Insulin signaling (Canis familiaris)

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1, 3MEK/MAP KinasesTranslation Regulationp70 S6 KinasesPDK/Akt SignalingCell GrowthDifferentiationTranscriptional Regulators & Immediate Early GenesVesicular TraffickingGlucose TransportInsulin Receptor SubstratesTor SignalingPI 3-Kinase isoformsModulators of Insulin ActionRas-MAPK Signalingp90 Rsk KinasesMetabolic RegulationPDPK1ARHGAP33SOCS3FOXO3PRKCBMAP4K3GYS1MAP2K3ELK1H-RASIGF1RKIF3AMAPK10PRKCDSOS1PIK3C2GRAC1CBLCIRS4EGR1GAB1EIF4EPFKLPRKCQMAPK6PRKCIMTORMAP4K2MAP3K7SNAP23SGKLGYG1LIPEFLOT1MAPK13MAPK1FOSAKT2STXBP4IRS3LOC100855651MAPK3TSC2CRKMAP3K3SHC3RPS6KA3LOC100855443PIK3R4RAB4AMAP2K4IRS1MAP3K1IRS1MAPK8RPS6KA1INPP4AINPPL1CYTH3PIK3CDSTXBP3LOC480487PRKCHSORBS1MAP3K8PTENAKT1CAP1EHD2MAPK9SRFXBP1MAP3K10MAPK8GRB2PRKCASGK2SLC2A1IKBKBRAF1RPS6KA5RPS6KB2EHD1PIK3C2ARRADSHC2INSRMAPK4GYS2PIK3CBMINK1PFKMLOC100856195MAP3K2TSC1MAP4K1STXBP1LOC100856150TRIB3RHOJMAP3K5EIF4EBP1MAPK7FOXO1ARF6PTPRFPIK3R1SOS2MAP4K5PRKAA2PTPN1SOCS1RPS6KA2MAP3K6PTPPTPN11PIK3C3MAPK11MAP2K1LOC100856339MAP2K6MAP3K13MAP3K14GRB14SNAP25RAC2CBLPPP1R3AMAPK12MAP3K4GSK3BRPS6KA4GSK3ARHOQMAP2K7PIK3MAP2K2CBLBRHEBPRKAA1SHC1MAP3K12RPS6KA6SLC2A4MAP3K9MAP4K4RAPGEF1PIK3CASTX4SGK1PIK3CGIRS2JUNMAPK14PIK3R2SH2B2MAP2K5VAMP2TBC1D4PRKCZGRB10MAP3K11RPS6KB1STXBP22


