TNF-alpha NF-kB signaling pathway (Danio rerio)

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UbiquitinationGOCY ->NUDesumoylationProteolytic cleavageDPMPalmitoylationNURecruitmentCytoplasmCYMTInhibitionProteins in a complex interactionActivationCY ->NUENLigandControlERReaction through unknown mechanisms/moleculesGolgi apparatusEndosome(Protein-protein interaction)CY ->NUCY ->NUEndoplasmic reticulumMethylationPlasma membraneAutophosphorylationAcetylationEnzyme complexGlycosylationSumoylationMolecular associationDeubiquitinationReceptorPhosphorylationMitochondrionAccession Number: NetPath 9; cellmap:9ECNucleusDeacetylationTranslocationMolecule in the pathwayDemethylationCY ->NUExtracellularDephosphorylationLOC796190T2BPLOC564279ube2imap3k3wu:fc75a03fkbp5IQGAP2TNFLOC100005446gab1psmc2cul1aAKAP8PEG3cyldUSP11ppp1r13lDPF2zgc:153048zgc:66260ripk3lpsmd7kpna3zfand5aGeneNALP4smarca4smarcb1aDDX3psmc3rpl6IKBKETNFRSF8POLR1ACASP8AP2rpl8PKN1txlnagsk3bHDAC2RELBRELFLNArelazgc:172137LOC564254psmb5hdac6relaPIAS3map3k3smarce1craddrpl30zgc:136449pbpfaddube2d2USP2map3k7ip3lcops3Genecasp8ikbkgzgc:158276nkiras1LOC564497zgc:55886LOC565656NFKBIAzgc:76869YWHAQLOC563727ktn1MAP3K14wu:fj98a08nfkb2trpc4apamap3k7ip1psmd12LOC100149852NFKB1pfdn2srctraf4aeif4a3psmd6PMLcasp2GTF2IrelachukPSMC1zgc:158370LOC792354si:dkey-220o5.3casp7ASE1HIST3H3LOC792188kpna2papolbSKP1Aptk2.1wu:fc75f05LOC571171MAP3K7IP2polr1cGenekcnq1dap1atraddTNFmcm5tnfrsf1asmarcc1ikbkbfblzgc:112305nr2c2SUMO1traf1ikbkgywhae1BCL7APSMD13LOC565173ripk2tbk1zgc:136584hdac1tnfrsf1arps13BIRC3LOC795364NFKBIANFKBIBnr2c2prkczGeneLOC100005446traf4aRELchukbirc2rps11traf1cdc37actl6atnip1zgc:56064zgc:162191TNFripk1lhsp90ab1traf6LOC796190pdcd2TNFNFKB1relaTRAF5LOC791511YWHABUNC5CLDBC1ikbkaplNFKBIALOC564899mcm7BIRC3NFKB1LOC100005446CDC34TNFcapn3lrpprcCASP3psmd1LOC556379LOC100150217casp8l2traddnfkbiztbk1akt2LOC559441LOC558321birc2LOC796190traf3tnfrsf1apsmd3YWHAZcflarcav1rpl4TNFFBXW11ptpn11faf1traipfancd2polr1eck2bBTRCrps6kb1crebbpbLOC100150926POLR1Bripk1lgnb2l1RELBLOC567476YWHAGGene Symbolstat1ahsp90a.2hspb1zgc:158799wdr68ywhah


