Hair follicle development: organogenesis - stage 2 of 3 (Homo sapiens)

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PlacodeDermal CondensateoverexpressionNCAMLEF1TP63CDH1SNAI1FOXI3Activin ARUNX2CCND1Hair BudShapeFZD1NF-kBWntPathwayEDAREDAEdaPathwayShhPathwaySHHEDARB-cateninEDASHHLRP5/6BMP sPTCHSMOShhPathwaySHHPTCH1SMONOGPDGFRAPDGFPDGFNogginPTCH1CCND1GJB6PlacodeDowngrowthLEF1FGFR2GLI2CCND2ITGB1PrimaryCiliaRas-MAPKPathwayTgf-B2PathwayGLI1GLI sFGFWNT5AWNT5AMYCLaminin-511


Description

Hair follicle development is a process dependent on epithelial-mesenchymal transitions orchestrated by many signaling pathways. Here we find one of three complex regulatory pathways assembled from a text mining approach portraying the development of this key mammal-specific structure.

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Ontology Terms

 

Bibliography

  1. Fantauzzo KA, Kurban M, Levy B, Christiano AM; ''Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  2. Nowak JA, Polak L, Pasolli HA, Fuchs E; ''Hair follicle stem cells are specified and function in early skin morphogenesis.''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  3. Hammerschmidt B, Schlake T; ''Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs.''; Dev Biol, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129075view14:33, 10 March 2024EweitzModified title
129072view14:22, 10 March 2024EweitzAdd pathway series header
129070view13:52, 10 March 2024EweitzIdentify EDA pathway
129069view03:11, 10 March 2024EweitzStandardize case
117746view12:46, 22 May 2021EweitzModified title
115446view11:29, 19 February 2021DeSlChanged two "PW nodes" to textlabels (since these aren't PWs).
115445view11:24, 19 February 2021DeSlAdded PW ID for primary cilia
115439view10:58, 19 February 2021DeSlSmall textual change in title
115438view10:57, 19 February 2021DeSlOntology Term : 'hair follicle cell' added !
115437view10:56, 19 February 2021DeSlAdded annotations for some PW nodes
115435view10:52, 19 February 2021DeSlConnected last unconnected line
115434view10:51, 19 February 2021DeSlAdded ID for Activin A (aka inhibin beta A)
115433view10:49, 19 February 2021DeSlRemoved email address + last modified item
115432view10:48, 19 February 2021DeSlAdded linkouts to other two PWs
90188view19:51, 21 October 2016Khanspersfixed unconnected
88630view14:41, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82284view23:10, 23 September 2015AlexanderPicochaging Rectangle to RoundedRectangle to resolve pvjs errors
82273view23:35, 22 September 2015AlexanderPicoReverted to version '03:29, 7 January 2015' by AlexanderPico
82272view23:35, 22 September 2015AlexanderPicochanging double lined nuclei for pvjs compatibility
82271view23:27, 22 September 2015AlexanderPicochanging double line to solid for pvjs compatibility
78519view10:29, 7 January 2015MaintBotadded missing graphIds
77664view07:43, 4 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77315view22:29, 14 August 2014DanieltrinunesModified description
77308view22:06, 14 August 2014DanieltrinunesModified title
77307view22:05, 14 August 2014DanieltrinunesNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Activin AGeneProduct
B-cateninGeneProductP35222 (Uniprot-SwissProt)
BMP sProteinP12644 (Uniprot-SwissProt)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CCND2ProteinP30279 (Uniprot-SwissProt)
CDH1GeneProductP12830 (Uniprot-SwissProt)
EDAProteinQ92838 (Uniprot-SwissProt)
EDARProteinQ9UNE0 (Uniprot-SwissProt)
Eda PathwayPathway
FGFProteinP05230 (Uniprot-SwissProt)
FGFR2ProteinP21802 (Uniprot-SwissProt)
FOXI3GeneProductA8MTJ6 (Uniprot-SwissProt)
FZD1ProteinQ9UP38 (Uniprot-SwissProt)
GJB6GeneProductO95452 (Uniprot-SwissProt)
GLI sProteinP08151 (Uniprot-SwissProt)
GLI1ProteinP08151 (Uniprot-TrEMBL)
GLI2ProteinP10070 (Uniprot-SwissProt)
Hair Bud Shape
ITGB1ProteinP05556 (Uniprot-SwissProt)
LEF1ProteinQ9UJU2 (Uniprot-SwissProt)
LRP5/6ProteinO75197 (Uniprot-SwissProt)
Laminin-511ProteinO15230 (Uniprot-TrEMBL)
MYCProteinP01106 (Uniprot-SwissProt)
NCAMProteinP13591 (Uniprot-TrEMBL)
NF-kBProteinP19838 (Uniprot-SwissProt)
NOGProteinQ9BZE4 (Uniprot-SwissProt)
NogginProteinQ9BZE4 (Uniprot-SwissProt)
PDGFProteinP04085 (Uniprot-TrEMBL)
PDGFRAProteinP16234 (Uniprot-SwissProt)
PTCH1ProteinQ13635 (Uniprot-SwissProt)
PTCHProteinQ13635 (Uniprot-SwissProt)
Placode Downgrowth
Primary Cilia
RUNX2GeneProductQ13950 (Uniprot-SwissProt)
Ras-MAPK PathwayPathway
SHHProteinQ15465 (Uniprot-SwissProt)
SMOProteinQ99835 (Uniprot-SwissProt)
SNAI1ProteinO95863 (Uniprot-SwissProt)
Shh PathwayPathway
TP63GeneProductQ9H3D4 (Uniprot-SwissProt)
Tgf-B2 PathwayPathway
WNT5AProteinP41221 (Uniprot-SwissProt)
Wnt PathwayPathway

Annotated Interactions

No annotated interactions

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