Mitotic G2-G2/M phases (Homo sapiens)

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16529115, 21351718, 282123613, 17, 27214114249, 26, 3132231769308, 10, 33, 3423123, 2518, 20, 283, 253519227Cyclin Aphospho-Cdk2Cyclin B Golgi membraneE2F1/E2F3 centrosome-nucleated microtubules Nlp-depleted centrosome Mature centrosomes enriched in gamma-TURC complexes Phosphorylated Myosin Phosphatase gamma-tubulin complex Cyclin BCdc2 complex phospho-E2F1/E2F3 gamma-tubulin complex Cyclin Aphospho-Cdc2p-T161-CDK1CCNB1 Cyclin B1phospho-Cdc2 Cyclin Aphospho-Cdk2Cyclin B2phospho-Cdc2Cyclin B1phospho-Cdc2gamma-TuSC gamma-TuSC Cyclin Aphospho-Cdc2nuclear Cyclin B1phospho-Cdc2 centrosome-associated NuMA gamma-tubulin complex RAB8AGTP phospho-cyclin B1centrosome nuclear Cyclin B1Cdc2 complexes Cyclin B1phospho-Cdc2centrosome gamma-TuSC NuMA homodimer Phospho-Cyclin B1 Cyclin Aphospho-Cdc2Cyclin Aphospho-Cdk2gamma-tubulin complex phospho-Cdc2centrosome gamma-TuSC centrosome containing phosphorylated Nlp RAB8AGTP Cyclin Aphospho-Cdc2Cyclin Aphospho-Cdk2centrosome nuclear Cyclin B1phospho-Cdc2 Cyclin Aphospho-Cdk2phospho-Cyclin B1gamma-tubulin complex cytosolOPTNRAB8AGTP gamma-TuSC Cyclin B2phospho-Cdc2nucleoplasmCentrosomes containing recruited CDK11p58 cNAP-1 depleted centrosome centrosome-nucleated microtubules Cyclin Bphospho-Cdc2NuMA-bound microtubules Cyclin B phospho-cyclin B1Cyclin A2phospho-Cdc2Cyclin B1phospho-Cdc2 cytoplasmic Cyclin B1Cdc2 complexes Cyclin B1phospho-Cdc2NuMA homodimer Cyclin A1phospho-Cdc2phospho-Cyclin B1phospho-Cdc2Centrosome associated Plk1 Cyclin ACdc2 CAK Cyclin B1phospho-Cdc2centrosome-nucleated microtubules Cyclin B1phospho-Cdc2NuMA homodimer ADPHAUS2 PLK4 CEP192 PPP2R1ACEP135 SSNA1 HSP90AA1 CCP110 DYNC1H1 CSNK1E H2OPLK1 CEP250 AKAP9 OFD1 CEP192 RAB8AGTPp-T210-PLK1PAFAH1B1NEDD1 ODF2 CCNB2 ATPAKAP9 CSNK1D SDCCAG8 PLK1 CEP76 RAB8A DCTN3ALMS1 TUBGCP4 PLK4 Pip-T161-CDK1 CEP290 CLASP1 ATPPLK1 Cyclin B2phospho-Cdc2ACTR1A centrosome containing phosphorylated NlpCEP76 Phosphorylated Myosin PhosphataseTUBG2 TUBB gamma-tubulin complexTUBGCP3 TUBA1A MAPRE1 HAUS2 E2F1/E2F3PPP2R1ACEP63 TUBG1 CEP164 ADPPCM1 TUBA4A CEP57 CEP290 CEP57 CSNK1D SDCCAG8 TUBB4B ATPDYNLL1 YWHAE SSNA1 ADPCENPJ TUBA1A E2F1 TUBGCP6 ADPPPP2R1ACEP63 CNTRL NuMA-bound microtubulesYWHAE OFD1 CCP110 MAPRE1 CCNB1 p-T14-CDK1 NDE1 DYNLL1 nuclear Cyclin B1Cdc2 substratesDCTN3PRKAR2B CEP192 TUBGCP4 Cyclin Aphospho-Cdk2ADPCyclin Aphospho-Cdk2CEP164 CEP250 CEP152 DCTN3G2/M transition proteinsPRKACA PLK4 YWHAGp-T14,T161-CDK1 CDC25CCDK5RAP2 AZI1 ALMS1 SDCCAG8 CEP78 CCNB1 ATPSFI1 DYNC1H1 ATPTUBGCP3 CSNK1E E2F3 phospho-Cyclin B1TUBB4A CEP63 DYNLL1 p-S177-OPTNDCTN1-2 p-T14,Y15,T161-CDK1 ADPODF2 p-T210-PLK1FGFR1OPPRKACA TUBG1 CSNK1E CNTRL DYNC1H1 phospho-G2/M transition proteinPRKAR2B CSNK1E DYNLL1 CEP78 CEP192 DYNC1H1 Cyclin Aphospho-Cdc2PKMYT1CLASP1 TUBA4A TUBB4A CNTRL HSP90AA1 TUBGCP3 HAUS2 CRS kinaseAZI1 ODF2 CDK5RAP2 CEP57 NDE1 PCNT CEP76 CENPJ CDK1 Cyclin Bphospho-Cdc2SFI1 PAFAH1B1CCNB1 ADPFGFR1OPODF2 p-T14-CDK1 PRKAR2B CEP290 NEDD1 NEK2 SSNA1 centrosomep-T160-CDK2 CDK5RAP2 CEP57 CDK1 Cdc25CEP41 ALMS1 SSNA1 PAFAH1B1PAFAH1B1DCTN1-2 ODF2 ATPCyclin A1phospho-Cdc2NINL PPP1R12B-4 ADPTUBA1A NINL CEP41 OFD1 TUBGCP6 HSP90AA1 AZI1 CCP110 TUBG2 TUBGCP3 PPP2R1ATUBGCP5 PRKACA MNAT1 DCTN1-2 AKAP9 PPP2R1AOFD1 DCTN2 NEDD1 CETN2 NEDD1 p-T161-CDK1 Cyclin Aphospho-Cdc2SFI1 CCNB2 HAUS2 p-T161-CDK1 Cyclin B1phospho-Cdc2CEP70 ADPTUBGCP6 ATPCEP290 Cyclin A1Cdk2 phosphorylated G2/M transition proteinPLK1ALMS1 p-T161-CDK1 TUBG1 TUBB TUBGCP5 p-T161-CDK1 CEP41 CEP57 CEP250 CETN2 TUBA1A HAUS2 p-T160-CDK2 HAUS2 ATPTUBB OPTNRAB8AGTPH2OMature centrosomes enriched in gamma-TURC complexesFGFR1OPp-NUMA1 AKAP9 PLK4 DCTN1-2 DYNC1I2 PRKACA Centrosomes containing recruited CDK11p58CEP70 TUBB4B CCNA2 