Liver X receptor pathway (Homo sapiens)

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32OtherMulti-drug resistanceTranscriptionTranscription factorsDrug and steroid metabolismNR1H342LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA5, 20RXRA5, 20ABCG8CYP3A44235ABCG542CYP2B6CYP7A13535SREBF135FASNLXR target genes35SCD


Description

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116465view10:06, 7 May 2021EweitzModified title
106631view20:55, 12 September 2019KhanspersModified description
105637view05:06, 10 August 2019KhanspersModified description
94790view23:00, 5 October 2017AlexanderPicoConverted lines
94780view22:20, 5 October 2017AlexanderPicoConverted lines and reconnected interactions
88692view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82709view09:24, 23 October 2015EgonwMore specific ChEBI identifier.
79886view13:20, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79885view12:40, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79599view05:44, 27 March 2015EgonwFixed a bunch of PubMed references (character encodings, messed up Biopax/XML).
79598view05:36, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79553view12:22, 25 March 2015FehrhartUpdate of GenIDs and comments
79542view15:07, 24 March 2015RiannefijtenModified description
79541view15:06, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed pathway nodes to labels
79484view13:05, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78513view10:29, 7 January 2015MaintBotadded missing graphIds
78254view22:06, 17 December 2014KhanspersModified title
78214view15:03, 14 December 2014MaintBotModified title
78213view14:58, 14 December 2014EgonwChanged GPML schema.
78087view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCG5GeneProduct64240 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8GeneProduct64241 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 8
CYP2B6GeneProduct1555 (Entrez Gene) cytochrome P450, family 2, subfamily B, polypeptide 6
CYP3A4GeneProduct1576 (Entrez Gene) cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
FASNGeneProduct2194 (Entrez Gene) fatty acid synthase
LXR ligandMetaboliteCHEBI:86029 (ChEBI) T3
LigandMetaboliteCHEBI:86029 (ChEBI)
NR1H3GeneProduct10062 (Entrez Gene) nuclear receptor subfamily 1, group H, member 3
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
SCDGeneProduct6319 (Entrez Gene)
SREBF1GeneProduct6720 (Entrez Gene) sterol regulatory element binding transcription factor 1

Annotated Interactions

No annotated interactions

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