Integrin-mediated cell adhesion (Mus musculus)

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1PI3KRAFcell motilitycell maintenanceF-actinPAKMEKPhosphatidylinositiolF-actinITGAcell maintenanceECMIntegrin alphacell proliferationp130 CasCAPNPAKC3GERKCAPNITGBIntegrin betasignaling systemMapk1Itga2bCskItga6Rock2SrcItga11Capn7Ptk2Akt2Pak2MYO-PRaf1Itgb3Capn10Vav3Rac3Capn5Rac2Tns1Hras1Itga9PI5KArafRhoItgaeItga7Itga1Pak4Akt1Pik3r2Cdc42ItgamAkt3BrafSos1Map2k1Arhgef7Mapk10Tln1Pak6Cav1Capn2Itgb6Pdpk1Map2k6Dock1Capn9Itga10Git2Mapk6ItgalVav2Capn3Capn11Rap1aItga3ZyxItgaxShc3Actn1Capn1Capns1Sorbs1ItgadSepp1Map2k3Pak1Itgb4IlkFynMyoGrb2Rap1bMapk4CrkItga2Itga4Rapgef1Mylk2Itga8Shc1Pak3Cav3PxnItga5Mapk12ItgavItgb5Cav2Ptk2VclMapk7VaspItgb7Map2k2Bcar1Capn6Itgb8Rac1Rock1Itgb2Map2k5p110SrcItgb1


Description

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 94% conversion rate.

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Ontology Terms

 