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 71% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116912view11:49, 15 May 2021EweitzModified title
108316view20:34, 6 December 2019L DupuisConverted interactions to graphical lines in legend
108151view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87784view11:13, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87783view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68632view04:45, 6 July 2013MaintBotUpdated to 2013 gpml schema
40798view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34187view21:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32336view13:31, 15 August 2009MaintBotFixed text labels
31948view13:00, 14 August 2009MaintBotFixed group labels
31380view20:40, 13 August 2009MaintBotFixed text labels
31081view01:33, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKAP8GeneProduct
ASE1GeneProduct
BCL7AGeneProduct57952 (Entrez Gene)
BIRC3GeneProduct
BTRCGeneProduct
CASP3GeneProduct
CASP8AP2GeneProduct541521 (Entrez Gene)
CDC34GeneProduct
DBC1GeneProduct
DDX3GeneProduct566947 (Entrez Gene)
DPF2GeneProduct474324 (Entrez Gene)
FBXW11GeneProduct
FLNAGeneProduct562529 (Entrez Gene)
GTF2IGeneProduct
GeneGeneProduct
Gene SymbolGeneProduct
HDAC2GeneProduct
HIST3H3GeneProduct
IKBKEGeneProduct437024 (Entrez Gene)
IQGAP2GeneProduct
LOC100005446GeneProduct100005446 (Entrez Gene)
LOC100149852GeneProduct100149852 (Entrez Gene)
LOC100150217GeneProduct100150217 (Entrez Gene)
LOC100150926GeneProduct100150926 (Entrez Gene)
LOC556379GeneProduct556379 (Entrez Gene)
LOC558321GeneProduct558321 (Entrez Gene)
LOC559441GeneProduct559441 (Entrez Gene)
LOC563727GeneProduct563727 (Entrez Gene)
LOC564254GeneProduct564254 (Entrez Gene)
LOC564279GeneProduct564279 (Entrez Gene)
LOC564497GeneProduct564497 (Entrez Gene)
LOC564899GeneProduct564899 (Entrez Gene)
LOC565173GeneProduct565173 (Entrez Gene)
LOC565656GeneProduct565656 (Entrez Gene)
LOC567476GeneProduct567476 (Entrez Gene)
LOC571171GeneProduct571171 (Entrez Gene)
LOC791511GeneProduct791511 (Entrez Gene)
LOC792188GeneProduct792188 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
LOC795364GeneProduct795364 (Entrez Gene)
LOC796190GeneProduct796190 (Entrez Gene)
MAP3K14GeneProduct
MAP3K7IP2GeneProduct494163 (Entrez Gene)
NALP4GeneProduct
NFKB1GeneProduct565756 (Entrez Gene)
NFKBIAGeneProduct
NFKBIBGeneProduct
PEG3GeneProduct
PIAS3GeneProduct
PKN1GeneProduct
PMLGeneProduct
POLR1AGeneProduct327078 (Entrez Gene)
POLR1BGeneProduct
PSMC1GeneProduct
PSMD13GeneProduct393922 (Entrez Gene)
RELGeneProduct415101 (Entrez Gene)
RELBGeneProduct
SKP1AGeneProduct
SUMO1GeneProduct406438 (Entrez Gene)
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cyldGeneProduct556823 (Entrez Gene)
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lrpprcGeneProduct557195 (Entrez Gene)
map3k3GeneProduct560211 (Entrez Gene)
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mcm5GeneProduct286747 (Entrez Gene)
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nfkb2GeneProduct415100 (Entrez Gene)
nfkbizGeneProduct100001781 (Entrez Gene)
nkiras1GeneProduct100002175 (Entrez Gene)
nr2c2GeneProduct569321 (Entrez Gene)
papolbGeneProduct404041 (Entrez Gene)
pbpGeneProduct406627 (Entrez Gene)
pdcd2GeneProduct393370 (Entrez Gene)
pfdn2GeneProduct323012 (Entrez Gene)
polr1cGeneProduct393538 (Entrez Gene)
polr1eGeneProduct553733 (Entrez Gene)
ppp1r13lGeneProduct541507 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
psmb5GeneProduct30387 (Entrez Gene)
psmc2GeneProduct393941 (Entrez Gene)
psmc3GeneProduct321947 (Entrez Gene)
psmd12GeneProduct321898 (Entrez Gene)
psmd1GeneProduct554967 (Entrez Gene)
psmd3GeneProduct393544 (Entrez Gene)
psmd6GeneProduct393261 (Entrez Gene)
psmd7GeneProduct327330 (Entrez Gene)
ptk2.1GeneProduct142986 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
ripk1lGeneProduct567460 (Entrez Gene)
ripk2GeneProduct373874 (Entrez Gene)
ripk3lGeneProduct100004555 (Entrez Gene)
rpl30GeneProduct336713 (Entrez Gene)
rpl4GeneProduct337090 (Entrez Gene)
rpl6GeneProduct336727 (Entrez Gene)
rpl8GeneProduct393686 (Entrez Gene)
rps11GeneProduct406686 (Entrez Gene)
rps13GeneProduct415169 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
si:dkey-220o5.3GeneProduct100001980 (Entrez Gene)
smarca4GeneProduct353295 (Entrez Gene)
smarcb1aGeneProduct799716 (Entrez Gene)
smarcc1GeneProduct403020 (Entrez Gene)
smarce1GeneProduct322248 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
tbk1GeneProduct692289 (Entrez Gene)
tnfrsf1aGeneProduct406471 (Entrez Gene)
tnip1GeneProduct449958 (Entrez Gene)
traddGeneProduct58130 (Entrez Gene)
traf1GeneProduct100148503 (Entrez Gene)
traf3GeneProduct445119 (Entrez Gene)
traf4aGeneProduct404045 (Entrez Gene)
traf6GeneProduct554561 (Entrez Gene)
traipGeneProduct402900 (Entrez Gene)
trpc4apaGeneProduct58090 (Entrez Gene)
txlnaGeneProduct324180 (Entrez Gene)
ube2d2GeneProduct335444 (Entrez Gene)
ube2iGeneProduct30622 (Entrez Gene)
wdr68GeneProduct337565 (Entrez Gene)
wu:fc75a03GeneProduct793730 (Entrez Gene)
wu:fc75f05GeneProduct562231 (Entrez Gene)
wu:fj98a08GeneProduct792865 (Entrez Gene)
ywhae1GeneProduct322060 (Entrez Gene)
ywhahGeneProduct406443 (Entrez Gene)
zfand5aGeneProduct406312 (Entrez Gene)
zgc:112305GeneProduct553705 (Entrez Gene)
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zgc:136584GeneProduct692293 (Entrez Gene)
zgc:153048GeneProduct767660 (Entrez Gene)
zgc:158276GeneProduct790944 (Entrez Gene)
zgc:158370GeneProduct556409 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
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zgc:172137GeneProduct100007679 (Entrez Gene)
zgc:55886GeneProduct393934 (Entrez Gene)
zgc:56064GeneProduct393885 (Entrez Gene)
zgc:66260GeneProduct100003846 (Entrez Gene)
zgc:76869GeneProduct406377 (Entrez Gene)

Annotated Interactions

No annotated interactions
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