TUBGCP5 DCTN1-2 CCNA1 PiSFI1 CETN2 NDE1 PLK4 p-T14,Y15,T161-CDK1 SSNA1 CCP110 PCNT DCTN2 RAB8A AZI1 DYNLL1 p-T161-CDK1 CEP78 PPP2R1Ap-NINL PCNT TUBA4A CDK5RAP2 DYNC1H1 PCNT ODF2 CCNB1 Cyclin B1phospho-Cdc2 CCNB1 CSNK1D ALMS1 GTP phospho-cyclin B1ADPCCNB2 p-T161-CDK1 CAKCEP135 TUBB4B AKAP9 Cyclin A2Cdk2 phosphorylated G2/M transition proteinphospho-Cdc2HSP90AA1 CEP152 SDCCAG8 Cyclin Aphospho-Cdc2CDK7 CDK1 CEP152 CSNK1E CEP57 CEP41 TUBGCP2 CEP63 PCNT CEP192 CEP135 CEP76 ODF2 YWHAGCDK1MAPRE1 DYNC1H1 YWHAGnuclear Cyclin B1phospho-Cdc2 Cyclin A2phospho-Cdc2p-T14-CDK1 PRKAR2B p-4S-CCNB1 TUBGCP4 TUBGCP5 TUBB4B NEDD1 DYNC1I2 TUBB4B TUBGCP5 SDCCAG8 p-T161-CDK1CCNB1ATPCKAP5 CDC25BDCTN2 CEP135 PCM1 PRKAR2B nuclear Cyclin B1Cdc2 complexesG2/M transition proteinAKAP9 TUBG1 TUBB4A CDK5RAP2 p-T14-CDK1 NEDD1 ACTR1A CEP70 p-T14,T161-CDK1 ADPYWHAE Cyclin BCdc2 complexPRKACA TUBB Centrosome associated Plk1p-4S-CCNB1 NINL CEP290 XPO1DCTN3YWHAGFGFR1OPCEP290 PLK1 TUBG1 TUBGCP2 DCTN1-2 Cyclin BCEP164 ATPMAPRE1 NDE1 PLK1 CEP63 TUBG2 centrosome-nucleated microtubulesactive nuclear Cyclin B1Cdc2 complexesCdc25DCTN3PCM1 NINL TUBB CNTRL p-T14-CDK1 p-S53-WEE1CEP192 CLASP1 CEP250SFI1 CEP152 DYNC1I2 TUBB Phospho-Cyclin B1 NEK2 CEP135 ADPNEDD1 CEP41 CEP76 CEP72 TUBGCP2 H2OCyclin Aphospho-Cdc2CEP152 NEDD1 CEP192 DYNC1H1 MAPRE1 CKAP5 Pip-T161-CDK1 CEP135 TUBG1 CCP110 CEP164 DYNC1I2 WEE1NEDD1 CNTRL SDCCAG8 NDE1 p-4S-CCNB1 YWHAE p-PKMYT1p-T14,Y15,T161-CDK1 Cyclin B2phospho-Cdc2CKAP5 NEK2 ACTR1A CDK1 CLASP1 PiNEK2 p-4S-CCNB1 CEP78 FGFR1OPCyclin ATUBA4A CDK11p58TUBB4A CSNK1D OPTN Nlp-depleted centrosomeCENPJ NEDD1 CEP72 CENPJ p-T14,T161-CDK1 TUBB ALMS1 CEP250 YWHAE Cyclin B1phospho-Cdc2CETN2 DYNC1I2 CEP63 CCNB1 CEP164 TUBGCP6 p-NUMA1 PRKACA CSNK1E PPP1CB YWHAE p-S198-CDC25Cp-NUMA1H2OSSNA1 DCTN3SSNA1 CCNB1 PCNT TUBA1A p-NUMA1 TUBA4A CEP164 TUBB4B TUBB4A OFD1 CSNK1D ADPCDK5RAP2 cNAP-1 depleted centrosomeTUBG1 PLK1 YWHAGACTR1A TUBA1A ATPTUBG1 Cyclin ACdc2ALMS1 SDCCAG8 CEP72 CEP76 MAPRE1 CCP110 NEK2 CEP152 CLASP1 CEP72 DCTN2 CCNB2 phospho-G2/M transition proteinTUBA1A CENPJ CCNH DCTN3PLK1CETN2 CDK1 PRKAR2B H2OCDK1 NDE1 CDK5RAP2 CEP78 PLK1DCTN2 CEP250 p-T161-CDK1 YWHAGTUBG1 CEP72 ATPCEP78 AZI1 DYNC1I2 NuMA homodimerNEDD1 CEP70 SFI1 TUBG1 CSNK1D ADPNEK2 TUBGCP2 p-4S-CCNB1 CKAP5 MAPRE1 SFI1 PLK4 CCNB1 CEP290 CETN2 DYNLL1 CENPJ CEP78 CEP70 PCM1 CEP72 PAFAH1B1PRKACA TUBGCP4 PLK4 PCNT p-E2F1 TUBGCP6 CEP72 CDK1 PAFAH1B1HSP90AA1 p-S473-PPP1R12A HSP90AA1 GTP CEP250 CEP63 DYNLL1 p-T161-CDK1 p-T161-CDK1 CKAP5 CEP76 p-E2F3 ATPPCM1 CCNB1 CKAP5 ATPp-T14,Y15,T161-CDK1 CCNB1 CETN2 CSNK1E HAUS2 PRKAR2B CNTRL PCM1 NDE1 CENPJ phosphorylated nuclear Cyclin B1Cdc2 substratesTUBG2 p-T14-CDK1 CKAP5 Cyclin B1phospho-Cdc2YWHAGDCTN1-2 TUBA4A CDC25CCDK1 AZI1 TUBB4A Cyclin Aphospho-Cdk2CEP152 CLASP1 TUBG2 YWHAE CEP70 ATPCLASP1 PPP2R1ACNTRL CEP135 PLK1 TUBGCP2 ACTR1A ACTR1A FGFR1OPHSP90AA1 TUBGCP4 NEK2 CEP41 Cdc25DCTN2 TUBA4A FGFR1OPG2/M transition proteinsCEP41 ACTR1A TUBB4B CEP164 TUBGCP3 DYNC1I2 p-T14,Y15,T161-CDK1 OFD1 TUBG1 PAFAH1B1cytoplasmic Cyclin B1Cdc2 complexesTUBB4A CCP110 CEP57 CEP70 p-S177-OPTNAZI1 PCM1 CDK1 PKMYT1NUMA1ADPOFD1 AKAP9 CDC25BNINL centrosome-associated NuMAp-T160-CDK2 CSNK1D p-NINLDCTN2


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  79. Major ML, Lepe R, Costa RH.; ''Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.''; PubMed Europe PMC Scholia
  80. Toyoshima-Morimoto F, Taniguchi E, Nishida E.; ''Plk1 promotes nuclear translocation of human Cdc25C during prophase.''; PubMed Europe PMC Scholia
  81. Yang J, Bardes ES, Moore JD, Brennan J, Powers MA, Kornbluth S.; ''Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.''; PubMed Europe PMC Scholia
  82. Liu XS, Li H, Song B, Liu X.; ''Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.''; PubMed Europe PMC Scholia
