DNA replication (Danio rerio)

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1, 2dGTPwith the replication forkMcm2RNA PrimerMcm4RNA primer-DNA primerOrc ComplexUbiquitinPhosphorylation of Mcm 2-7 complexADPMcm3Orc2Mcm5RNA primer-DNA primer:origin duplex:PCNAHOMOLOGY MAPPMcm5Orc2Orc3RNA primer-DNA primerOrc complexProcessive complexRFC40Cdc6Mcm6Cdt15. Leading/lagging strand synthesisATP2. Activation of the pre-replicative complexDNA Polymerasep180DNA polymerase alpha: primase: origin complexPre-replicative complexCdc6RFC Heteropentamer:RNA primer-DNA primer:Orc2Orc4dUTPMcm6dATPDNA polymerase alpha: primase: origin complexUbiquitinated Cdc6Cdt1Ubiquitinated Orc1Cdt1Degraded by proteasome in cytosolRFC140ADPOrc3ATPOrc complexp581. Assembly of the pre-replicative complexGTPPhosphorylated Orc1Orc complex3. DNA replication initiationCdt1Orc3Cdt1Pre-replicative complexaRFC36Cdc6Mcm7Mcm 4,6,7 trimer forms and associatesMcm2RFC384. Switching of origins to post-replicative stateCdc6UTPOriginOrc5Orc complexRFC Heteropentamer:RNA primer-DNA primerATPPhosphorylated Cdc6Mcm3Orc4Mcm4PCNA homotrimerCTPGemininp49Orc1p70ATPUbiquitindCTPOrc3RFC37Mcm7Orc5Mcm10PrimaseDegraded by proteasome in cytosolOrc5Orc2POLD4zgc:85772rfc5zgc:110727POLD1rfc4mcm2zgc:110810mcm3zgc:101602orc1lPOLD3zgc:56264prim1MCM6ASKmcm5zgc:77841UBCzgc:56310MCM7rpa2ORC2Lpcnaorc3lgmnnRFC1orc6lpold2POLE2POLAzgc:77827UBA52POLECDC6zgc:56598mcm4rpa1RPA4CDT1rfc3MCM10


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC6GeneProduct
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2LGeneProduct
POLAGeneProduct
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProduct
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProduct
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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