Bibliography

  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116713view09:53, 11 May 2021EweitzModified title
97547view14:43, 24 May 2018DeSlChanged wrong database (GenBank to Entrez Gene).
90168view14:16, 20 October 2016Mkutmonfix unconnected lines
72138view09:40, 25 October 2013Mkutmonadded datasource for Cdc42
71730view20:17, 17 October 2013MaintBotAutomated update of data sources
71319view17:16, 17 October 2013MaintBotAutomated update of data sources
70036view02:01, 12 July 2013AlexanderPicoModified title
69105view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67402view10:56, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62831view04:45, 3 May 2013MaintBotUpdated UniProt data source
41290view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35605view15:48, 12 February 2010ThomasModified description
35598view15:44, 12 February 2010Thomasadded literature
32725view22:42, 3 September 2009MaintBotAdded xrefs
32724view22:35, 3 September 2009MaintBotading xrefs
32164view14:05, 14 August 2009MaintBotFixed group labels
30900view00:24, 30 July 2009MaintBotConverted from Homo sapiens
20685view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:WP6]]: Moved to stable identifier
8220view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:Mus musculus:Integrin-mediated cell adhesion KEGG]]: Renaming species
7730view16:13, 18 December 2007MaintBotfixed category names
7269view12:41, 4 November 2007MaintBotAdded categories to GPML
6469view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Integrin-mediated_cell_adhesion_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Actn1GeneProduct109711 (GenBank)
Akt1GeneProduct11651 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
Akt2GeneProduct11652 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
Akt3GeneProduct23797 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ArafGeneProduct11836 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Arhgef7GeneProduct54126 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
Bcar1GeneProduct12927 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BrafGeneProduct109880 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
Capn10GeneProduct23830 (Entrez Gene) CAPN10; calpain 10 [EC:3.4.22.17
Capn1GeneProduct12333 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
Capn11GeneProduct268958 (Entrez Gene) CAPN11; calpain 11 [EC:3.4.22.17]
Capn2GeneProduct12334 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
Capn3GeneProduct12335 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:3.4.22.17]
Capn5GeneProduct12337 (Entrez Gene) CAPN5; calpain
Capn6GeneProduct12338 (Entrez Gene) CAPN6; calpain 6 [EC:3.4.22.17]
Capn7GeneProduct12339 (Entrez Gene) CAPN7; calpain 7 [EC:3.4.22.17
Capn9GeneProduct73647 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
Capns1GeneProduct12336 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
Cav1GeneProduct12389 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
Cav2GeneProduct12390 (Entrez Gene) CAV2; caveolin 2
Cav3GeneProduct12391 (Entrez Gene) CAV3; caveolin 3
Cdc42GeneProduct12540CDC42; cell division cycle 42 (GTP binding protein 25kD)
CrkGeneProduct12928 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CskGeneProduct12988 (Entrez Gene) CSK; c-src tyrosine kinase [EC:2.7.1.112]
Dock1GeneProduct330662 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FynGeneProduct14360 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Git2GeneProduct26431 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
Grb2GeneProduct14784 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
Hras1GeneProduct15461 (Entrez Gene)
IlkGeneProduct16202 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
Itga10GeneProduct213119 (Entrez Gene)
Itga1GeneProduct109700 (Entrez Gene)
Itga11GeneProduct319480 (Entrez Gene)
Itga2GeneProduct16398 (Entrez Gene)
Itga2bGeneProduct16399 (Entrez Gene)
Itga3GeneProduct16400 (Entrez Gene)
Itga4GeneProduct16401 (Entrez Gene)
Itga5GeneProduct16402 (Entrez Gene)
Itga6GeneProduct16403 (Entrez Gene)
Itga7GeneProduct16404 (Entrez Gene)
Itga8GeneProduct241226 (Entrez Gene)
Itga9GeneProduct104099 (Entrez Gene)
ItgadGeneProduct381924 (Entrez Gene)
ItgaeGeneProduct16407 (Entrez Gene)
ItgalGeneProduct16408 (Entrez Gene)
ItgamGeneProduct16409 (Entrez Gene)
ItgavGeneProduct16410 (Entrez Gene)
ItgaxGeneProduct16411 (Entrez Gene)
Itgb1GeneProduct16412 (Entrez Gene)
Itgb2GeneProduct16414 (Entrez Gene)
Itgb3GeneProduct16416 (Entrez Gene)
Itgb4GeneProduct192897 (Entrez Gene)
Itgb5GeneProduct16419 (Entrez Gene)
Itgb6GeneProduct16420 (Entrez Gene)
Itgb7GeneProduct16421 (Entrez Gene)
Itgb8GeneProduct320910 (Entrez Gene)
MYO-PGeneProduct
Map2k1GeneProduct26395 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Map2k2GeneProduct26396 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3GeneProduct26397 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Map2k5GeneProduct23938 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Map2k6GeneProduct26399 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Mapk10GeneProduct26414 (Entrez Gene)
Mapk12GeneProduct29857 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Mapk1GeneProduct26413 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Mapk4GeneProduct225724 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk6GeneProduct50772 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Mapk7GeneProduct23939 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Mylk2GeneProduct228785 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
MyoGeneProduct17928 (Uniprot/TrEMBL)
PI5KGeneProduct
Pak1GeneProduct18479 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
Pak2GeneProduct224105 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
Pak3GeneProduct18481 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
Pak4GeneProduct70584 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
Pak6GeneProduct214230 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
Pdpk1GeneProduct18607 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
Pik3r2GeneProduct18709 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
Ptk2GeneProduct14083 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PxnGeneProduct19303 (Entrez Gene) PXN; paxillin
Rac1GeneProduct19353 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
Rac2GeneProduct19354 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
Rac3GeneProduct170758 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
Raf1GeneProduct110157 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Rap1aGeneProduct109905 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
Rap1bGeneProduct215449 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
Rapgef1GeneProduct107746 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RhoGeneProduct212541 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
Rock1GeneProduct19877 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
Rock2GeneProduct19878 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
Sepp1GeneProduct20363 (Entrez Gene) SEPP1; selenoprotein P plasma
Shc1GeneProduct20416 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Shc3GeneProduct20418 (Entrez Gene) SHC3; neuronal Sh
Sorbs1GeneProduct20411 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
Sos1GeneProduct20662 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SrcGeneProduct20779 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
Tln1GeneProduct21894 (Entrez Gene) TLN1; talin 1
Tns1GeneProduct21961 (Entrez Gene) TNS; tensi
VaspGeneProduct22323 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
Vav2GeneProduct22325 (Entrez Gene) VAV2; vav 2 oncogene
Vav3GeneProduct57257 (Entrez Gene) VAV3; vav 3 oncogene
VclGeneProduct22330 (Entrez Gene) VCL; vinculin
ZyxGeneProduct22793 (Entrez Gene) ZYX; zyxin
p110GeneProduct

Annotated Interactions

No annotated interactions
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