  83. Takizawa CG, Morgan DO.; ''Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.''; PubMed Europe PMC Scholia
  84. Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R.; ''XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly.''; PubMed Europe PMC Scholia
  85. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  86. Hagting A, Jackman M, Simpson K, Pines J.; ''Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal.''; PubMed Europe PMC Scholia
  87. Golsteyn RM, Mundt KE, Fry AM, Nigg EA.; ''Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.''; PubMed Europe PMC Scholia
  88. Liu F, Stanton JJ, Wu Z, Piwnica-Worms H.; ''The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114706view16:18, 25 January 2021ReactomeTeamReactome version 75
113151view11:21, 2 November 2020ReactomeTeamReactome version 74
112379view15:31, 9 October 2020ReactomeTeamReactome version 73
101750view12:30, 5 November 2018DeSlOntology Term : 'G2/M transition pathway' added !
101749view12:29, 5 November 2018DeSlOntology Term : 'G2 phase pathway' added !
101282view11:17, 1 November 2018ReactomeTeamreactome version 66
100819view20:47, 31 October 2018ReactomeTeamreactome version 65
100360view19:22, 31 October 2018ReactomeTeamreactome version 64
99905view16:06, 31 October 2018ReactomeTeamreactome version 63
99461view14:38, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
94019view13:51, 16 August 2017ReactomeTeamreactome version 61
93638view11:29, 9 August 2017ReactomeTeamreactome version 61
86753view09:25, 11 July 2016ReactomeTeamreactome version 56
83378view11:04, 18 November 2015ReactomeTeamVersion54
81553view13:05, 21 August 2015ReactomeTeamVersion53
77022view08:32, 17 July 2014ReactomeTeamFixed remaining interactions
76727view12:09, 16 July 2014ReactomeTeamFixed remaining interactions
75762view11:26, 10 June 2014ReactomeTeamReactome 48 Update
75112view14:06, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74759view08:50, 30 April 2014ReactomeTeamReactome46
44913view10:36, 6 October 2011MartijnVanIerselOntology Term : 'cell cycle pathway, mitotic' added !
42077view21:55, 4 March 2011MaintBotAutomatic update
39885view05:54, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTR1A ProteinP61163 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AKAP9 ProteinQ99996 (Uniprot-TrEMBL)
ALMS1 ProteinQ8TCU4 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AZI1 ProteinQ9UPN4 (Uniprot-TrEMBL)
CAKComplexREACT_5717 (Reactome)
CCNA1 ProteinP78396 (Uniprot-TrEMBL)
CCNA2 ProteinP20248 (Uniprot-TrEMBL)
CCNB1 ProteinP14635 (Uniprot-TrEMBL)
CCNB2 ProteinO95067 (Uniprot-TrEMBL)
CCNH ProteinP51946 (Uniprot-TrEMBL)
CCP110 ProteinO43303 (Uniprot-TrEMBL)
CDC25BProteinP30305 (Uniprot-TrEMBL)
CDC25CProteinP30307 (Uniprot-TrEMBL)
CDK1 ProteinP06493 (Uniprot-TrEMBL)
CDK11p58ProteinREACT_16059 (Reactome)
CDK1ProteinP06493 (Uniprot-TrEMBL)
CDK5RAP2 ProteinQ96SN8 (Uniprot-TrEMBL)
CDK7 ProteinP50613 (Uniprot-TrEMBL)
CENPJ ProteinQ9HC77 (Uniprot-TrEMBL)
CEP135 ProteinQ66GS9 (Uniprot-TrEMBL)
CEP152 ProteinO94986 (Uniprot-TrEMBL)
CEP164 ProteinQ9UPV0 (Uniprot-TrEMBL)
CEP192 ProteinQ8TEP8 (Uniprot-TrEMBL)
CEP250 ProteinQ9BV73 (Uniprot-TrEMBL)
CEP250ProteinQ9BV73 (Uniprot-TrEMBL)
CEP290 ProteinO15078 (Uniprot-TrEMBL)
CEP41 ProteinQ9BYV8 (Uniprot-TrEMBL)
CEP57 ProteinQ86XR8 (Uniprot-TrEMBL)
CEP63 ProteinQ96MT8 (Uniprot-TrEMBL)
CEP70 ProteinQ8NHQ1 (Uniprot-TrEMBL)
CEP72 ProteinQ9P209 (Uniprot-TrEMBL)
CEP76 ProteinQ8TAP6 (Uniprot-TrEMBL)
CEP78 ProteinQ5JTW2 (Uniprot-TrEMBL)
CETN2 ProteinP41208 (Uniprot-TrEMBL)
CKAP5 ProteinQ14008 (Uniprot-TrEMBL)
CLASP1 ProteinQ7Z460 (Uniprot-TrEMBL)
CNTRL ProteinQ7Z7A1 (Uniprot-TrEMBL)
CRS kinaseREACT_6373 (Reactome)
CSNK1D ProteinP48730 (Uniprot-TrEMBL)
CSNK1E ProteinP49674 (Uniprot-TrEMBL)
Cdc25REACT_3533 (Reactome)
