VEGFA-VEGFR2 signaling (Homo sapiens)

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95STAT3PROCK2PRKD2373795MAPK3Y204T202MAPK1Y187T1853262, 137MAPK1Y187T18594129, 243911151, 102, 16421417532, 90MAP2K3MAP2K6P2721MAPK9MAPK8Y185T183STAT3PMAPK3T183146MAPK3Y204T20214829, 49, 111, 183MAPK1Y18522PRKCZ80, 211PIK3R2ACACBNCF2MAPK12RAP1B133VEGFR2MeK1041Y1175Y1214Y1054Y951Y996Y10599992, 243197AP1complexSoluble andcleaved FLT1may sequesterVEGFA fromVEGFR2PKC delta/ZetadependentEpoxyeicosatrienoicacid regioisomersEC proliferation,migration,tube formationand angiogenesisCYCell motilityand tube formationEC Migration andTube Formation133, 154157FADDTCEB3FAF1FASBIN1BMXHDAC1TNFRSF10CHSPA1ASMARCA2226DOK1PGAB1PReceptorPROTEINLigandProtein translocation LEGENDMultiple colored edges are introduced to distinguish the connecting nodesPhosphorylated form with/without site & residueEndosomeNucleusMitochondrionCytoplasmPlasma membraneMTEndoplasmic reticulumCYPMNUERENVEGFR2Y1059Y1175Y801Y951Y1054Y1214127VEGFA252MAPK14P114, 225225F-actinreorganization20, 225225Stress fibreformationFocal adhesionassembly andcell migration225NCK1PFYNPPAK2P133STAT1PSTAT6P48, 134STAT1PSTAT6P134NUFRS2PCRKPPRKCI79797979133SRCY419Y530113130RAPGEF1148148RAP1AGTP148ITGAVITGB3Y773148BCAR1P127, 193PLCG1Y783Ub231SHC1193SHC219322, 133PTK2Y861S732Y407Y576Y397237IQGAP1PRAC1GTP100, 142197197Directed Cell migration73, 197, 202ITGB5ITGB1ITGAV16145, 161161161235SH2D2A174174207VascularpermeabilityNAADP152TPCN2Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+152152H+H+H+ATPADP152152152Endolysosomalcalcium storeMAPKAPK2T334114, 234114114114PLAUPIP2IP3DAG333333CAPN2105Ca2+Ca2+Ca2+187MYL9S20T19237Endothelial cellcontraction athigh VEGFA levels237156ROCK1P156, 228RHOAGTP107, 118, 156, 228, 229100RHOCGTP146, 239Endothelial cellProliferationand migration146146MAP2K1S218S22292, 14614624, 113CBL242424ITPR133146PRKCBPRKCAS657223RAF1P102, 214, 223SPHK1PHRAS78GTP3361PRKD1S910S742S738946194, 157HDAC5S259S49894HDAC5S498S259PRKCDPRKCEPLA2G4AP10251, 102PGI2HSPB1S78S15S8255109NRP1247CAV1Y14130130130CDH5215PTPN11215CSK215215215204PTK2BY40224076, 80HSP90AA113913976, 13952MLLT4168168FHL220020059PLCB3S1105S537128128CDC42GTP128WASF1NCF1PPAK1P200195195PTPN968PTPRZ167676767NCLMYH9NCL13113113113150AKT1T308S47350FOXO1S256AKT1S473T30850, 86, 23050FOXO1S25627, 505050, 215, 224RELANFKBIA36P12612618, 57, 112, 126126PLA2G5RPS6KA5P474747145, 203PIK3R1P143145, 230NOS3S114S117923155, 105, 145NO145LIMK1S323CFL1S355202020, 109VAV2Y172118118FLNB9191, 22091PFN1Y1297777G-actin bindingand actinpolymerization77At cellleadingedge11990, 138ATF2T71T69Promotes endothelial-leukocyte interactions909032Endothelialcell survival32, 218GRB2P113113139, 211PXNpY80, 93, 116170GJA1S255S279S368S262S282238ClathrinmediatedGap junctioninternalization111GJA1S368S262S279S282S255Stress fibreformation119PTPRJ192, 224192, 224224SHBP62626262144, 154144, 1541547676ROCK1P76RPS6KB1T4121TXNIPACP1S-glutathionylation1, 40TXN11, 40ONOO-1150, 125Cysteineoxidationof VEGFR2and SRCPTPN6181181GRB10P21013, 195PRKAA1T183ROSMitochondrial20213CytosolicROS132Angiogenesis13284, 13212, 38, 101cGMP38, 82Angiogenesis12, 38, 101CREB1P98CAMKK215, 84ACACAP84, 21315, 84PRKAA2202ARHGEF15167167RHOJ54GTP167167137SHC1S36137PDPK1S241243PIP2PIP3R1CTORMLST8MAPKAP1MTORS2448S24816969MTORRAPTORMLST8243243Non-phosphoform of SHC243NRDG1T345mTORC2mTORC1217117, 218GSK3BS9230166, 243243AKT1S1T266129129129RPS6S236S235129, 166203RAPTORMTORMLST8mTORC1166ER stress-independentVEGF-UPR machinerymediated pathwayEIF2AK3ERN1PATF6EIF2AS51166166166GeneexpressionATF4166166DNAJB9HERPUD1166AKT1S473166133119CAPN2187EZR105105105TRPC1ITPR1191KL121121Ca2+Ca2+Ca2+Ca2+Ca2+121191Calciumreleasefrom ERPIK3CA168TXNIPVEGFR21PLCG1Y783RAB5ACDH5S665CTNND1S268S252CTNNB1CTNNA1S453MAP2K1S218S222MAP2K2185185VEGFR2Y1175Y1214Ub10Lysosomemediatedpartialproteosomaldegradation230 