Spinal cord injury (Homo sapiens)

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367PLXNA2NOCSPG4TNFSF13BCD47LTBPTPRZ1LTB4TNFSF13PDYNNGFRLTB4R143392920Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZFP36FCGR2APRB1PTPRAIL1BZFP36NOS2TNFNR4A1IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5CXCL1Neutrophil Chemoattractants21, 22IL8NeurtrophilsMonocytesAQP440TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating4Activated Microglia/Macrophages(Transient)RepairIL1BNOS2TNFARG1TOXIC FERROUSIRONFocal AdensionsEPHA48, 28TTEPHNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)24CCNG1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP9TT5Chondroitin Sulfate Proteoglycans2NCANSLIT1Axon Retraction2SLIT2SLIT3NTN1RGMATTTTTTTTTTMMP95MMP9MMP95TT5TTTTCCR2IL1R122TTECM BreakdownECM BreakdownIL1ACXCL1Monocyte Chemoattractants21, 22CXCL2CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA1TT15TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors32ICAM1SELPTTTTPlasticityKLK827TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAPTT5IntermediateFillament23CDK4TACR1E2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCASP3TP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition23IgG, IgMTP53TT39TTTTGRIN1VIM2642TTT Cell Stimulating4FK50635PPP3CATTFK506FK5063030GAP43TTFK506Axonal Regeneration30FKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB331MyelinInjury ResponseArachidonic acidPGH2PTGS237TT18ROSNOX4MIR23BOlomoucine17CDK1GDNF1TTSEMA6ATT29Axonal GrowthInhibitionGJA1ATP-Release6TTBDNFTTImmediate Response Genes24


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

View all...
  1. David S, Kroner A; ''Repertoire of microglial and macrophage responses after spinal cord injury.''; Nat Rev Neurosci, 2011 PubMed Europe PMC Scholia
  2. Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S; ''Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages.''; Biomed Res, 2005 PubMed Europe PMC Scholia
  3. Eng LF, Ghirnikar RS, Lee YL; ''Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).''; Neurochem Res, 2000 PubMed Europe PMC Scholia
  4. Lأ³pez-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S; ''Phospholipase A2 superfamily members play divergent roles after spinal cord injury.''; FASEB J, 2011 PubMed Europe PMC Scholia
  5. ''''; , PubMed Europe PMC Scholia
  6. Yu CG, Yezierski RP, Joshi A, Raza K, Li Y, Geddes JW; ''''; , PubMed Europe PMC Scholia
  7. DAGCI T, ARMAGAN G, KONYALIOGLU S, YALCIN A; ''Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells.''; Physiol Res, 2009 PubMed Europe PMC Scholia
  8. Tian DS, Dong Q, Pan DJ, He Y, Yu ZY, Xie MJ, Wang W; ''''; , PubMed Europe PMC Scholia
  9. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, Shields CB, Xu XM; ''Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury.''; J Neuropathol Exp Neurol, 2007 PubMed Europe PMC Scholia
  10. Zhang S, Huan W, Wei H, Shi J, Fan J, Zhao J, Shen A, Teng H; ''FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat.''; J Cell Biochem, 2013 PubMed Europe PMC Scholia
  11. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, Ohsaki H, Takeda E, Nishisho T; ''A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.''; J Neurochem, 2001 PubMed Europe PMC Scholia
  12. Shim SO, Cafferty WB, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM; ''PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition.''; Mol Cell Neurosci, 2012 PubMed Europe PMC Scholia
  13. Saganovأ، K, Gأ،lik J, Blaإ،ko J, Korimovأ، A, Raؤچekovأ، E, Vanickأ½ I; ''''; , PubMed Europe PMC Scholia
  14. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S; ''''; , PubMed Europe PMC Scholia
  15. Erschbamer M, Pernold K, Olson L; ''Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.''; J Neurosci, 2007 PubMed Europe PMC Scholia
  16. Dekaban GA, Thawer S; ''Pathogenic antibodies are active participants in spinal cord injury.''; J Clin Invest, 2009 PubMed Europe PMC Scholia
  17. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B; ''''; , PubMed Europe PMC Scholia
  18. Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR; ''Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice.''; Brain Res, 2012 PubMed Europe PMC Scholia
  19. Menet V, Prieto M, Privat A, Gimأ©nez y Ribotta M; ''''; , PubMed Europe PMC Scholia
  20. Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muiأ  C, Esposito E, Bramanti P, Cuzzocrea S; ''TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome.''; Shock, 2008 PubMed Europe PMC Scholia
  21. Ju P, Zhang S, Yeap Y, Feng Z; ''Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury.''; Glia, 2012 PubMed Europe PMC Scholia
  22. McKillop WM, Dragan M, Schedl A, Brown A; ''''; , PubMed Europe PMC Scholia
  23. Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I; ''''; , PubMed Europe PMC Scholia
