IL-6 signaling pathway (Canis familiaris)

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UbiquitinationLigandEndosomeProteins in a complex interactionDDMTMethylationERDDNucleusCYEnzyme complexDeubiquitinationInhibitionCY->NUD(Protein-Protein interaction)PMRecruitmentGODDCY->NUEndoplasmic reticulumComplex formationDECPlasma membraneActivationPalmitoylationDDDephosphorylationMolecule in the pathwayDemethylationPhosphorylationCY->NUCY->NUExtracellularDTranslocationAutophosphorylationNUReceptorCytoplasmGolgi apparatusDesumoylationGlycosylationEarly EndosomesAcetylationDSumoylationCY->NUDMolecular associationENMitochondrionGene SymbolReactions through unknown mechanisms/moleculesAccession Number: NetPath 18DeacetylationCY->NUControlDCY->ENProteolytic cleavagePPP2R1AVAV1PPP2R3BNCOA1MAP2K6HNF1AMAPK1SGK1EIF2APPP2R5ESTAT3PPP2R1BCEBPBIL6PPP2R4GSK3BJAK2MAP2K4STAT3ERBB3STAT1PPP2R2CCD40EIF4EBP1MAP3K4GAB2JAK1RAF1CREBBPMAPTIL6RINPP5DGAB1INPPL1STAT3EP300FOXO4PPP2CBCASP9MAPK14PPP2R3AHSPB1SHC1PPP2R5AAKT1EIF4ESTAT1LOC487309CEBPBPRKCDSTAT3FESIL6RBMXSTAT5AJUNPPP2R2BSTAT3LOC480438TYK2MAP2K2NLKPPP2R5BIL6STRB1LYNNFKB1CDK9MAPK8GRB2FOXO3AHCKRAC1STAT5BPPP2CAFOXO1SGK1MAPK14HRASBADPPP2R5DARPLCG1FGRPTK2IL6STMAP2K1NFKB1MAPK3TECPIK3R1STAT3SOS1BTKSTAT1PPP2R2AFOSIL6CDK5R1STAT1PTK2BPIK3R2RPS6KA2MAPKAPK2PPP2R5CMAP3K7PXNRPS6KB1CASP3MAP3K7STAT3PTPN11STAT3DAXXERBB2SOCS3FYNCDK5


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 91% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
118000view11:25, 23 May 2021EweitzModified title
86937view13:07, 15 July 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
68562view22:47, 5 July 2013MaintBotUpdated to 2013 gpml schema
40720view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33999view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
32542view13:03, 17 August 2009MaintBotFixed text labels
31240view19:48, 13 August 2009MaintBotFixed text labels
30663view22:37, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
ARGeneProduct403588 (Entrez Gene)
BADGeneProduct483763 (Entrez Gene)
BMXGeneProduct491750 (Entrez Gene)
BTKGeneProduct492019 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CD40GeneProduct403469 (Entrez Gene)
CDK5GeneProduct475537 (Entrez Gene)
CDK5R1GeneProduct491154 (Entrez Gene)
CDK9GeneProduct491325 (Entrez Gene)
CEBPBGeneProduct
CREBBPGeneProduct479866 (Entrez Gene)
DAXXGeneProduct474873 (Entrez Gene)
EIF2AGeneProduct477112 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
EP300GeneProduct
ERBB2GeneProduct403883 (Entrez Gene)
ERBB3GeneProduct481105 (Entrez Gene)
FESGeneProduct609483 (Entrez Gene)
FGRGeneProduct487341 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FOXO3AGeneProduct
FOXO4GeneProduct491946 (Entrez Gene)
FYNGeneProduct475032 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GAB2GeneProduct485167 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
HCKGeneProduct485828 (Entrez Gene)
HNF1AGeneProduct486303 (Entrez Gene)
HRASGeneProduct
HSPB1GeneProduct403979 (Entrez Gene)
IL6GeneProduct403985 (Entrez Gene)
IL6RGeneProduct612271 (Entrez Gene)
IL6STGeneProduct403545 (Entrez Gene)
INPP5DGeneProduct
INPPL1GeneProduct485209 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LOC480438GeneProduct480438 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
LYNGeneProduct477886 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP2K4GeneProduct489508 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAP3K7GeneProduct474996 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MAPTGeneProduct480488 (Entrez Gene)
NCOA1GeneProduct475684 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NLKGeneProduct491160 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PLCG1GeneProduct485874 (Entrez Gene)
PPP2CAGeneProduct403608 (Entrez Gene)
PPP2CBGeneProduct482873 (Entrez Gene)
PPP2R1AGeneProduct484335 (Entrez Gene)
PPP2R1BGeneProduct479444 (Entrez Gene)
PPP2R2AGeneProduct477374 (Entrez Gene)
PPP2R2BGeneProduct478053 (Entrez Gene)
PPP2R2CGeneProduct610262 (Entrez Gene)
PPP2R3AGeneProduct485672 (Entrez Gene)
PPP2R3BGeneProduct607103 (Entrez Gene)
PPP2R4GeneProduct491303 (Entrez Gene)
PPP2R5AGeneProduct490280 (Entrez Gene)
PPP2R5BGeneProduct483755 (Entrez Gene)
PPP2R5CGeneProduct480436 (Entrez Gene)
PPP2R5DGeneProduct481806 (Entrez Gene)
PPP2R5EGeneProduct480349 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PXNGeneProduct486299 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SGK1GeneProduct403647 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
TECGeneProduct482140 (Entrez Gene)
TYK2GeneProduct476714 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)

Annotated Interactions

No annotated interactions
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