Cdc25ProteinREACT_6588 (Reactome)
Cdc25ProteinREACT_9309 (Reactome)
Centrosome associated Plk1ComplexREACT_18209 (Reactome)
Centrosomes containing recruited CDK11p58ComplexREACT_17657 (Reactome)
Cyclin A Cdc2ComplexREACT_6461 (Reactome)
Cyclin A phospho-Cdc2ComplexREACT_6613 (Reactome)
Cyclin A phospho-Cdc2ComplexREACT_6620 (Reactome)
Cyclin A phospho-Cdc2ComplexREACT_6644 (Reactome)
Cyclin A phospho-Cdc2ComplexREACT_6673 (Reactome)
Cyclin A phospho-Cdk2ComplexREACT_9177 (Reactome)
Cyclin A phospho-Cdk2ComplexREACT_9267 (Reactome)
Cyclin A phospho-Cdk2ComplexREACT_9292 (Reactome)
Cyclin A1 Cdk2 phosphorylated G2/M transition proteinREACT_23084 (Reactome)
Cyclin A1 phospho-Cdc2ComplexREACT_4408 (Reactome)
Cyclin A2 Cdk2 phosphorylated G2/M transition proteinREACT_22726 (Reactome)
Cyclin A2 phospho-Cdc2ComplexREACT_4651 (Reactome)
Cyclin AProteinREACT_6541 (Reactome)
Cyclin B Cdc2 complexComplexREACT_6447 (Reactome)
Cyclin B phospho-Cdc2ComplexREACT_6524 (Reactome)
Cyclin B1 phospho-Cdc2 ComplexREACT_6474 (Reactome)
Cyclin B1 phospho-Cdc2ComplexREACT_3166 (Reactome)
Cyclin B1 phospho-Cdc2ComplexREACT_6566 (Reactome)
Cyclin B1 phospho-Cdc2ComplexREACT_6704 (Reactome)
Cyclin B2 phospho-Cdc2ComplexREACT_4066 (Reactome)
Cyclin B2 phospho-Cdc2ComplexREACT_6445 (Reactome)
Cyclin BProteinREACT_6593 (Reactome)
DCTN1-2 ProteinQ14203-2 (Uniprot-TrEMBL)
DCTN2 ProteinQ13561 (Uniprot-TrEMBL)
DCTN3ProteinO75935 (Uniprot-TrEMBL)
DYNC1H1 ProteinQ14204 (Uniprot-TrEMBL)
DYNC1I2 ProteinQ13409 (Uniprot-TrEMBL)
DYNLL1 ProteinP63167 (Uniprot-TrEMBL)
E2F1 ProteinQ01094 (Uniprot-TrEMBL)
E2F1/E2F3REACT_9082 (Reactome)
E2F3 ProteinO00716 (Uniprot-TrEMBL)
FGFR1OPProteinO95684 (Uniprot-TrEMBL)
G2/M transition proteinREACT_2998 (Reactome)
G2/M transition proteinsREACT_22572 (Reactome)
G2/M transition proteinsREACT_23060 (Reactome)
GTP MetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HAUS2 ProteinQ9NVX0 (Uniprot-TrEMBL)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
MAPRE1 ProteinQ15691 (Uniprot-TrEMBL)
MNAT1 ProteinP51948 (Uniprot-TrEMBL)
Mature centrosomes enriched in gamma-TURC complexesComplexREACT_15605 (Reactome)
NDE1 ProteinQ9NXR1 (Uniprot-TrEMBL)
NEDD1 ProteinQ8NHV4 (Uniprot-TrEMBL)
NEK2 ProteinP51955 (Uniprot-TrEMBL)
NINL ProteinQ9Y2I6 (Uniprot-TrEMBL)
NUMA1ProteinQ14980 (Uniprot-TrEMBL)
Nlp-depleted centrosomeComplexREACT_18075 (Reactome)
NuMA homodimerComplexREACT_15940 (Reactome)
NuMA-bound microtubulesComplexREACT_18043 (Reactome)
ODF2 ProteinQ5BJF6 (Uniprot-TrEMBL)
OFD1 ProteinO75665 (Uniprot-TrEMBL)
OPTN

RAB8A

GTP		ComplexREACT_161318 (Reactome)
OPTN ProteinQ96CV9 (Uniprot-TrEMBL)
PAFAH1B1ProteinP43034 (Uniprot-TrEMBL)
PCM1 ProteinQ15154 (Uniprot-TrEMBL)
PCNT ProteinO95613 (Uniprot-TrEMBL)
PKMYT1ProteinQ99640 (Uniprot-TrEMBL)
PLK1 ProteinP53350 (Uniprot-TrEMBL)
PLK1ProteinP53350 (Uniprot-TrEMBL)
PLK4 ProteinO00444 (Uniprot-TrEMBL)
PPP1CB ProteinP62140 (Uniprot-TrEMBL)
PPP1R12B-4 ProteinO60237-4 (Uniprot-TrEMBL)
PPP2R1AProteinP30153 (Uniprot-TrEMBL)
PRKACA ProteinP17612 (Uniprot-TrEMBL)
PRKAR2B ProteinP31323 (Uniprot-TrEMBL)
Phospho-Cyclin B1 ComplexREACT_6578 (Reactome)
Phosphorylated Myosin PhosphataseComplexREACT_160462 (Reactome) All known myosin phosphatases consist of PP1 beta and both a large and a small myosin phosphatase targetting (Mypt) subunit. The large Mypt targets PP1 beta to myosin and determines the substrate specifity of the phosphatase. The Large Mypt subunit is encoded by one of three human genes, PPP1R12A (MYPT1), PPP1R12B (MYPT2) and PPP1R12C. Only MYPT1 is represented here. The small subunit is an alternative transcript of MYPT2. The function of the small Mypt subunit remains unclear, but because it is known to interact directly with myosin and the large Mypt it is thought to have an unspecified regulatory role.