kDa160 kDaFBXW1110EEA144SLC8A1Ca2+Ca2+Ca2+Ca2+28Na+Na+28282828Mostlyclathrindependentinternalization4HGSY334VEGFR2Y1214Y1175UbSTAM7070GIPC1MYO6163PTPN1135, 1632407NRP177ClathrindependentinternalizationNRP1RAB11VEGFR2NRP183VEGFR2recycling83177SRCY527Y416VAV2Y172RAC1100, 142GTPPAK2PARRB2118, 177177100, 118, 177177177177177177CDH5S655CTNND1CTNNB1ARRB2177177177VE CadherinrecyclingEarly endosomes122122122122Regulation ofcell survivalRegulation ofchromatinremodellingRNA elongationby RNA Pol II122122122VCLS34613913976, 13976, 139139103Regulation ofendothelial cellsproutingCLTC10Involvedin the activationof VEGFR2162MAPKAPK5T182162162NRP2MAP3K5S83MAP2K7PMAP2K4T261JUNS63212121AKT1T308S473CAV1Y14130ARF6108ARF6108ANXA1P190190172NFATC2dePNFATC2deP3, 65, 221, 2313NFATC1NFATC125, 30PTGS2231EC Migration19RND119179, 208, 221EGR15, 25, 1155, 25, 115SRF5, 25, 115NUR4A2NUR4A325PPP3CACREB1P9851, 1023, 65, 179, 208, 221...Ca2+Ca2+Ca2+JAG1DKK1CCL2CXCL8AMOTBMP10179TEAD441, 5311, 158, 179416523PKC delta/betadependentTEAD44123104EndosomeRegulation of receptor endocytosis and recyclingCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNUNUCYNFKB1RELANFKB1ICAM1SELE112Promotes endothelial-leukocyte interactions11218Endothelialcell survival4848FOXO4S197FOXO327FOXO4FOXO32727CYNUCYNU27Decreasedexpressionby nuclearexport ofFOXO1/3/4Endothelialcell survival27VEGFR2EndosomeRAB4A44RAB4A44ENPMHGSEPS15EPN1OCLNS490UbITCHGap junctiondisruptionNa+Na+7575, 216, 2197575Tight junctiondisruption75Occludininternalizationand proteosomaldegradationHDAC7S397S194S479FLNBK1147220220YWHAE194HDAC7S194S397S479HDAC9S254S245HDAC4S467S 246CY63, 194, 220NUMEF2CCCND114663, 194, 22023, 63, 194, 220RCAN2MMP10MMP14Activationof MEF2 by nuclearexport ofHDACsEC proliferation,migration,tube formationand angiogenesis63, 194, 22023MKNK1PMKNK1P214NUCYEIF4EP214ELK1153OCLNUbS49049, 75PMENITGAVStimulationof tip cellfilopodiaPLAURPLAU120PLAUProActiveMMP2747426, 71, 120ITGAVITGB1PLAURPLAUCell migrationand invasion120PMENClathrinmediatedF3233NUR4A1VCAM1BCL2L1CYP2C8SOD2ADAMTS1ACKR3EGR3233HBEGFRCAN1CDKN1BNUR4A1MEF2C233VCAM1233CCL2BCL2CTNNB1VEGFA SIGNALING PATHWAY IN ENDOTHELIAL CELLSCTNNB1Y142999, 141Adherensjunctiondisassembly9ATF2T69T71BCL2L132ERG95NOTCH4DLL4130ETS1149AA51, 102, 164164PTGS2S-nitrosylPTGS214NOS314T172PRKG18238, 82ProteinComplexSmallmoleculesTranscriptional regulation of gene expression (multiple colours)Unique solid edges between receptor and other proteinsDirect protein-protein interactions associated with VEGFR2 phospho-Y1175Direct protein-protein interactions associated with VEGFR2 phospho-Y801Direct protein-protein interactions associated with VEGFR2 phospho-Y1214Direct protein-protein interactions associated with VEGFR2 phospho-Y951Direct protein interactions of VEGFR2 for which a specific VEGFR2 phosphosite involvement isnot reported AND also represents direct protein-protein interactions between other proteinsDirect phosphorylations by VEGFR2 AND also represents otherdirect kinase-substrate phosphorylation eventsGeneric edges between proteinsSolid edges Dashed edgesDirect protein-protein interactions or enzyme-substrate reactionsLeads to, through unknown or not reported intermediatesDirect dephosphorylation of substrates by phosphatasesDirect ubiquitination of substrates by E3 ubiquitin ligasesDirect protein cleavage of substrates by proteasesDirect inhibition of protein activityDissociation of direct protein-protein interactionsLeads to, through unknown ornot reported/studied intermediatesUbiquitinated form with/without site & residueMethylated form with/without site & residueGlutathionilated form with/without site & residuePTMsProtein transport across multiple cell compartmentsPIP2 PtdIns(4,5)P2PIP3 PtdIns(3,4,5)P3DAG DiacylglycerolIP3 