Apoptosis modulation by HSP70 (Bos taurus)

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ApoptosomeMitochondriaCELL SURVIVALAPOPTOSISTNF-alphaProteasomeDegradation ofIk alpha(activation of NFkB)STRESSInhibitionInhibitionNF-kBpathwayActivationInhibitionInhibitionDegradation of proteinsFAS-LigandCASP7CASP3CASP6FADDBIDFASCYCSMAPK10MAP3K1CASP2AIFM1CASP9CASP8TNFRSF1AFADDCASP8APAF1RIPK1HSPA1AHSPA1ANFKB1HSPA1ACYCS


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Comments

GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print] 
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78. 
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
Right click for info. Adapted from rat by GenMAPP
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 69% conversion rate.

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Bibliography

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  1. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia
  2. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  4. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
  6. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  7. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
  8. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122662view05:35, 28 April 2022EgonwMade a pathway clickable
117073view14:30, 16 May 2021EweitzModified title
98546view20:52, 14 September 2018KhanspersModified description
98539view20:49, 14 September 2018Khanspersremoved GenMAPP comments
98538view20:49, 14 September 2018KhanspersModified description
98537view20:49, 14 September 2018KhanspersModified description
80857view15:28, 30 June 2015Mkutmonhomology conversion
72060view17:22, 24 October 2013Mkutmonupdated annotation for APAF1
72024view12:47, 24 October 2013Mkutmonfixed unconnected lines
67052view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
63306view20:54, 9 May 2013MaintBotUpdated to 2013 gpml schema
62054view08:38, 24 April 2013Andra
40607view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33844view00:33, 9 December 2009MaintBotAutomatic update of empty xrefs
32532view13:00, 17 August 2009MaintBotFixed text labels
32219view12:45, 15 August 2009MaintBotFixed text labels
31715view11:53, 14 August 2009MaintBotFixed group labels
31230view19:44, 13 August 2009MaintBotFixed text labels
30651view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AIFM1GeneProduct535714 (Entrez Gene) Apoptosis Inducing Factor
APAF1GeneProduct
BIDGeneProduct782484 (Entrez Gene)
CASP2GeneProduct531419 (Entrez Gene)
CASP3GeneProduct408016 (Entrez Gene)
CASP6GeneProduct538409 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CYCSGeneProduct510767 (Entrez Gene)
FADDGeneProduct493720 (Entrez Gene)
FASGeneProduct282488 (Entrez Gene)
HSPA1AGeneProduct282254 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
RIPK1GeneProduct504727 (Entrez Gene)
TNFRSF1AGeneProduct282527 (Entrez Gene)

Annotated Interactions

No annotated interactions
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