PiMetaboliteCHEBI:18367 (ChEBI)
RAB8A GTPComplexREACT_160437 (Reactome)
RAB8A ProteinP61006 (Uniprot-TrEMBL)
SDCCAG8 ProteinQ86SQ7 (Uniprot-TrEMBL)
SFI1 ProteinA8K8P3 (Uniprot-TrEMBL)
SSNA1 ProteinO43805 (Uniprot-TrEMBL)
TUBA1A ProteinQ71U36 (Uniprot-TrEMBL)
TUBA4A ProteinP68366 (Uniprot-TrEMBL)
TUBB ProteinP07437 (Uniprot-TrEMBL)
TUBB4A ProteinP04350 (Uniprot-TrEMBL)
TUBB4B ProteinP68371 (Uniprot-TrEMBL)
TUBG1 ProteinP23258 (Uniprot-TrEMBL)
TUBG2 ProteinQ9NRH3 (Uniprot-TrEMBL)
TUBGCP2 ProteinQ9BSJ2 (Uniprot-TrEMBL)
TUBGCP3 ProteinQ96CW5 (Uniprot-TrEMBL)
TUBGCP4 ProteinQ9UGJ1 (Uniprot-TrEMBL)
TUBGCP5 ProteinQ96RT8 (Uniprot-TrEMBL)
TUBGCP6 ProteinQ96RT7 (Uniprot-TrEMBL)
WEE1ProteinP30291 (Uniprot-TrEMBL)
XPO1ProteinO14980 (Uniprot-TrEMBL)
YWHAE ProteinP62258 (Uniprot-TrEMBL)
YWHAGProteinP61981 (Uniprot-TrEMBL)
active nuclear Cyclin B1 Cdc2 complexesREACT_6519 (Reactome)
cNAP-1 depleted centrosomeComplexREACT_17186 (Reactome)
centrosome containing phosphorylated NlpComplexREACT_17093 (Reactome)
centrosome-associated NuMAComplexREACT_15920 (Reactome)
centrosome-nucleated microtubulesComplexREACT_16122 (Reactome)
centrosomeComplexREACT_15979 (Reactome)
cytoplasmic Cyclin B1 Cdc2 complexesComplexREACT_6372 (Reactome)
gamma-tubulin complexComplexREACT_15704 (Reactome) A current model of the arrangement of subunits within the  TuRC postulates that 6-7 TuSC subcomplexes are held together by  the other Grip proteins, which together form the cap subunits(Reviewed in Wiese and Zheng, 2006).
nuclear Cyclin B1 Cdc2 complexesComplexREACT_6641 (Reactome)
nuclear Cyclin B1 Cdc2 substratesREACT_6526 (Reactome)
nuclear Cyclin B1 phospho-Cdc2 ComplexREACT_6390 (Reactome)
p-4S-CCNB1 ProteinP14635 (Uniprot-TrEMBL)
p-E2F1 ProteinQ01094 (Uniprot-TrEMBL)
p-E2F3 ProteinO00716 (Uniprot-TrEMBL)
p-NINL ProteinQ9Y2I6 (Uniprot-TrEMBL)
p-NINLProteinQ9Y2I6 (Uniprot-TrEMBL)
p-NUMA1 ProteinQ14980 (Uniprot-TrEMBL)
p-NUMA1ProteinQ14980 (Uniprot-TrEMBL)
p-PKMYT1ProteinQ99640 (Uniprot-TrEMBL)
p-S177-OPTNProteinQ96CV9 (Uniprot-TrEMBL)
p-S198-CDC25CProteinP30307 (Uniprot-TrEMBL)
p-S473-PPP1R12A ProteinO14974 (Uniprot-TrEMBL)
p-S53-WEE1ProteinP30291 (Uniprot-TrEMBL)
p-T14,T161-CDK1 ProteinP06493 (Uniprot-TrEMBL)
p-T14,Y15,T161-CDK1 ProteinP06493 (Uniprot-TrEMBL)
p-T14-CDK1 ProteinP06493 (Uniprot-TrEMBL)
p-T160-CDK2 ProteinP24941 (Uniprot-TrEMBL)
p-T161-CDK1 CCNB1ComplexREACT_6540 (Reactome)
p-T161-CDK1 ProteinP06493 (Uniprot-TrEMBL)
p-T210-PLK1ProteinP53350 (Uniprot-TrEMBL)
phospho-Cdc2ComplexREACT_6681 (Reactome)
phospho-Cyclin B1ComplexREACT_6646 (Reactome)
phospho-G2/M transition proteinREACT_3843 (Reactome)
phospho-G2/M transition proteinREACT_4658 (Reactome)
phospho-cyclin B1ComplexREACT_6436 (Reactome)
phosphorylated nuclear Cyclin B1 Cdc2 substratesREACT_8297 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowREACT_15386 (Reactome)
ADPArrowREACT_15543 (Reactome)
ADPArrowREACT_160293 (Reactome)
ADPArrowREACT_1627 (Reactome)
ADPArrowREACT_2119 (Reactome)
ADPArrowREACT_406 (Reactome)
ADPArrowREACT_6139 (Reactome)
ADPArrowREACT_6178 (Reactome)
ADPArrowREACT_6217 (Reactome)
ADPArrowREACT_6314 (Reactome)
ADPArrowREACT_6327 (Reactome)
ADPArrowREACT_6338 (Reactome)
ADPArrowREACT_6342 (Reactome)
ADPArrowREACT_6353 (Reactome)
ADPArrowREACT_852 (Reactome)
ADPArrowREACT_9023 (Reactome)
ATPREACT_15386 (Reactome)
ATPREACT_15543 (Reactome)
ATPREACT_160293 (Reactome)
ATPREACT_1627 (Reactome)
ATPREACT_2119 (Reactome)
ATPREACT_406 (Reactome)
ATPREACT_6139 (Reactome)
ATPREACT_6178 (Reactome)
ATPREACT_6217 (Reactome)
ATPREACT_6314 (Reactome)
ATPREACT_6327 (Reactome)
ATPREACT_6338 (Reactome)
ATPREACT_6342 (Reactome)
ATPREACT_6353 (Reactome)
ATPREACT_852 (Reactome)
ATPREACT_9023 (Reactome)
CAKmim-catalysisREACT_6139 (Reactome)
CAKmim-catalysisREACT_6314 (Reactome)
CDC25CREACT_2119 (Reactome)
CDK11p58ArrowREACT_15470 (Reactome)
CDK11p58REACT_15401 (Reactome)
CDK1REACT_6216 (Reactome)
CDK1REACT_6308 (Reactome)
CEP250ArrowREACT_15313 (Reactome)
