Trehalose anabolism (Saccharomyces cerevisiae)

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1UDPUTPalpha,alpha-trehalose 6-phosphateH2OUDP-D-glucosetrehaloseTPS3glucose-1-phosphateTPS2pyrophosphateUGP1phosphatebeta-D-GlucoseglycolysisPGM2glucose-6-phosphateYHL012WTSL1TPS1PGM1H2OATH1NTH1


Description

Trehalose is a storage carbohydrate that can either be synthesized or obtained from the external environment. To be utilized as a carbon source, trehalase (EC:3.2.1.28) must convert trehalose and water into two molecules of glucose. S. cerevisiae has two trehalase enzymes, one is an acid trehalase encoded by ATH1 and the other is a neutral trehalase encoded by NTH1. The name "acid" or "neutral" are based on the optimal pH of each enzyme (pH 4.5-5.0 and pH 6.8-7.0, respectively).

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Quality Tags

Ontology Terms

 

Bibliography

  1. François J, Parrou JL; ''Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae.''; FEMS Microbiol Rev, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117351view11:54, 20 May 2021EweitzModified title
107258view14:35, 17 September 2019MaintBotChEBI identifier normalization
96414view11:59, 13 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94161view14:30, 24 August 2017DeSlAdded missing IDs to datanodes
94160view14:26, 24 August 2017DeSlModified description
94159view14:25, 24 August 2017DeSlChanged text labels into metabolite ndoes, annotated them, added lit. ref, connected all lines, added trehalose degradation to D-glucose.
69664view20:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
68410view16:38, 5 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
68409view13:59, 5 July 2013DdiglesOntology Term : 'trehalose biosynthetic pathway' added !
68408view13:58, 5 July 2013DdiglesOntology Term : 'PW:0000101' removed !
67714view11:53, 26 June 2013DdiglesOntology Term : 'translation pathway' added !
41905view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
21520view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Trehalose Anabolism]] moved to [[Pathway:WP398]]: Moved to stable identifier
12873view08:06, 17 May 2008MaintBotautomated metabolite conversion
8969view14:13, 7 January 2008MaintBotAdded to category $category
8967view14:13, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATH1GeneProductYPR026W (Ensembl) acid trehalase
H2OMetabolite
NTH1GeneProductYDR001C (Ensembl) neutral trehalase
PGM1GeneProductS000001610 (SGD)
PGM2GeneProductS000004711 (SGD)
TPS1GeneProductS000000330 (SGD)
TPS2GeneProductS000002481 (SGD)
TPS3GeneProductS000004874 (SGD)
TSL1GeneProductS000004566 (SGD)
UDPMetabolite
UDP-D-glucoseMetabolite
UGP1GeneProductS000001518 (SGD)
UTPMetabolite
YHL012WGeneProductS000001004 (SGD)
alpha,alpha-trehalose 6-phosphateMetabolite
beta-D-GlucoseMetaboliteCHEBI:10397 (ChEBI)
glucose-1-phosphateMetabolite59-56-3 (CAS)
glucose-6-phosphateMetabolite59-56-3 (CAS)
glycolysisPathway
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
trehaloseMetabolite99-20-7 (CAS)

Annotated Interactions

No annotated interactions
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