Description

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r45380) with a 95% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  3. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129527view01:16, 9 May 2024EweitzModified title
125471view13:29, 16 February 2023Mkutmonfix complexes
125470view13:28, 16 February 2023Mkutmonfix complexes and unconnected lines
125469view13:08, 16 February 2023EgonwRemoved the Last-Modified attribute
68506view21:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
48159view18:56, 9 May 2012MaintBotUpdating from human to fix xrefs
40657view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33949view18:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32535view13:01, 17 August 2009MaintBotFixed text labels
32222view12:46, 15 August 2009MaintBotFixed text labels
31718view11:54, 14 August 2009MaintBotFixed group labels
31233view19:45, 13 August 2009MaintBotFixed text labels
30654view22:34, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
ARF6GeneProduct490679 (Entrez Gene)
ARHGAP33GeneProduct484573 (Entrez Gene)
CAP1GeneProduct475317 (Entrez Gene)
CBLGeneProduct489369 (Entrez Gene)
CBLBGeneProduct487965 (Entrez Gene)
CBLCGeneProduct612343 (Entrez Gene)
CRKGeneProduct100684309 (Entrez Gene)
CYTH3GeneProduct609100 (Entrez Gene)
EGR1GeneProduct481528 (Entrez Gene)
EHD1GeneProduct100685675 (Entrez Gene)
EHD2GeneProduct484417 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
FLOT1GeneProduct474831 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FOXO3GeneProduct481954 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GRB10GeneProduct607755 (Entrez Gene)
GRB14GeneProduct478770 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3AGeneProduct484476 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
GYG1GeneProduct611614 (Entrez Gene)
GYS1GeneProduct611993 (Entrez Gene)
GYS2GeneProduct403737 (Entrez Gene)
H-RASGeneProduct403735 (Entrez Gene)
IGF1RGeneProduct442951 (Entrez Gene)
IKBKBGeneProduct482839 (Entrez Gene)
INPP4AGeneProduct474563 (Entrez Gene)
INPPL1GeneProduct485209 (Entrez Gene)
INSRGeneProduct484990 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
IRS3GeneProduct
IRS4GeneProduct492059 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
KIF3AGeneProduct474675 (Entrez Gene)
LIPEGeneProduct403607 (Entrez Gene)
LOC100855443GeneProduct100855443 (Entrez Gene)
LOC100855651GeneProduct100855651 (Entrez Gene)
LOC100856150GeneProduct100856150 (Entrez Gene)
LOC100856195GeneProduct100856195 (Entrez Gene)
LOC100856339GeneProduct100856339 (Entrez Gene)
LOC480487GeneProduct480487 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP2K3GeneProduct489547 (Entrez Gene)
MAP2K4GeneProduct
MAP2K5GeneProduct609559 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
MAP2K7GeneProduct485004 (Entrez Gene)
MAP3K10GeneProduct484504 (Entrez Gene)
MAP3K11GeneProduct483732 (Entrez Gene)
MAP3K12GeneProduct607170 (Entrez Gene)
MAP3K13GeneProduct100685499 (Entrez Gene)
MAP3K14GeneProduct490926 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K2GeneProduct612902 (Entrez Gene)
MAP3K3GeneProduct480481 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAP3K5GeneProduct476215 (Entrez Gene)
MAP3K6GeneProduct487345 (Entrez Gene)
MAP3K7GeneProduct
MAP3K8GeneProduct487085 (Entrez Gene)
MAP3K9GeneProduct490765 (Entrez Gene)
MAP4K1GeneProduct484527 (Entrez Gene)
MAP4K2GeneProduct483759 (Entrez Gene)
MAP4K3GeneProduct475734 (Entrez Gene)
MAP4K4GeneProduct481331 (Entrez Gene)
MAP4K5GeneProduct490685 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MAPK11GeneProduct607019 (Entrez Gene)
MAPK12GeneProduct607023 (Entrez Gene)
MAPK13GeneProduct612821 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct479790 (Entrez Gene)
MAPK4GeneProduct491690 (Entrez Gene)
MAPK6GeneProduct478311 (Entrez Gene)
MAPK7GeneProduct489532 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MINK1GeneProduct100686834 (Entrez Gene)
MTORGeneProduct478232 (Entrez Gene)
PDPK1GeneProduct479875 (Entrez Gene)
PFKLGeneProduct487797 (Entrez Gene)
PFKMGeneProduct403849 (Entrez Gene)
PIK3GeneProduct
PIK3C2AGeneProduct485399 (Entrez Gene)
PIK3C2GGeneProduct477681 (Entrez Gene)
PIK3C3GeneProduct490477 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PIK3R4GeneProduct477064 (Entrez Gene)
PPP1R3AGeneProduct482411 (Entrez Gene)
PRKAA1GeneProduct479351 (Entrez Gene)
PRKAA2GeneProduct489571 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PTENGeneProduct403832 (Entrez Gene)
PTPGeneProduct
PTPN11GeneProduct477488 (Entrez Gene)
PTPN1GeneProduct477263 (Entrez Gene)
PTPRFGeneProduct475389 (Entrez Gene)
RAB4AGeneProduct479210 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAC2GeneProduct481271 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RAPGEF1GeneProduct491286 (Entrez Gene)
RHEBGeneProduct475545 (Entrez Gene)
RHOJGeneProduct612985 (Entrez Gene)
RHOQGeneProduct474579 (Entrez Gene)
RPS6KA1GeneProduct487353 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KA3GeneProduct491768 (Entrez Gene)
RPS6KA4GeneProduct612105 (Entrez Gene)
RPS6KA5GeneProduct490831 (Entrez Gene)
RPS6KA6GeneProduct491989 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
RPS6KB2GeneProduct610499 (Entrez Gene)
RRADGeneProduct611304 (Entrez Gene)
SGK1GeneProduct403647 (Entrez Gene)
SGK2GeneProduct610835 (Entrez Gene)
SGKLGeneProduct
SH2B2GeneProduct489820 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SHC2GeneProduct611955 (Entrez Gene)
SHC3GeneProduct
SLC2A1GeneProduct482437 (Entrez Gene)
SLC2A4GeneProduct403673 (Entrez Gene)
SNAP23GeneProduct478268 (Entrez Gene)
SNAP25GeneProduct477158 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SORBS1GeneProduct100686806 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
SRFGeneProduct612861 (Entrez Gene)
STX4GeneProduct489919 (Entrez Gene)
STXBP1GeneProduct609241 (Entrez Gene)
STXBP2GeneProduct403880 (Entrez Gene)
STXBP3GeneProduct490128 (Entrez Gene)
STXBP4GeneProduct491094 (Entrez Gene)
TBC1D4GeneProduct485494 (Entrez Gene)
TRIB3GeneProduct485819 (Entrez Gene)
TSC1GeneProduct480688 (Entrez Gene)
TSC2GeneProduct479883 (Entrez Gene)
VAMP2GeneProduct479491 (Entrez Gene)
XBP1GeneProduct477532 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1085"
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