CRS kinasemim-catalysisREACT_6353 (Reactome)
Cdc25mim-catalysisREACT_6175 (Reactome)
Cdc25mim-catalysisREACT_6255 (Reactome)
Cdc25mim-catalysisREACT_6257 (Reactome)
Cdc25mim-catalysisREACT_6294 (Reactome)
Cyclin A Cdc2REACT_6342 (Reactome)
Cyclin A phospho-Cdc2ArrowREACT_6139 (Reactome)
Cyclin A phospho-Cdc2ArrowREACT_6294 (Reactome)
Cyclin A phospho-Cdc2ArrowREACT_6327 (Reactome)
Cyclin A phospho-Cdc2REACT_6139 (Reactome)
Cyclin A phospho-Cdc2REACT_6294 (Reactome)
Cyclin A phospho-Cdc2REACT_6327 (Reactome)
Cyclin A phospho-Cdk2ArrowREACT_9023 (Reactome)
Cyclin A phospho-Cdk2REACT_9021 (Reactome)
Cyclin A phospho-Cdk2REACT_9023 (Reactome)
Cyclin A phospho-Cdk2mim-catalysisREACT_9023 (Reactome)
Cyclin A1 Cdk2 phosphorylated G2/M transition proteinArrowREACT_406 (Reactome)
Cyclin A1 phospho-Cdc2mim-catalysisREACT_406 (Reactome)
Cyclin A2 Cdk2 phosphorylated G2/M transition proteinArrowREACT_1627 (Reactome)
Cyclin A2 phospho-Cdc2mim-catalysisREACT_1627 (Reactome)
Cyclin AREACT_6308 (Reactome)
Cyclin B Cdc2 complexREACT_6217 (Reactome)
Cyclin B phospho-Cdc2ArrowREACT_6217 (Reactome)
Cyclin B1 phospho-Cdc2 ArrowREACT_6314 (Reactome)
Cyclin B1 phospho-Cdc2 REACT_6178 (Reactome)
Cyclin B1 phospho-Cdc2ArrowREACT_6178 (Reactome)
Cyclin B1 phospho-Cdc2ArrowREACT_6257 (Reactome)
Cyclin B1 phospho-Cdc2REACT_6255 (Reactome)
Cyclin B1 phospho-Cdc2REACT_6257 (Reactome)
Cyclin B1 phospho-Cdc2REACT_6353 (Reactome)
Cyclin B2 phospho-Cdc2ArrowREACT_6175 (Reactome)
Cyclin B2 phospho-Cdc2REACT_6175 (Reactome)
Cyclin B2 phospho-Cdc2mim-catalysisREACT_852 (Reactome)
Cyclin BREACT_6216 (Reactome)
E2F1/E2F3REACT_9021 (Reactome)
G2/M transition proteinREACT_852 (Reactome)
G2/M transition proteinsREACT_1627 (Reactome)
G2/M transition proteinsREACT_406 (Reactome)
H2OREACT_160137 (Reactome)
H2OREACT_6175 (Reactome)
H2OREACT_6255 (Reactome)
H2OREACT_6257 (Reactome)
H2OREACT_6294 (Reactome)
NUMA1REACT_15543 (Reactome)
Nlp-depleted centrosomeArrowREACT_15440 (Reactome)
NuMA homodimerREACT_15294 (Reactome)
NuMA homodimerREACT_15444 (Reactome)
OPTN

RAB8A

GTP		REACT_160293 (Reactome)
PKMYT1mim-catalysisREACT_6342 (Reactome)
PLK1ArrowREACT_160137 (Reactome)
PLK1REACT_15470 (Reactome)
PLK1mim-catalysisREACT_15386 (Reactome)
PLK1mim-catalysisREACT_1944 (Reactome)
PLK1mim-catalysisREACT_2119 (Reactome)
PLK1mim-catalysisREACT_414 (Reactome)
Phospho-Cyclin B1 ArrowREACT_6353 (Reactome)
Phosphorylated Myosin Phosphatasemim-catalysisREACT_160137 (Reactome)
PiArrowREACT_160137 (Reactome)
PiArrowREACT_6175 (Reactome)
PiArrowREACT_6255 (Reactome)
PiArrowREACT_6257 (Reactome)
PiArrowREACT_6294 (Reactome)
RAB8A GTPArrowREACT_160293 (Reactome)
REACT_15294 (Reactome) NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al., 1996; Gueth-Hallonet et al., 1998; Harborth et al., 1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains.
REACT_15313 (Reactome) The centrosomal protein C-Nap1 is thought to play an important role in centrosome cohesion during interphase (Fry et al.,1998). At the onset of mitosis, when centrosomes separate to form the bipolar spindle, C-Nap1 dissociates (Mayor et al., 2000). Dissociation of C-Nap1 from mitotic centrosomes appears to be regulated by phosphorylation (Mayor et al. 2002).
REACT_15386 (Reactome) Phosphorylation of NlP by Plk1 regulates the interaction of Nlp with both centrosomes and ?-TuRCs (Casenghi et al., 2003).
REACT_15401 (Reactome) CDK11p58 is a kinase that is active during mitosis when it associates with centrosomes, and has a crucial role in centrosome maturation and bipolar spindle formation (Petretti et al., 2006). CDK11p58 facilitates microtubule nucleation and is required for the recruitment of Aurora and Plk1 to the centrosome (Petretti et al., 2006).
REACT_15440 (Reactome) Mitotic activation of Plk1 is required for efficient displacement of Nlp from the centrosome (Casenghi et al., 2003).
REACT_15444 (Reactome) The mechanism by which human NuMA is translocated to the centrosomes has not yet been determined.