  24. Wang YF, Fan ZK, Cao Y, Yu DS, Zhang YQ, Wang YS; ''2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury.''; Brain Res, 2011 PubMed Europe PMC Scholia
  25. Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK; ''''; , PubMed Europe PMC Scholia
  26. Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, Yokomizo T, Iwamoto Y, Okada S; ''The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.''; Am J Pathol, 2010 PubMed Europe PMC Scholia
  27. Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, Hagg T, Whittemore SR; ''CD47 knockout mice exhibit improved recovery from spinal cord injury.''; Neurobiol Dis, 2011 PubMed Europe PMC Scholia
  28. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI; ''''; , PubMed Europe PMC Scholia
  29. Puschmann TB, Turnley AM; ''''; , PubMed Europe PMC Scholia
  30. Pajoohesh-Ganji A, Knoblach SM, Faden AI, Byrnes KR; ''Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice.''; Brain Res, 2012 PubMed Europe PMC Scholia
  31. Tohda C, Kuboyama T; ''Current and future therapeutic strategies for functional repair of spinal cord injury.''; Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  32. Sharma HS; ''''; , PubMed Europe PMC Scholia
  33. Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S; ''Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.''; Neuroscience, 2007 PubMed Europe PMC Scholia
  34. Schwab JM, Frei E, Klusman I, Schnell L, Schwab ME, Schluesener HJ; ''AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats.''; J Neuroimmunol, 2001 PubMed Europe PMC Scholia
  35. ''''; , PubMed Europe PMC Scholia
  36. Chu GK, Yu W, Fehlings MG; ''The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury.''; Neuroscience, 2007 PubMed Europe PMC Scholia
  37. Cafferty WB, Duffy P, Huebner E, Strittmatter SM; ''''; , PubMed Europe PMC Scholia
  38. Wu J, Stoica BA, Faden AI; ''Cell cycle activation and spinal cord injury.''; Neurotherapeutics, 2011 PubMed Europe PMC Scholia
  39. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Grأ¤slund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T; ''Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.''; J Proteome Res, 2006 PubMed Europe PMC Scholia
  40. Sharma HS; ''''; , PubMed Europe PMC Scholia
  41. Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T; ''Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.''; J Neurosci, 2012 PubMed Europe PMC Scholia
  42. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC; ''''; , PubMed Europe PMC Scholia
  43. Resnick DK, Graham SH, Dixon CE, Marion DW; ''Role of cyclooxygenase 2 in acute spinal cord injury.''; J Neurotrauma, 1998 PubMed Europe PMC Scholia
  44. Kitayama M, Ueno M, Itakura T, Yamashita T; ''Activated microglia inhibit axonal growth through RGMa.''; PLoS One, 2011 PubMed Europe PMC Scholia
  45. Fernأ،ndez-Martos CM, Gonzأ،lez P, Rodriguez FJ; ''Acute leptin treatment enhances functional recovery after spinal cord injury.''; PLoS One, 2012 PubMed Europe PMC Scholia
  46. Pineau I, Sun L, Bastien D, Lacroix S; ''Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion.''; Brain Behav Immun, 2010 PubMed Europe PMC Scholia
  47. Lavezzi AM, Casale V, Oneda R, Weese-Mayer DE, Matturri L; ''Sudden Infant Death Syndrome and Sudden Intrauterine Unexplained Death: Correlation Between Hypoplasia of Reaphé Nuclei and Serotonin Transporter Gene Promoter Polymorphism.''; Pediatr Res, 2009 PubMed Europe PMC Scholia
  48. ''''; , PubMed Europe PMC Scholia
  49. Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, Knapp PE; ''Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons.''; Neuroscience, 2007 PubMed Europe PMC Scholia
  50. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ; ''Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury.''; J Neurotrauma, 2011 PubMed Europe PMC Scholia
  51. Farooque M, Isaksson J, Olsson Y; ''Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice.''; Neuroreport, 1999 PubMed Europe PMC Scholia
  52. Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV; ''Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury.''; PLoS One, 2011 PubMed Europe PMC Scholia
  53. Chalimoniuk M, King-Pospisil K, Metz CN, Toborek M; ''Macrophage migration inhibitory factor induces cell death and decreases neuronal nitric oxide expression in spinal cord neurons.''; Neuroscience, 2006 PubMed Europe PMC Scholia
  54. Fabes J, Anderson P, Yأ،أ±ez-Muأ±oz RJ, Thrasher A, Brennan C, Bolsover S; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135135view21:23, 6 August 2024EweitzOntology Term : 'neutrophil' added !
135134view21:21, 6 August 2024EweitzOntology Term : 'oligodendrocyte' added !
135133view21:21, 6 August 2024EweitzOntology Term : 'macrophage' added !
130893view00:28, 31 May 2024EweitzOntology Term : 'spinal cord motor neuron' added !
