PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens)

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1PI3K inhibitorsAllosteric mTOR inhibitorsATP site mTOR inhibitorsAKT inhibitorsTFEBMTORRICTORPDK1p27BAD4EBP1FOXO1TSC2PIP3eNOSMTORS6K1GSK3BFOXO4RTKRHEBGRB10ATG13ULK1PTENAKTRasPIP2FIP200PI3KGPCRFOXO3RAPTOR


Description

This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell’s ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success.

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Ontology Terms

 

Bibliography

  1. Merritt P Edlind, Andrew C Hsieh; ''PI3K-AKT-mTOR singaling in prostate cancer progression and androgen deprivation therapy resistance''; NIH, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129541view15:51, 10 May 2024EweitzModified title
129324view13:58, 26 March 2024MkutmonOntology Term : 'prostate cancer' added !
129323view13:58, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129322view13:58, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
127077view00:25, 28 July 2023Khanspersupdated mTORC1 and mTORC2 complexes
107714view08:20, 31 October 2019DeSlReverted to version '13:23, 17 September 2019' by DeSl
107700view11:37, 29 October 2019LilingModified description
106751view13:23, 17 September 2019MaintBotHMDB identifier normalization
106550view00:12, 6 September 2019KhanspersModified description
105495view05:49, 8 August 2019KhanspersModified description
89952view14:17, 6 October 2016MkutmonModified description
89754view18:10, 30 September 2016Khanspersupdated some interactions
89740view23:39, 29 September 2016KhanspersModified title
88432view20:17, 6 August 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88431view20:14, 6 August 2016AlexanderPicoUpdated complex, metabolites and interactions
88430view19:34, 6 August 2016AlexanderPicoUpdated PMID
88369view21:15, 1 August 2016AAR&CoModified description
88367view21:13, 1 August 2016AAR&CoBolded Labels
88325view15:44, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
88323view15:43, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
88213view17:36, 31 July 2016AAR&CoModify Datanode
88206view13:59, 31 July 2016AAR&CoPeriodical save, work in progress
88205view13:46, 31 July 2016AAR&CoModify Datanode
88200view12:55, 31 July 2016AAR&CoModify Datanode
88195view12:34, 31 July 2016AAR&CoClose excess space
87101view17:17, 18 July 2016AAR&CoFixed Unconnected Lines
86821view23:23, 11 July 2016AAR&CoModified description
86820view23:22, 11 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4EBP1 GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
FOXO4GeneProductENSG00000184481 (Ensembl)
GPCRGeneProductQ5T6X5 (Uniprot-TrEMBL)
GRB10GeneProductENSG00000106070 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteHMDB10035 (HMDB)
PIP3MetaboliteHMDB10147 (HMDB)
PTENGeneProductENSG00000171862 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RTKGeneProductP08922 (Uniprot-TrEMBL) Receptor tyrosine kinases
RasGeneProductENSG00000228903 (Ensembl)
S6K1GeneProductENSG00000082701 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
eNOSGeneProductENSG00000164867 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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