Inositol triphosphateROS Reactive oxygen speciesONOO- PeroxynitriteNAADP Nicotinic acid adenine dinucleotide phosphateATP Adenosine triphosphateGTP Guanosine triphosphateADP Adenosine diphosphateNO Nitric OxidecGMP Cyclic GMPAA Arachidonic AcidPGI2 Prostaglandin I2S-nitrosilated formPROTEINmRNASmallmoleculesmRNAPROTEINModifiedformIncreasedexpressionDecreasedexpressionPI3K-AKT-MTOR ModuleP38 MAPKModuleJNKModulePLC-PKCModuleERKModuleNFKBModuleFAKModuleRACModuleSTATModuleRHOAModuleADAMTS188VEGFA-165aFGAMMRN2TNXBIGFBP7GPC1CTGF1552411368920681PGF8FGBFGGVEGFA-145aVEGFA-145bVEGFA-111VEGFA-148VEGFA-165aVEGFA-165bVEGFA-121aVEGFA-121bVEGFA-183aVEGFA-183bVEGFA-162VEGFA-206VEGFA-189aVEGFA-189bMultiple VEGFA isoforms196196FLT1Y794Y1213Y1333Y1169244, 245249249249249246, 251248RACK1250250Direct protein-protein interactions associated with FLT1 phospho -Y794, -Y1169, -Y1213 & -Y1333VEGFAVEGFA-165a252242


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  215. Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE; ''Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.''; Am J Physiol Cell Physiol, 2011 PubMed Europe PMC Scholia
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  217. Reihill JA, Ewart MA, Hardie DG, Salt IP; ''AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  218. Kroll J, Waltenberger J; ''The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  219. Zhao ZS, Manser E; ''''; , PubMed Europe PMC Scholia
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  221. Tahir SA, Park S, Thompson TC; ''Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.''; Cancer Biol Ther, 2009 PubMed Europe PMC Scholia
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  223. Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, Gaumann A, Breier G, Drexler HC, Suttorp N, Clauss M; ''p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.''; FASEB J, 2003 PubMed Europe PMC Scholia
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  226. Lal BK, Varma S, Pappas PJ, Hobson RW 2nd, Durán WN; ''VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways.''; Microvasc Res, 2001 PubMed Europe PMC Scholia
  227. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N; ''Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
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  229. Zeng H, Zhao D, Mukhopadhyay D; ''KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  230. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD; ''VEGF-induced vascular permeability is mediated by FAK.''; Dev Cell, 2012 PubMed Europe PMC Scholia
  231. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J; ''Rheb binds and regulates the mTOR kinase.''; Curr Biol, 2005 PubMed Europe PMC Scholia
  232. Andrikopoulos P, Baba A, Matsuda T, Djamgoz MB, Yaqoob MM, Eccles SA; ''Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  233. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T, Ushio-Fukai M; ''Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.''; PLoS One, 2010 PubMed Europe PMC Scholia
  234. Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S; ''VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.''; Mol Biol Cell, 2014 PubMed Europe PMC Scholia
  235. Dance M, Montagner A, Yart A, Masri B, Audigier Y, Perret B, Salles JP, Raynal P; ''The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  236. Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M; ''VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.''; Dev Cell, 2010 PubMed Europe PMC Scholia
  237. Jang GH, Park IS, Yang JH, Bischoff J, Lee YM; ''Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  238. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA; ''Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
  239. Gavard J, Gutkind JS; ''VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.''; Nat Cell Biol, 2006 PubMed Europe PMC Scholia
