP6RAC1MAPK2FRAT1BCL9MYCCTBP1CSNK1A1TCF4APCGJA1PIP5K1BCSNK1G1DVL3PRKCASOX1MTORTSC1RYKPPGSK3BROR2MAPK9MAPK8PMAP3K7PTSC2NLKInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageWnt Signaling PathwayCYNUCYNUmRNAReceptorLigandProteinEnzyme complexProtein


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Wikipathways-description 
WNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, wg derived from the Drosophila gene wingless (wg) and int derived from the proto-oncogene integration-1, which is the mammalian homolog of wg. ß-catenin is the key regulated effector of Wnt, involved in canonical signaling . Free ß-catenin is bound by a multiprotein "destruction complex". The ß-catenin destruction complex is comprised of ß-catenin, scaffold proteins (APC, AXIN) and serine/threonine kinases that phosphorylate ß-catenin casein kinase 1 (CSNK1A1, CSNK1D, CSNK1E, CSNK1G1) and GSK3B. The sequential phosphorylation of ß-catenin by casein kinase 1 and GSK3 is recognised by an SCF-class E3-ubiquitin ligase, which targets it for polyubiquitination and proteosomal destruction. Canonical WNT signals are transduced through a two-part receptor, a seven-transmembrane Frizzled (FZD) and low density lipoprotein receptor-related protein 5/6 (LRP5/LRP6) to a ß-catenin (CTNNB1) signaling cascade. On recruitment of deshevelled (DVL1) to FZD and AXIN to LRP6, ß-catenin destruction complex disassembles leading to its stabilization and nuclear accumulation. Nuclear ß-catenin binds to T-cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors and Legless family docking protein, BCL9. These activate the transcription of Wnt target genes CCND1, MYC. Non-canonical WNT signaling diverges downstream after being transduced through FZD family receptors and co-receptors, ROR2 and RYK. This pathway does not involve ß-catenin-mediated gene expression. Small G proteins such as RAC1, RHOA and downstream effectors of RAC including JNK are DVL-dependant effector molecules of the non-canonical pathway. These have been implicated in cytoskeletal rearrangement, dendrite growth and control of cell polarity and orientation. Nemo-like kinase (NLK) and nuclear factor of activated T cells (NFAT) are Ca2+-dependant effectors of the non-canonical pathway. NLK inhibits canonical pathway by phosphorylation of TCF/LEF family transcription factors. NFAT transcription factor is implicated in convergent extension during early embryogenesis and carcinogenic metastasis.
 

NetPath_3 - Notch signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135215view04:00, 8 August 2024EweitzRestore state positions
135214view03:59, 8 August 2024EweitzRefine legend, economize layout
135213view03:55, 8 August 2024EweitzEconomize layout
129667view00:41, 22 May 2024EweitzModified title
126288view06:30, 20 April 2023EgonwLicense is CCZero
120695view12:55, 23 December 2021EweitzStandardize case
120668view01:15, 23 December 2021EweitzStandardize font, weight
117855view15:20, 22 May 2021EweitzModified title
116001view15:57, 28 March 2021EgonwCopied the NetPath paper to the literature list.
116000view15:56, 28 March 2021EgonwModified title
115982view18:10, 23 March 2021EgonwModified description
107433view06:44, 8 October 2019DeSlModified title
105470view05:17, 8 August 2019KhanspersModified description
97637view13:39, 31 May 2018Lorasimonsconnect line
97562view07:24, 25 May 2018Fehrhartadded citation
97561view07:22, 25 May 2018Fehrhartfixed lines
94887view18:04, 11 October 2017KhanspersModified title
78571view14:50, 7 January 2015MaintBotadded missing graphIds
70630view00:23, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
70108view19:00, 12 July 2013MaintBotupdated to 2013 schema
68007view06:28, 29 June 2013EgonwAdded missing "Entrez Gene" data sources to Proteins with an identifier (ID confirmed via Entrez Gene)
67750view11:58, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
62949view11:52, 5 May 2013MaintBotModified title
47977view14:34, 23 April 2012NetPathModified description
47854view17:27, 13 April 2012Sham.ukPeriodical save, work in progress
47851view17:17, 13 April 2012Sham.ukPeriodical save, work in progress
47850view17:07, 13 April 2012Sham.ukPeriodical save, work in progress
47849view16:57, 13 April 2012Sham.ukPeriodical save, work in progress
45009view17:40, 6 October 2011KhanspersOntology Term : 'Wnt signaling pathway' added !
44607view21:23, 21 September 2011KhanspersUpdating content to NetSlim
44606view21:22, 21 September 2011KhanspersUpdating content to NetSlim
44605view21:21, 21 September 2011KhanspersUpdating content to NetSlim
44121view20:51, 24 August 2011KhanspersReverted to version '23:40, 1 March 2011' by Khanspers
44016view22:39, 22 August 2011Khanspers
44010view22:11, 22 August 2011KhanspersModified description
44005view21:51, 22 August 2011KhanspersAdded category
44004view21:47, 22 August 2011KhanspersModified description
44003view21:40, 22 August 2011KhanspersModified description
44002view21:38, 22 August 2011Khanspersremoved GenMAPP comment
44001view21:37, 22 August 2011KhanspersModified description
44000view21:30, 22 August 2011KhanspersUpdating pathway from NetSlim
41151view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
38067view20:10, 6 August 2010AlexanderPicoadded wnt9b and connected to database
38019view02:40, 30 July 2010ElgavishReverted to version '02:33, 30 July 2010' by Elgavish
38018view02:39, 30 July 2010ElgavishSpecify description
38017view02:33, 30 July 2010ElgavishPCP pathway
38016view02:27, 30 July 2010ElgavishPeriodical save, work in progress
35029view09:17, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35021view09:11, 11 February 2010ThomasModified description
28127view19:35, 27 January 2009KhanspersReverted to version '13:36, 14 November 2008' by Khanspers

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1Protein207
APCProtein324
ARRB2Protein409
AXIN1Protein8312
AXIN2Rna8313 (Entrez Gene)
BCL9Protein607
CCND1Protein595
CCND1Rna595 (Entrez Gene)
CDK6Protein1021
CSNK1A1Protein1452
CSNK1DProtein1453
CSNK1EProtein1454
CSNK1G1Protein53944
CTBP1Protein1487
CTNNB1Protein1499
DVL1Protein1855
DVL2Protein1856
DVL3Protein1857
FRAT1Protein10023
GCKRProtein2646
GJA1Rna2697 (Entrez Gene)
GSK3AProtein2931
GSK3BProtein2932
LEF1Protein51176
LRP5Protein4041
LRP6Protein4040
MAP3K7Protein6885 (Entrez Gene)
MAPK2Protein2011 (Entrez Gene)
MAPK8Protein5599
MAPK9Protein5600
MTORProtein207 (Entrez Gene)
MYCRna4609 (Entrez Gene)
NFATC2Protein4773
NLKProtein51701
PI4K2AProtein55361 (Entrez Gene)
PIP5K1BProtein8395
PPARGProtein5468
PRKCAProtein5578
PRKCBProtein5579
PRKCGProtein5582
RAC1Protein5879
RHOAProtein387
ROR1Protein4919
ROR2Protein4920
RYKProtein6259
SOX1Protein6656
TCF3Protein6929
TCF4Protein6934
TCF7L2Protein6934
TEKRna7010 (Entrez Gene)
TSC1Protein7248 (Entrez Gene)
TSC2Protein7249

Annotated Interactions

No annotated interactions
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