PDGF pathway (Homo sapiens)

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PRASA1(GAP)NFkBPDGFRBPDGFBMP2K1(MEK 1)SHC1PLCG1H-Ras-1(Ras)MAP3K1(MEKK1)STAT1AP-1(c-Jun)SH-PTP2(PTN11)SOS1MAP2K4(JNKK1)MAPK8(JNK1)PDGFARAF1STAT3GRB2PDGFANFkB1-10STAT1STAT3STAT3STAT1PPPPSTAT3STAT1PPPJAK1PPCyclic AMP(cAMP)DAGProstaglandin I2(PGI2)IP3COX2PIP2[4',5']Ca2+Phospholipid(containing arachidonic acid)PLA2G4A(cPLA2)Cell proliferationCachannel[Ca2+]iArachidonic acidERK1/2(MAPK3/MAPK1)ELK1c-FosSRFNa+/H+exchangerH+NaPI3KPc-SrcPTIAM1Vav2Rac1RhoAPor1(ARF1P2)PAK1Vav1CDC42N-WASPFilopodiaFormationActin,Stress Fibersand AdhesionLamellipodiaFormationcell migration involved in sprouting angiogenesisIKKAktPathwayIkB alphaPDegradation


Description

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st

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Bibliography

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  1. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC Scholia
  2. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC Scholia
  3. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC Scholia
  4. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC Scholia
  5. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC Scholia
  6. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  7. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC Scholia
  8. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC Scholia
  9. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  10. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123068view04:20, 23 June 2022EgonwMade a pathway clickable
121697view03:35, 26 February 2022EweitzUse official gene symbol
117815view14:48, 22 May 2021EweitzModified title
107132view14:21, 17 September 2019MaintBotChEBI identifier normalization
106717view13:15, 17 September 2019MaintBotHMDB identifier normalization
106552view00:13, 6 September 2019KhanspersModified description
105476view05:22, 8 August 2019KhanspersModified description
103637view23:03, 22 March 2019AlexanderPicofixed xref datasource
101933view12:40, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
96312view09:02, 8 March 2018Mkutmonremove outdated pathway attributes
96257view16:14, 2 March 2018EgonwOntology Term : 'platelet-derived growth factor signaling pathway' added !
95977view15:52, 11 February 2018EgonwThese interactions are not mim-conversions.
82681view13:07, 22 October 2015EgonwReplace CAS numbers of CaCl2 with ChEBI identifiers for the actual metabolites.
80006view12:18, 30 April 2015Zariannotated and updated Id for ERK1/2 (MAPK3/MAPK1), H-Ras-1 (Ras) , MAP2K4 (JNKK1)
78551view10:30, 7 January 2015MaintBotadded missing graphIds
76331view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
72247view21:52, 29 October 2013Khanspersremoved GeneOntology xrefs from data nodes
72152view11:00, 25 October 2013EgonwAdded a ChEBI ID for 'phospholipid'.
72031view13:04, 24 October 2013Mkutmonfixed unconnected lines
71715view20:08, 17 October 2013MaintBotUpdated data sources
70400view23:27, 28 July 2013AmanzoWork in progress
70399view23:24, 28 July 2013AmanzoWork in progress
70398view23:17, 28 July 2013AmanzoPeriodical save, work in progress
70397view22:47, 28 July 2013AmanzoPeriodical save, work in progress
70396view22:37, 28 July 2013AmanzoPeriodical save, work in progress
70395view22:27, 28 July 2013AmanzoPeriodical save, work in progress
70394view22:17, 28 July 2013AmanzoPeriodical save, work in progress
70393view22:07, 28 July 2013AmanzoPeriodical save, work in progress
70294view17:24, 16 July 2013AmanzoReferences added
70293view17:18, 16 July 2013AmanzoPeriodical save, work in progress
70292view17:05, 16 July 2013AmanzoOntology Term : 'cancer' added !
70291view17:05, 16 July 2013AmanzoOntology Term : 'Jak-Stat signaling pathway' added !
70290view17:02, 16 July 2013AmanzoModified description
70289view16:47, 16 July 2013AmanzoWork in progress
70288view16:36, 16 July 2013AmanzoPeriodical save, work in progress
70287view16:26, 16 July 2013AmanzoPeriodical save, work in progress
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70285view15:55, 16 July 2013AmanzoPeriodical save, work in progress
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70281view14:53, 16 July 2013AmanzoPeriodical save, work in progress
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70278view14:03, 16 July 2013AmanzoPeriodical save, work in progress
70276view22:15, 15 July 2013AmanzoPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment

