Dual hijack model of Vif in HIV infection (Homo sapiens)

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1Ubiquitin ligationGene expressionRBX2CUL5A3GELOBVifRUNX1ELOCCBFBUBBCBFBUbE2VifCBFBVif


Description

By hijacking CBF-b, Vif is manipulating the ubquitination machinery and adversely effecting host transcriptional regulation. Vif: Viral infectivity factor, HIV protein.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fraser JS, Gross JD, Krogan NJ; ''From systems to structure: bridging networks and mechanism.''; Mol Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
102277view07:14, 17 December 2018EgonwUpdated Uniprot data source name.
102275view22:50, 16 December 2018Andraupdate vif ids
102274view22:42, 16 December 2018Andraadd uniprot ID
102222view20:56, 11 December 2018KhanspersModified description
102221view20:56, 11 December 2018KhanspersModified description
97835view06:45, 10 June 2018EgonwModified description
97680view13:18, 1 June 2018AMTanOntology Term : 'human immunodeficiency virus infectious disease' added !
87896view12:52, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
85021view19:19, 5 April 2016KhanspersQuick edit to datanode annotation or property
81234view20:25, 6 August 2015Khansperslayout update
81233view19:36, 6 August 2015KhanspersModified description
81232view19:30, 6 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A3GGeneProductENSG00000239713 (Ensembl)
CBFBGeneProductENSG00000067955 (Ensembl)
CUL5GeneProductENSG00000166266 (Ensembl)
E2GeneProductENSG00000067955 (Ensembl)
ELOBGeneProductENSG00000103363 (Ensembl)
ELOCGeneProductENSG00000154582 (Ensembl)
RBX2GeneProduct
RUNX1GeneProductENSG00000159216 (Ensembl)
UBBGeneProductENSG00000170315 (Ensembl)
VifGeneProduct

Annotated Interactions

No annotated interactions

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