DNA replication (Danio rerio)

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1, 2UbiquitinOrc2Mcm4Orc complexOrc5a3. DNA replication initiationATPRFC140Orc complexCdc6PrimasePre-replicative complexRFC Heteropentamer:RNA primer-DNA primerdGTPRFC37Ubiquitinated Orc1p70Orc4Orc3p58Phosphorylated Orc1Pre-replicative complexGemininDegraded by proteasome in cytosoldCTPMcm5Cdt1RNA primer-DNA primer:origin duplex:PCNACdc6dUTP5. Leading/lagging strand synthesisADPCdt1Mcm7p180Orc3Orc2UTPCdc6ADPMcm10Mcm3GTPDNA polymerase alpha: primase: origin complexOrc3dATPOrc31. Assembly of the pre-replicative complexOrc4Mcm72. Activation of the pre-replicative complexPCNA homotrimerOrc complexMcm6RFC40Orc1Mcm2Orc2Degraded by proteasome in cytosolCdt1Cdt1RNA PrimerMcm3Phosphorylated Cdc6RFC38ATPRFC Heteropentamer:RNA primer-DNA primer:RNA primer-DNA primerp49RNA primer-DNA primerATPCdc6Processive complexRFC36Orc2Orc5DNA PolymeraseDNA polymerase alpha: primase: origin complexOriginOrc5Phosphorylation of Mcm 2-7 complexATPMcm 4,6,7 trimer forms and associatesMcm2Orc complexMcm64. Switching of origins to post-replicative stateCTPUbiquitinated Cdc6Mcm5Orc Complexwith the replication forkCdt1UbiquitinMcm4CDT1POLD4rfc4MCM10zgc:56598POLA1RPA4zgc:77827zgc:101602mcm4mcm5ORC2rfc5zgc:110727mcm3orc3lMCM7zgc:56264mcm2gmnnpcnaUBA52orc6zgc:85772POLE2zgc:110810POLD3CDC6UBCprim1rpa2MCM6zgc:77841POLD1zgc:56310rpa1rfc3orc1RFC1POLEASKpold2POLA2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC6GeneProductENSDARG00000009942 (Ensembl)
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2GeneProductENSDARG00000101465 (Ensembl)
POLA1GeneProductENSDARG00000045308 (Ensembl)
POLA2GeneProductENSDARG00000015070 (Ensembl)
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProductENSDARG00000076169 (Ensembl)
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProductENSDARG00000054799 (Ensembl)
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProductENSDARG00000102632 (Ensembl)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1GeneProductENSDARG00000039217 (Ensembl)
orc3lGeneProduct334315 (Entrez Gene)
orc6GeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProductENSDARG00000095046 (Ensembl)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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