Ca

c h a n n e

l		ProteinGO:0034704 (GeneOntology)

Na+/H+

e x c h a n g e

r		ProteinGO:0034704 (GeneOntology)
AP-1 (c-Jun)GeneProductP05412 (Uniprot/TrEMBL)
Actin,

Stress Fibers

and Adhesion		PathwayGO:0042127 (GeneOntology)
Akt PathwayPathwayGO:0042127 (GeneOntology)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
CDC42ProteinP60953 (Uniprot/TrEMBL)
COX2ProteinP00403 (Uniprot/TrEMBL)
Ca2+Metabolite10043-52-4 (CAS)
Cell proliferationPathwayGO:0042127 (GeneOntology)
Cyclic AMP (cAMP)MetaboliteHMDB00058 (HMDB)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DegradationPathwayGO:0042127 (GeneOntology)
ELK1GeneProductP19419 (Uniprot/TrEMBL)
ERK1/2 (MAPK3/MAPK1)GeneProductP27361 /P28482 (Uniprot/TrEMBL)
Filopodia FormationPathwayGO:0042127 (GeneOntology)
GRB2ProteinP62993 (Uniprot/TrEMBL)
H+Metabolite10043-52-4 (CAS)
H-Ras-1 (Ras)GeneProduct
IKKProteinO15111 (Uniprot/TrEMBL)
IP3Metabolite16595 (ChEBI)
IkB alphaGeneProductP25963 (Uniprot/TrEMBL)
JAK1ProteinP23458 (Uniprot/TrEMBL)
Lamellipodia FormationPathwayGO:0042127 (GeneOntology)
MAP2K4 (JNKK1)GeneProduct
MAP3K1 (MEKK1)GeneProductQ13233 (Uniprot/TrEMBL)
MAPK8 (JNK1)GeneProductP45983 (Uniprot/TrEMBL)
MP2K1 (MEK 1)GeneProductQ02750 (Uniprot/TrEMBL)
N-WASPProteinO00401 (Uniprot/TrEMBL)
NFkBGeneProduct4790 (KEGG Genes)
NaMetabolite10043-52-4 (CAS)
P

D G F

A		GeneProduct5154 (Entrez Gene)
PAK1ProteinQ13153 (Uniprot/TrEMBL)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PI3KProteinP27986 (Uniprot/TrEMBL)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4A (cPLA2)GeneProductENSG00000116711 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
Phospholipid (containing arachidonic acid)Metabolite
Por1 (ARF1P2)ProteinP53365 (Uniprot/TrEMBL)
Prostaglandin I2 (PGI2)MetaboliteHMDB01335 (HMDB)
RAF1ProteinP04049 (Uniprot/TrEMBL)
RASA1(GAP)GeneProductENSG00000145715 (Ensembl Human)
Rac1ProteinP63000 (Uniprot/TrEMBL)
RhoAProteinP61586 (Uniprot/TrEMBL)
SH-PTP2 (PTN11)GeneProductQ06124 (Uniprot/TrEMBL)
SHC1ProteinP29353 (Uniprot/TrEMBL)
SOS1ProteinQ07889 (Uniprot/TrEMBL)
SRFGeneProductP11831 (Uniprot/TrEMBL)
STAT1ProteinP42224 (Uniprot/TrEMBL)
STAT3ProteinP40763 (Uniprot/TrEMBL)
TIAM1ProteinQ13009 (Uniprot/TrEMBL)
Vav1ProteinP15498 (Uniprot/TrEMBL)
Vav2ProteinP52735 (Uniprot/TrEMBL)
[Ca2+]iMetabolite10043-52-4 (CAS)
c-FosGeneProductP01100 (Uniprot/TrEMBL)
c-SrcProteinP12931 (Uniprot/TrEMBL)
cell migration involved in sprouting angiogenesisPathwayGO:0002042 (GeneOntology)

Annotated Interactions

No annotated interactions

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