  240. Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR; ''Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.''; Blood, 2004 PubMed Europe PMC Scholia
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  244. Rao A, Luo C, Hogan PG; ''''; , PubMed Europe PMC Scholia
  245. Neagoe PE, Lemieux C, Sirois MG; ''Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  246. Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziche M; ''Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium.''; Am J Physiol, 1996 PubMed Europe PMC Scholia
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  253. Combs MD, Yutzey KE; ''VEGF and RANKL regulation of NFATc1 in heart valve development.''; Circ Res, 2009 PubMed Europe PMC Scholia
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History

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126337view06:12, 22 April 2023EgonwLicense is CCZero
124848view21:27, 14 December 2022EweitzModified title
116782view09:53, 14 May 2021EweitzModified title
115530view10:00, 26 February 2021DeSlAdded database name for BMX
108912view12:37, 6 February 2020PrslabModified description
108911view12:20, 6 February 2020PrslabModified description
108910view12:19, 6 February 2020PrslabModified description
108909view08:00, 6 February 2020PrslabModified description
108905view06:18, 6 February 2020PrslabModified description
108904view06:17, 6 February 2020PrslabModified description
108903view05:57, 6 February 2020PrslabModified description
108902view05:57, 6 February 2020PrslabModified description
108901view05:56, 6 February 2020PrslabModified description
108900view05:55, 6 February 2020PrslabModified description
108899view05:54, 6 February 2020PrslabModified description
108895view03:24, 5 February 2020PrslabModified description
108894view03:21, 5 February 2020PrslabModified description
108893view03:18, 5 February 2020PrslabModified description
108892view03:17, 5 February 2020PrslabModified description
108891view03:15, 5 February 2020PrslabModified description
108890view03:14, 5 February 2020PrslabModified description
108889view03:13, 5 February 2020PrslabModified description
108888view03:12, 5 February 2020PrslabModified description
108796view07:05, 30 January 2020PrslabModified description
108795view06:38, 30 January 2020PrslabModified title
108463view11:59, 21 December 2019PrslabModified description
108462view11:57, 21 December 2019PrslabModified description
108339view06:06, 9 December 2019EgonwReplaced a weblink by its PubMed identifier.
108332view10:56, 7 December 2019EgonwModified title
108313view06:05, 5 December 2019PrslabModified title
108312view01:06, 5 December 2019MaintBotupdated with GPML provided by author
108252view07:20, 3 December 2019PrslabModified title
108251view07:13, 3 December 2019PrslabModified title
108249view06:59, 3 December 2019Prslab2019 Update version of VEGFA-VEGFR2
106441view23:30, 28 August 2019KhanspersModified description
105478view05:24, 8 August 2019KhanspersModified description
102004view15:48, 23 November 2018EgonwMoved a non-pubmed ID to a comment.
90000view09:56, 7 October 2016PrslabModified description
89999view09:54, 7 October 2016PrslabModified description
89998view09:27, 7 October 2016PrslabModified description
89997view09:18, 7 October 2016PrslabModified description
89996view09:17, 7 October 2016PrslabModified description
89396view19:22, 10 September 2016AlexanderPicoModified title
89247view16:06, 25 August 2016KhanspersOntology Term : 'endothelial cell' added !
89246view16:01, 25 August 2016KhanspersReverted to version '06:50, 25 August 2016' by Khanspers
89245view15:55, 25 August 2016Khansperstest
89242view06:50, 25 August 2016PrslabOntology Term : 'vascular endothelial growth factor signaling pathway' added !