REACT_15467 (Reactome) Microtubule nucleation at the centrosome is mediated by the gamma tubulin ring complex (gamma TuRC) (reviewed in Raynaud-Messina and Merdes, 2006; Wiese and Zheng, 2006). In humans, this large complex contains the tubulin superfamily member gamma-tubulin, five gamma complex proteins (GCP2-GPC6) and NEDD1/GCP-WD. A current model of the arrangement of subunits within the gamma-TuRC proposes that 6-7 TuSC subcomplexes are held together by the other Grip proteins (at an unknown stoichiometry), which together form the cap subunits. In many animal cells, the recruitment of gamma-tubulin complexes to the centrosome rapidly increases (3–5 fold ) before mitosis  to support the formation of new spindle microtubules (Khodjakov and Rieder 1999).  NEDD1/GCP-WD  plays  an essential role in recruitment of these complexes to the centrosomes (Haren et al., 2006;  Luders et al., 2006) and to the mitotic spindle (Luders et al., 2006). GCP-WD/NEDD1  associates directly with the  gamma-TuRC.  The carboxy-terminal half  binds to the gamma-TuRC whereas the amino-terminal half, corresponding to the WD-repeat domain,  is responsible for its attachment to the centrosome (Haren et al., 2006). Additional centrosomal proteins have also been implicated in the docking of gamma-TuRC to the centrosomes. CG-NAP/AKAP450  and kendrin  are  necessary for the initiation of microtubule nucleation and interact  with GCP2/GCP3 and GCP2, respectively (Takahashi et al., 2002).  Pericentrin  plays an important role in  microtubule organization in mitotic cells and anchors gamma- TuRC through domains that bind GCP2 and GCP3  (Zimmerman  et al. 2004). Ninein localizes to the centriole via its C-terminus and interacts with gamma-tubulin-containing complexes via its N-terminus.
REACT_15470 (Reactome) Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007).
REACT_15543 (Reactome) After the initiation of DNA condensation during mitosis, NuMA is phosphorylated by Cdc2 kinase and transported rapidly to the centrosomal region (Hsu and Yeh, 1996). Another phosphorylation event occurs when NuMA associates with the mitotic spindle (Gaglio et al., 1995; Hsu and Yeh, 1996). While p34cdc2/cyclin B-dependent phosphorylation appears to plays an essential role in the targeting of NuMA to the spindle apparatus (Compton and Luo, 1995)(Hsu and Yeh, 1996), there may be additional protein kinases that promote the release of NuMA from the nuclear compartment at nuclear envelope breakdown (Saredi et al., 1997).
REACT_160137 (Reactome) The myosin phosphatase complex can dephosphorylate PLK1 threonine residue T210 and inactivate PLK1 (Yamashiro et al. 2008). Myosin phosphatase is activated through phosphorylation of its PPP1R12A (MYPT1) subunit. Several kinases, including CDK1 (Yamashiro et al. 2008) and LATS1 (Chiyoda et al. 2012) have been implicated in myosin phosphatase activation, but the position and temporal order of key PPP1R12A phosphorylations need to be investigated further. Phosphorylated OPTN (optineurin) is able to bind PPP1R12A (MYPT1) and positively regulates PLK1 dephosphorylation by myosin phosphatase, posibly by facilitating PPP1R12A phosphorylation and myosin phosphatase activation (Kachaner et al. 2012).
REACT_160188 (Reactome) PLK1 is induced in S phase and can be find in both cytosol and nucleus in S and G2 phases of the cell cycle. PLK1 possesses a bipartite nuclear localization signal (NLS) that enables it to enter the nucleus (Taniguchi et al. 2002).
REACT_160281 (Reactome) Phosphorylation of OPTN (optineurin) on serine S177 by PLK1 promotes translocation of OPTN to the nucleus (Kachaner et al. 2012).
REACT_160293 (Reactome) Activated PLK1 phosphorylates OPTN (optineurin) on serine residue S177. Phosphorylation at S177 disrupts OPTN binding to Golgi-membrane localized RAB8A (Kachaner et al. 2012).
REACT_1627 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'G2/M transition protein' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phospho-G2/M transition protein' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'cyclin-dependent protein kinase activity' of 'Cyclin A2:Cdc2'.

REACT_1944 (Reactome) *Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . **Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. ** Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry.
REACT_2119 (Reactome) It has been shown that Xenopus polo homolog,Plx1, directly phosphorylates and activates Cdc25C, which in turn dephosphoryates and activates Cdc2. This step is critical for the onset of mitosis. Since Plx1-dependent Cdc25C phosphorylation occurs in the absence of Cdc2 activity, it is likely that Plx1 is a triggering kinase, which leads to the activation of Cdc2 and therefore the normal onset of mitosis.
REACT_406 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'G2/M transition protein' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phospho-G2/M transition protein' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'cyclin-dependent protein kinase activity' of 'Cyclin A1:Cdc2'.

REACT_414 (Reactome) At mitotic entry Plk1 phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Myt1, functions in a feedback loop and phosphorylates and further inhibits Myt1.
REACT_6139 (Reactome) Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).
REACT_6156 (Reactome) The localization of the Cdc25A, B and C proteins is dynamic involving the shuttling of these proteins between the nucleus and the cytoplasm. Sequences in these proteins mediate both nuclear export and import (Kallstrom et al., 2005; Lindqvist et al., 2004; Graves et al, 2001; Takizawa and Morgan, 2000).
REACT_6163 (Reactome) Cdc25B shuttles between the nucleus and the cytoplasm. Translocation out of the nucleus involves a nuclear export sequence in the N-terminus of Cdc25B (Lindqvist et al., 2004).
REACT_6175 (Reactome) At the beginning of this reaction, 1 molecule of 'Cyclin B2:phospho-Cdc2(Thr 14, Thr 161)', and 1 molecule of 'H2O' are present. At the end of this reaction, 1 molecule of 'Cyclin B2:phospho-Cdc2(Thr 161)', and 1 molecule of 'Orthophosphate' are present.

This reaction takes place in the 'cytosol' and is mediated by the 'phosphoprotein phosphatase activity' of 'Cdc25'.

REACT_6178 (Reactome) Wee1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 on tyrosine 15 inactivating the complex.
REACT_6183 (Reactome) During interphase, cyclin B1 shuttles continuously in and out of the nucleus. The cyclin B cytoplasmic retention sequence (CRS), which is responsible for its interphase cytoplasmic localization, functions as a nuclear export sequence (Yang et al., 1998).
REACT_6216 (Reactome) Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site.
REACT_6217 (Reactome) Myt1, which localizes preferentially to the endoplasmic reticulum and Golgi complex, phosphorylates Cdc2 on threonine 14 ( Liu et al., 1997).
REACT_6255 (Reactome) Following its translocation to the nucleus, Cdc25 dephosphorylates and activates nuclear cyclin B1:Cdc2 complexes (Strausfeld et al., 1991).