130892view00:27, 31 May 2024EweitzOntology Term : 'motor neuron' added !
130891view00:25, 31 May 2024EweitzOntology Term : 'B cell' added !
130890view00:25, 31 May 2024EweitzOntology Term : 'T cell' added !
130889view00:25, 31 May 2024EweitzOntology Term : 'microglial cell' added !
130888view00:24, 31 May 2024EweitzOntology Term : 'monocyte' added !
120812view15:03, 11 January 2022SusanOntology Term : 'neurological disorder pathway' added !
117177view09:56, 18 May 2021EweitzModified title
106712view13:15, 17 September 2019MaintBotHMDB identifier normalization
105820view23:01, 15 August 2019KhanspersModified description
104858view14:59, 20 June 2019DeSlRemoved weird signs in lit. ref (part 1)
104853view14:52, 20 June 2019DeSlUpdated empty lit. ref
104850view14:46, 20 June 2019DeSlCOnnected unconnected lines.
104843view14:33, 20 June 2019DeSlChanged lines for motor neuron to graphical lines.
101932view12:38, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
87678view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84650view22:21, 10 March 2016Khanspersupdated mmp12 xref
80343view18:15, 9 June 2015Khanspersupdated color and type for MIR23B
79963view13:55, 28 April 2015Zaricorected annotation PTGS2 from chimpanzee to human, annotated Ros
79931view12:14, 27 April 2015EveloRenamed IL8 with the new official HGNC name CXCL8
78556view10:31, 7 January 2015MaintBotadded missing graphIds
76332view08:13, 2 July 2014MkutmonFixed annotation for C5
74098view22:56, 29 March 2014Ariuttaupdate arrowhead
69988view22:03, 11 July 2013MaintBotupdating to 2013 schema
59143view00:06, 22 February 2013DMicaelSpecify description
59080view21:55, 21 February 2013MaintBotUpdated Ensembl data source
58412view22:54, 12 February 2013NsalomonisSpecify description
58411view22:50, 12 February 2013DMicaelSpecify description
58410view22:46, 12 February 2013NsalomonisSpecify description
58380view21:35, 12 February 2013DMicaelPeriodical save, work in progress
58378view21:15, 12 February 2013DMicaelPeriodical save, work in progress
58373view20:23, 12 February 2013DMicaelSpecify description
58370view19:52, 12 February 2013DMicaelPeriodical save, work in progress
58349view16:11, 12 February 2013NsalomonisSpecify description
58322view04:15, 12 February 2013NsalomonisSpecify description
58321view04:14, 12 February 2013NsalomonisSpecify description
58317view23:46, 11 February 2013DMicaelPeriodical save, work in progress
58315view23:15, 11 February 2013DMicaelPeriodical save, work in progress
58313view23:05, 11 February 2013DMicaelPeriodical save, work in progress
58309view22:33, 11 February 2013DMicaelPeriodical save, work in progress
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58304view21:42, 11 February 2013DMicaelSpecify description
58303view21:40, 11 February 2013DMicaelSpecify description
58302view21:39, 11 February 2013DMicaelSpecify description
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58296view20:42, 11 February 2013DMicaelPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACANGeneProductENSG00000157766 (Ensembl Human)
ANXA1GeneProductENSG00000135046 (Ensembl Human)
AQP4GeneProductENSG00000171885 (Ensembl Human)
ARG1GeneProductENSG00000118520 (Ensembl Human)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
BCANGeneProductENSG00000132692 (Ensembl Human)
BDNFGeneProductENSG00000176697 (Ensembl Human)
BTG2GeneProductENSG00000159388 (Ensembl Human)
C5GeneProductENSG00000106804 (CTD Gene)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CCL2GeneProductENSG00000108691 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCNG1GeneProductENSG00000113328 (Ensembl Human)
CCR2GeneProductENSG00000121807 (Ensembl Human)
CD47GeneProductENSG00000196776 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CHST11GeneProductENSG00000171310 (Ensembl Human)
COL2A1GeneProductENSG00000139219 (Ensembl Human)
COL4A1GeneProductENSG00000187498 (Ensembl Human)
CSPG4GeneProductENSG00000173546 (Ensembl Human)
CXCL10GeneProductENSG00000169245 (Ensembl Human)
CXCL1GeneProductENSG00000163739 (Ensembl Human)