89241view06:38, 25 August 2016PrslabModified title
89240view06:34, 25 August 2016PrslabNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAProtein31 (Entrez Gene)
ACACBProtein32 (Entrez Gene)
ACKR3Protein57007 (Entrez Gene)
ACP1Protein52 (Entrez Gene)
ADAMTS1Protein9510 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
AKT1S1Protein84335 (Entrez Gene)
AMOTProtein154796 (Entrez Gene)
ANXA1Protein301 (Entrez Gene)
ARF6Protein382 (Entrez Gene)
ARHGEF15Protein22899 (Entrez Gene)
ARRB2Protein409 (Entrez Gene)
ATF2Protein1386 (Entrez Gene)
ATF4Protein468 (Entrez Gene)
ATF6Protein22926 (Entrez Gene)
BCAR1Protein9564 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
BCL2L1Protein598 (Entrez Gene)
BIN1Protein274 (Entrez Gene)
BMP10Protein27302 (Entrez Gene)
BMXProtein660
CAMKK2Protein10645 (Entrez Gene)
CAPN2Protein824 (Entrez Gene)
CAV1 Protein857 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CCL2Protein6347 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CDH5Protein1003 (Entrez Gene)
CDKN1BProtein8013 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
CLTCProtein1213 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CRKProtein1398 (Entrez Gene)
CSKProtein1445 (Entrez Gene)
CTGFProtein1490 (Entrez Gene)
CTNNA1Protein1495 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
CTNND1Protein1500 (Entrez Gene)
CXCL8Protein3576 (Entrez Gene)
CYP2C8 Protein1558 (Entrez Gene)
DKK1Protein22943 (Entrez Gene)
DLL4Protein54567 (Entrez Gene)
DNAJB9Protein4189 (Entrez Gene)
DOK1 Protein1796 (Entrez Gene)
EEA1Protein8411 (Entrez Gene)
EGR1Protein1958 (Entrez Gene)
EGR3Protein1960 (Entrez Gene)
EIF2AProtein83939 (Entrez Gene)
EIF2AK3Protein9451 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
EPN1Protein29924 (Entrez Gene)
EPS15Protein2060 (Entrez Gene)
ERGProtein2078 (Entrez Gene)
ERN1Protein2081 (Entrez Gene)
ETS1Protein2113 (Entrez Gene)
EZRProtein7430 (Entrez Gene)
F3Protein2152 (Entrez Gene)
FADDProtein8772 (Entrez Gene)
FAF1Protein11124 (Entrez Gene)
FASProtein355 (Entrez Gene)
FBXW11Protein23291 (Entrez Gene)
FGAProtein2243 (Entrez Gene)
FGBProtein2244 (Entrez Gene)
FGGProtein2266 (Entrez Gene)
FHL2Protein2274 (Entrez Gene)
FLNBProtein2317 (Entrez Gene)
FLT1Protein2321 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FOXO3Protein2309 (Entrez Gene)
FOXO4Protein4303 (Entrez Gene)
FRS2Protein10818 (Entrez Gene)
FYN Protein2534 (Entrez Gene)
GAB1Protein2549 (Entrez Gene)
GIPC1Protein10755 (Entrez Gene)
GJA1Protein2697 (Entrez Gene)
GPC1Protein2817 (Entrez Gene)
GRB10Protein2887 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HBEGFProtein1839 (Entrez Gene)
HDAC1Protein3065 (Entrez Gene)
HDAC4Protein9759 (Entrez Gene)
HDAC5Protein10014 (Entrez Gene)
HDAC7Protein51564 (Entrez Gene)
HDAC9Protein9734 (Entrez Gene)
HERPUD1Protein9709 (Entrez Gene)
HGSProtein9146 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
HSP90AA1Protein3320 (Entrez Gene)
HSPA1AProtein3303 (Entrez Gene)
HSPB1Protein3315 (Entrez Gene)
ICAM1Protein3383 (Entrez Gene)
IGFBP7Protein3490 (Entrez Gene)
IQGAP1Protein8826 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
ITGAVProtein3685 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
ITGB3Protein3690 (Entrez Gene)
ITGB5Protein3693 (Entrez Gene)
ITPR1Protein3748 (Entrez Gene)
JAG1Protein182 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KLProtein9365 (Entrez Gene)
LIMK1Protein3984 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K4Protein6416 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAP2K7Protein5609 (Entrez Gene)
MAP3K5Protein4217 (Entrez Gene)
