Butyrate-induced histone acetylation (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Davie JR; ''Inhibition of histone deacetylase activity by butyrate.''; J Nutr, 2003 PubMed Europe PMC Scholia
2. Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ; ''The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation.''; Mol Cell, 2012 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	123102	view	08:57, 3 July 2022	Egonw	Made two pathways clickable
	105116	view	13:51, 8 July 2019	DeSl	Changed ID for HDACs from Wikidata to InterPro
	102201	view	14:53, 9 December 2018	Egonw	Replaced Wikipedia with Wikidata identifiers.
	89148	view	21:58, 22 August 2016	Ariutta	Ontology Term : 'classic metabolic pathway' added !
	88590	view	19:35, 11 August 2016	Mkutmon	fix unconnected lines
	73980	view	11:32, 13 March 2014	MaintBot	Clarified what inhibits the HDACs.
	73979	view	11:30, 13 March 2014	MaintBot
	73978	view	11:23, 13 March 2014	MaintBot	Converted 'beta oxidaton' to a label.
	73977	view	11:14, 13 March 2014	MaintBot
	73976	view	11:09, 13 March 2014	MaintBot	More identifiers.
	73975	view	11:02, 13 March 2014	MaintBot	More identifiers and fixed AKT and ACL to be protein.
	73974	view	10:58, 13 March 2014	MaintBot	Used ChEBI instead of InChIs (for now)
	73973	view	10:47, 13 March 2014	MaintBot	Modified description
	69937	view	20:01, 11 July 2013	Mkutmon	fixed unconnected lines
	69009	view	17:46, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	57918	view	20:38, 4 February 2013	MaintBot	Modified categories
	54005	view	10:13, 18 November 2012	Egonw	Completed the diagram
	54004	view	09:59, 18 November 2012	Egonw	Ensured all translocations are now MIM conversions (as suggested on the ML).
	53994	view	19:16, 17 November 2012	Egonw
	53993	view	18:03, 17 November 2012	Egonw	Added InChIs.
	53933	view	13:23, 16 November 2012	Egonw	Added reference and several interactions
	53932	view	13:15, 16 November 2012	Egonw	Added the core metabolites
	53931	view	13:01, 16 November 2012	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ACL	Metabolite
AKT	Metabolite
Acetyl CoA	Metabolite	InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1 (InChI)
Acetylated Histone	Complex
Beta oxidation
Butyrate	Metabolite	InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 (InChI)
Citrate	Metabolite	InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 (InChI)
Glucose	Metabolite	InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 (InChI)
HDACs
Lipid biosynthesis
TCA cycle	Pathway

Annotated Interactions

No annotated interactions