CXCL2GeneProductENSG00000081041 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
E2F5GeneProductENSG00000133740 (Ensembl Human)
EGR1GeneProductENSG00000120738 (Ensembl Human)
EPHA4GeneProductENSG00000116106 (Ensembl Human)
EPHNB2GeneProductENSG00000125266 (Ensembl Human)
FBRGeneProduct
FCGR2AGeneProductENSG00000143226 (Ensembl Human)
FK506Metabolite104987-11-3 (CAS)
FKBP1AGeneProductENSG00000088832 (Ensembl Human)
FOSGeneProductENSG00000170345 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GAP43GeneProductENSG00000172020 (Ensembl Human)
GDNFGeneProductENSG00000168621 (Ensembl Human)
GFAPGeneProductENSG00000131095 (Ensembl Human)
GJA1GeneProductENSG00000152661 (Ensembl Human)
GRIN1GeneProductENSG00000176884 (Ensembl Human)
ICAM1GeneProductENSG00000090339 (Ensembl Human)
IFNGGeneProductENSG00000111537 (Ensembl Human)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProductENSG00000125538 (Ensembl Human)
IL1R1GeneProductENSG00000115594 (Ensembl Human)
IL2GeneProductENSG00000109471 (Ensembl Human)
IL4GeneProductENSG00000113520 (Ensembl Human)
IL6GeneProductENSG00000136244 (Ensembl Human)
IL8GeneProductENSG00000169429 (Ensembl Human)
KLK8GeneProductENSG00000129455 (Ensembl Human)
LILRB3GeneProductENSG00000204577 (Ensembl Human)
LTB4Metabolite169 (PubChem)
LTB4RGeneProductENSG00000213903 (Ensembl Human)
LTBGeneProductENSG00000227507 (Ensembl Human)
MAGGeneProductENSG00000105695 (Ensembl Human)
MAPK1GeneProductENSG00000100030 (Ensembl Human)
MAPK3GeneProductENSG00000102882 (Ensembl Human)
MBPGeneProductENSG00000197971 (Ensembl Human)
MIR23BGeneProductENSG00000207563 (Ensembl Human)
MMP12GeneProductENSG00000110347 (Ensembl Human)
MMP9GeneProductENSG00000100985 (Ensembl Human)
MYCGeneProductENSG00000136997 (Ensembl Human)
NCANGeneProductENSG00000130287 (Ensembl Human)
NGFRGeneProductENSG00000064300 (Ensembl Human)
NOMetabolite145068 (PubChem)
NOS1GeneProductENSG00000089250 (Ensembl Human)
NOS2GeneProductENSG00000007171 (Ensembl Human)
NOX4GeneProductENSG00000086991 (Ensembl Human)
NR4A1GeneProductENSG00000123358 (Ensembl Human)
NTN1GeneProductENSG00000065320 (Ensembl Human)
OMGGeneProductENSG00000126861 (Ensembl Human)
OlomoucineMetaboliteHMDB35233 (HMDB)
PDYNGeneProductENSG00000101327 (Ensembl Human)
PGH2MetaboliteHMDB01381 (HMDB)
PLA2G2AGeneProductENSG00000188257 (Ensembl Human)
PLA2G5GeneProductENSG00000127472 (Ensembl Human)
PLA2G6GeneProductENSG00000184381 (Ensembl Human)
PLXNA2GeneProductENSG00000076356 (Ensembl Human)
PPP3CAGeneProductENSG00000138814 (Ensembl Human)
PRB1GeneProductENSG00000251655 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PTGS2GeneProduct469616 (Entrez Gene)
PTPRAGeneProductENSG00000132670 (Ensembl Human)
PTPRZ1GeneProductENSG00000106278 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RGMAGeneProductENSG00000182175 (Ensembl Human)
RHOAGeneProductENSG00000067560 (Ensembl Human)
RHOBGeneProductENSG00000143878 (Ensembl Human)
RHOCGeneProductENSG00000155366 (Ensembl Human)
ROCK2GeneProductENSG00000134318 (Ensembl Human)
ROSGeneProduct
RTN4GeneProductENSG00000115310 (Ensembl Human)
RTN4RGeneProductENSG00000040608 (Ensembl Human)
SELPGeneProductENSG00000174175 (Ensembl Human)
SEMA6AGeneProductENSG00000092421 (Ensembl Human)
SLIT1GeneProductENSG00000187122 (Ensembl Human)
SLIT2GeneProductENSG00000145147 (Ensembl Human)
SLIT3GeneProductENSG00000184347 (Ensembl Human)
SOX9GeneProductENSG00000125398 (Ensembl Human)
TACR1GeneProductENSG00000115353 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TLR4GeneProductENSG00000136869 (Ensembl Human)
TNFGeneProductENSG00000232810 (Ensembl Human)
TNFSF13BGeneProductENSG00000102524 (Ensembl Human)
TNFSF13GeneProductENSG00000161955 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
VCANGeneProductENSG00000038427 (Ensembl Human)
VIMGeneProductENSG00000026025 (Ensembl Human)
XYLT1GeneProductENSG00000103489 (Ensembl Human)
ZFP36GeneProductENSG00000128016 (Ensembl Human)
melittinMetabolite16133648 (PubChem)

Annotated Interactions

No annotated interactions

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