MAPK12Protein6300 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MAPKAP1Protein79109 (Entrez Gene)
MAPKAPK2Protein9261 (Entrez Gene)
MAPKAPK5Protein8550 (Entrez Gene)
MEF2CProtein4208 (Entrez Gene)
MKNK1Protein8569 (Entrez Gene)
MLLT4Protein4301 (Entrez Gene)
MLST8Protein64223 (Entrez Gene)
MMP10Protein4319 (Entrez Gene)
MMP14Protein4323 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMRN2Protein79812 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MYH9Protein4627 (Entrez Gene)
MYL9Protein4633 (Entrez Gene)
MYO6Protein4646 (Entrez Gene)
NCF1Protein653361 (Entrez Gene)
NCF2Protein4688 (Entrez Gene)
NCK1Protein4690 (Entrez Gene)
NCLProtein4691 (Entrez Gene)
NFATC1Protein4772 (Entrez Gene)
NFATC2Protein4773 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NOS3Protein4846 (Entrez Gene)
NOTCH4Protein4855 (Entrez Gene)
NRDG1Protein10397 (Entrez Gene)
NRP1Protein8821 (Entrez Gene)
NRP2Protein8828 (Entrez Gene)
NUR4A1Protein3164 (Entrez Gene)
NUR4A2Protein4929 (Entrez Gene)
NUR4A3Protein8013 (Entrez Gene)
OCLNProtein100506658 (Entrez Gene)
PAK1Protein5058 (Entrez Gene)
PAK2Protein5062 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PFN1Protein5216 (Entrez Gene)
PGFProtein5228 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLA2G4AProtein5321 (Entrez Gene)
PLA2G5Protein5322 (Entrez Gene)
PLAUProtein5328 (Entrez Gene)
PLAURProtein5329 (Entrez Gene)
PLCB3Protein5331 (Entrez Gene)
PLCG1Protein5335 (Entrez Gene)
PPP3CAProtein5530 (Entrez Gene)
PRKAA1Protein5562 (Entrez Gene)
PRKAA2Protein5563 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCIProtein5584 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PRKD1Protein5587 (Entrez Gene)
PRKD2Protein25865 (Entrez Gene)
PRKG1Protein5592 (Entrez Gene)
PTGS2Protein5743 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPN1Protein5770 (Entrez Gene)
PTPN6Protein5777 (Entrez Gene)
PTPN9Protein5780 (Entrez Gene)
PTPRJProtein5795 (Entrez Gene)
PTPRZ1Protein5803 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
R1CTOR Protein253260 (Entrez Gene)
RAB11Protein8766 (Entrez Gene)
RAB4AProtein5867 (Entrez Gene)
RAB5AProtein5868 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RAP1BProtein5908 (Entrez Gene)
RAPGEF1Protein2889 (Entrez Gene)
RAPTORProtein253260 (Entrez Gene)
RCAN1Protein1827 (Entrez Gene)
RCAN2Protein10231 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOAProtein387 (Entrez Gene)
RHOCProtein389 (Entrez Gene)
RHOJProtein57381 (Entrez Gene)
RND1Protein27289 (Entrez Gene)
ROCK1Protein6093 (Entrez Gene)
ROCK2Protein9475 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SELEProtein6401 (Entrez Gene)
SH2D2AProtein9047 (Entrez Gene)
SHBProtein6461 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SHC2Protein25759 (Entrez Gene)
SLC8A1Protein6546 (Entrez Gene)
SMARCA2Protein6595 (Entrez Gene)
SOD2Protein6648 (Entrez Gene)
SPHK1Protein55872 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
SRFProtein6722 (Entrez Gene)
STAMProtein8027 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
TCEB3Protein6924 (Entrez Gene)
TEAD4Protein7004 (Entrez Gene)
TNFRSF10CProtein8794 (Entrez Gene)
TNXBProtein7148 (Entrez Gene)
TPCN2Protein219931 (Entrez Gene)
TRPC1Protein7220 (Entrez Gene)
TXNProtein7295 (Entrez Gene)
TXNIPProtein10628 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VCAM1Protein5328 (Entrez Gene)
VCLProtein7414 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VEGFR2Protein3791 (Entrez Gene)
WASF1Protein8936 (Entrez Gene)
YWHAEProtein7531 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3888"
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