REACT_6257 (Reactome) Activation of the mitotic cyclin:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2. This dephosphorylation is achieved by the activity of the Cdc25 family of phosphatases. The Cdc25 members, Cdc25A, Cdc25B, and Cdc25C are kept inactive during interphase and are activated at the G2/M transition. Cyclin B1:Cdc2 itself appears to participate in the full activation of Cdc25 in a process that involves an amplication loop (see Wolfe and Gould, 2004). The initial activation of the cyclin B1-Cdc2 complex occurs in the cytoplasm in prophase (Jackman et al., 2003). Cdc25B, which is present at highest concentrations in the cytoplasm at this time, is thought to trigger the activation of cyclin B1-Cdc2 (Lindqvist et al. 2004; Honda et al., 1993). Active cyclin B:Cdc2 then phosphorylates and activates Cdc25C and stabilizes Cdc25A (Strausfeld et al., 1994; Hoffman et al.,1993; Mailand et al, 2002). This creates positive feedback loops that allows Cdc25A and Cdc25C to dephosphorylate and further activate Cdc2.
REACT_6276 (Reactome) Cyclin A:Cdc2 complexes translocate to the nucleus in G1 and may associate with condensing chromosomes in prophase (Pines and Hunter 1991).
REACT_6279 (Reactome) During interphase, phopshorylated Cdc25C is associated with 14-3-3 proteins preventing nuclear import. At the onset of mitosis, dephosphorylation of Cdc25C and dissociation of 14-3-3 increases the rate of import (see Takizawa and Morgan, 2000)
REACT_6294 (Reactome) Activation of the mitotic cyclin:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2. This dephosphorylation is achieved by the activity of the Cdc25 family of phosphatases. The Cdc25 members, Cdc25A, Cdc25B, and Cdc25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004)
REACT_6308 (Reactome) Cyclin A is synthesized and associates with Cdc2 in G1. Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active sites are blocked by a portion of the CDK molecule itself. Binding to their corresponding cyclin partner results in a conformational change that partially exposes the active site.
REACT_6314 (Reactome) Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. Cyclin B:Cdc2 complexes have considerably low activity in the absence of CAK mediated phosphorylation (Desai et al 1995).
REACT_6327 (Reactome) The human Wee1 kinase phosphorylates Cdc2 on tyrosine 15 inactivating the cyclin:CDK complex (Watanabe et al., 1995).
REACT_6338 (Reactome) A description of the mitotic proteins targeted by the mitotic cyclin:CDK complexes will be covered in a later release.
REACT_6342 (Reactome) Myt1, which localizes preferentially to the endoplasmic reticulum and Golgi complex, phosphorylates Cdc2 on threonine 14 ( Liu et al., 1997).
REACT_6343 (Reactome) The rapid translocation of cyclin B1:Cdc2 from the cytoplasm to the nucleus at the onset of mitosis is a result of an increase in the rate of import and, likely, a decreased rate of export. The increased rate of nuclear import is dependent upon phosphorylation of the CRS which creates a nuclear import signal in the amino terminus of cyclin B1 (Hagting et al, 1999).
REACT_6345 (Reactome) During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).
REACT_6353 (Reactome) At the onset of mitosis, cyclin B is phosphorylated in the CRS sequence which creates a nuclear import signal in the amino terminus. The kinase(s) responsible for this phosphorylation are not yet known (Hagting et al., 1999).
REACT_852 (Reactome) Substrate specificity of cyclin B:Cdk1 complexes is primarily conferred by their subcellular localization (Draviam et al., 2001).
Cyclin B1 is primarily cytoplasmic but shuttles continuously between the nucleus and the cytoplasm during interphase (Hagting et al. 1998 Down; Toyoshima et al. 1998 Down; Yang et al. 1998 Down). At the end of prophase, it abruptly translocates into the nucleus (Furuno et al. 1999 Down; Hagting et al. 1999 Down) and then associates with mitotic apparatus (Pines and Hunter 1991 Down; Hagting et al. 1998 Down; Clute and Pines 1999 Down). Cyclin B2 is primarily associated with the Golgi apparatus during interphase and mitosis (Jackman et al. 1995 Down; Brandeis et al. 1998 Down). Cyclin B1–CDK1 promotes chromosome condensation, reorganization microtubule reorgnization, and disassembly of the nuclear lamina and the Golgi apparatus. Cyclin B2–CDK1 functions in disassembly of the Golgi apparatus (Draviam et al., 2001).


REACT_9021 (Reactome) In G2, the cyclin A:Cdk2 complex associates with E2F1 and E2F3.
REACT_9023 (Reactome) In G2 Cdk2, in association with cyclin A, phosphorylates E2F1 and E2F3 resulting in the inactivation and possibly degradation of these two transcription factors (Dynlacht et al., 1994; Krek et al., 1994).
WEE1mim-catalysisREACT_6178 (Reactome)
WEE1mim-catalysisREACT_6327 (Reactome)
XPO1ArrowREACT_6183 (Reactome)
active nuclear Cyclin B1 Cdc2 complexesmim-catalysisREACT_6338 (Reactome)
cNAP-1 depleted centrosomeArrowREACT_15313 (Reactome)
centrosome containing phosphorylated NlpArrowREACT_15386 (Reactome)
centrosome-nucleated microtubulesREACT_15294 (Reactome)
centrosome-nucleated microtubulesREACT_15444 (Reactome)
centrosomeREACT_15386 (Reactome)
centrosomeREACT_15401 (Reactome)
centrosomeREACT_15467 (Reactome)
centrosomeREACT_15470 (Reactome)
gamma-tubulin complexREACT_15467 (Reactome)
nuclear Cyclin B1 Cdc2 substratesREACT_6338 (Reactome)
nuclear Cyclin B1 phospho-Cdc2 REACT_6314 (Reactome)
p-NINLArrowREACT_15440 (Reactome)
p-NUMA1ArrowREACT_15543 (Reactome)
p-S177-OPTNArrowREACT_160137 (Reactome)
p-S177-OPTNArrowREACT_160293 (Reactome)
p-S198-CDC25CArrowREACT_2119 (Reactome)
p-T161-CDK1 CCNB1ArrowREACT_6255 (Reactome)
p-T161-CDK1 CCNB1mim-catalysisREACT_15543 (Reactome)
p-T210-PLK1REACT_160137 (Reactome)
p-T210-PLK1mim-catalysisREACT_160293 (Reactome)
phospho-Cdc2ArrowREACT_6342 (Reactome)
phospho-G2/M transition proteinArrowREACT_1627 (Reactome)
phospho-G2/M transition proteinArrowREACT_852 (Reactome)
phosphorylated nuclear Cyclin B1 Cdc2 substratesArrowREACT_6338 (Reactome)
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