Estrogen signaling pathway (Bos taurus)

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RNA Pol IITFIIFInhibitionMitochondrionTATA Box bindingproteinActivationEREanti apoptosis+pTFIIHTranslocationTFIIDTIFsTFIIAHistone Deacetylases (HDACs)+pMAPKsNucleusTFIIEHDACsGene expressionTranscription Initiation Factors (TIFs)TFIIB+pRNA polymerase IIIKKsGene expression(anti apoptotic)TAF6EstradiolMAPK9POLR2AAKT1POLR2JSOS1HDAC5BCL2MNAT1GTF2H1GTF2E1HDAC1NCOR1CDK7BRAFMAPK14HDAC6TBPGTF2F2POLR2ECCND1NEMO_BOVINGRB2HDAC8GTF2H3POLR2Cp300Q0VD16_BOVINSIN3AFOSEstradiolGTF2A2POLR2GEstradiolLOC517559GTF2BTAF9ELK1Cyclic AMPBCL2POLR2ISRCPOLR2BCREB1TBPCREBBPRASPOLR2KGPERNFKB1GTF2H4ESR1TAF13LOC509843EstradiolHDAC3TAF5ESR1CCNHGTF2E2ESR1PRKACAERCC3EstradiolESR1SP1ESR1EstradiolIPI00906958.1GNGT1IKKB_BOVINERCC2GTF2H2ESR1ILKTAF7NFKB1JUNGTF2A2HDAC2EstradiolESR1GNB1GNASTAF12EstradiolBRCA1ESR1IKKA_BOVINPOLR2HCREB1SHC2PIK3CAPOLR2FESR1Estradiol


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 95% conversion rate.

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Bibliography

  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
105997view11:52, 16 August 2019MaintBotHMDB identifier normalization
80825view15:27, 30 June 2015Mkutmonhomology conversion
72369view09:49, 13 November 2013EgonwFixed a typo.
72368view09:48, 13 November 2013EgonwFixed the PubChem-compound database name.
70170view00:31, 13 July 2013AlexanderPicoModified title
63371view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
58820view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40543view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33784view00:10, 9 December 2009MaintBotAutomatic update of empty xrefs
33629view10:04, 1 December 2009MaintBotRemoved group label
31640view22:26, 13 August 2009MaintBotFixed text labels
30555view22:01, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
BCL2GeneProduct281020 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
BRCA1GeneProduct353120 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CCNHGeneProduct615512 (Entrez Gene)
CDK7GeneProduct515462 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
Cyclic AMPMetabolite6076 (PubChem)
ELK1GeneProduct786886 (Entrez Gene)
ERCC2GeneProduct100125238 (Entrez Gene)
ERCC3GeneProduct507984 (Entrez Gene)
ESR1GeneProduct407238 (Entrez Gene)
EstradiolMetabolite5757 (PubChem)
FOSGeneProduct280795 (Entrez Gene)
GNASGeneProduct281793 (Entrez Gene)
GNB1GeneProduct281201 (Entrez Gene)
GNGT1GeneProduct281796 (Entrez Gene)
GPERGeneProduct527831 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GTF2A2GeneProduct613479 (Entrez Gene)
GTF2BGeneProduct513231 (Entrez Gene)
GTF2E1GeneProduct540525 (Entrez Gene)
GTF2E2GeneProduct510921 (Entrez Gene)
GTF2F2GeneProduct509259 (Entrez Gene)
GTF2H1GeneProduct513510 (Entrez Gene)
GTF2H2GeneProduct511829 (Entrez Gene)
GTF2H3GeneProduct511896 (Entrez Gene)
GTF2H4GeneProduct100137723 (Entrez Gene)
HDAC1GeneProduct404126 (Entrez Gene) HDAC1; histone deacetylase 1
HDAC2GeneProduct407223 (Entrez Gene) HDAC2; histone deacetylase 2
HDAC3GeneProduct404125 (Entrez Gene) HDAC3; histone deacetylase 3
HDAC5GeneProduct504242 (Entrez Gene) HDAC5; histone deacetylase 5
HDAC6GeneProduct513602 (Entrez Gene) HDAC6; histone deacetylase 6
HDAC8GeneProduct540666 (Entrez Gene) HDAC8; histone deacetylase
IKKA_BOVINGeneProductENSBTAG00000007591 (Ensembl)
IKKB_BOVINGeneProductENSBTAG00000007599 (Ensembl)
ILKGeneProduct540207 (Entrez Gene)
IPI00906958.1GeneProductENSBTAG00000010312 (Ensembl)
JUNGeneProduct280831 (Entrez Gene)
LOC509843GeneProduct509843 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC517559GeneProduct517559 (Entrez Gene) HDAC4; histone deacetylase 4
MAPK14GeneProduct534492 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MNAT1GeneProduct534176 (Entrez Gene)
NCOR1GeneProduct507663 (Entrez Gene)
NEMO_BOVINGeneProductENSBTAG00000006268 (Ensembl)
NFKB1GeneProduct616115 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
POLR2AGeneProduct282312 (Entrez Gene)
POLR2BGeneProduct538184 (Entrez Gene)
POLR2CGeneProduct504452 (Entrez Gene)
POLR2EGeneProduct512971 (Entrez Gene)
POLR2FGeneProduct534232 (Entrez Gene)
POLR2GGeneProduct526320 (Entrez Gene)
POLR2HGeneProduct505599 (Entrez Gene)
POLR2IGeneProduct614472 (Entrez Gene)
POLR2JGeneProduct540428 (Entrez Gene)
POLR2KGeneProduct614776 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
Q0VD16_BOVINGeneProductENSBTAG00000033983 (Ensembl)
RASGeneProduct
SHC2GeneProduct533455 (Entrez Gene)
SIN3AGeneProduct518504 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SP1GeneProduct540741 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
TAF12GeneProduct614227 (Entrez Gene)
TAF13GeneProduct513065 (Entrez Gene)
TAF5GeneProduct516001 (Entrez Gene)
TAF6GeneProduct505638 (Entrez Gene)
TAF7GeneProduct509327 (Entrez Gene)
TAF9GeneProduct532936 (Entrez Gene)
TBPGeneProduct516578 (Entrez Gene)
p300GeneProduct

Annotated Interactions

No annotated interactions
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