Thick ascending limb transporters (Rattus norvegicus)

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1-67Luminal sideATP1A1NaROMK 2/3NBCn1NHE3NKCC2K2 ClKK2 K2 K3 Na3 NaNaNaHHCO2H2OHHCO3HCO3NaHCO3NaClClBarttinBasolateral sideNaK2 ClKCC4KKClClAquaporin 1H2OH2OCLC-K2CA2CA4CO2H2OHHCO3ATPADPATP1B1K ChannelsKKKCNK12KCNQ1KCNK13KCNJ13KCNJ16Fxyd2CLC-K1NHE2


Description

This pathway shows the main transporters in the thick ascending limb of the Loop of Henle

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Cabral PD, Herrera M; ''Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb.''; Am J Physiol Renal Physiol, 2012 PubMed Europe PMC Scholia
  2. Hebert SC, Andreoli TE; ''Control of NaCl transport in the thick ascending limb.''; Am J Physiol, 1984 PubMed Europe PMC Scholia
  3. Greger R; ''Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron.''; Physiol Rev, 1985 PubMed Europe PMC Scholia
  4. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed Europe PMC Scholia
  5. Hamilton KL, Devor DC; ''Basolateral membrane K+ channels in renal epithelial cells.''; Am J Physiol Renal Physiol, 2012 PubMed Europe PMC Scholia
  6. Mount DB; ''Thick ascending limb of the loop of Henle.''; Clin J Am Soc Nephrol, 2014 PubMed Europe PMC Scholia
  7. Féraille E, Doucet A; ''Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control.''; Physiol Rev, 2001 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139749view04:19, 3 July 2025EgonwMore unicode
117017view11:36, 16 May 2021EweitzModified title
115291view11:12, 10 February 2021DeSlOntology Term : 'PW:0000103' removed !
106985view13:44, 17 September 2019MaintBotHMDB identifier normalization
95062view13:12, 11 November 2017EgonwFixed character encoding.
94968view13:48, 20 October 2017AgustinGVAdd refs
94967view13:40, 20 October 2017AgustinGVAdd NHE2
94966view13:39, 20 October 2017AgustinGVAdd Clcnka
94965view13:31, 20 October 2017AgustinGVAdd gamma subunit to NKA
94964view13:22, 20 October 2017AgustinGVUpdate Basolateral K channels
94669view13:37, 4 October 2017AgustinGVOntology Term : 'Bartter disease' added !
91330view18:17, 2 February 2017Khanspersconnected interactions
89594view15:56, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89125view19:21, 22 August 2016KhanspersModified title
89122view19:17, 22 August 2016KhanspersReverted to version '19:22, 18 August 2016' by Khanspers
89121view19:17, 22 August 2016KhanspersModified title
89037view19:22, 18 August 2016AlexanderPicoConverted interactions to graphical lines to avoid constraints and validation triggers
89036view19:13, 18 August 2016AgustinGVRefs.
89032view19:03, 18 August 2016MaintBotOntology Term : 'regulatory pathway' added !
89031view19:03, 18 August 2016MaintBotOntology Term : 'transport pathway' added !
89030view19:00, 18 August 2016AgustinGVSpecify description
89029view18:59, 18 August 2016AgustinGVSpecify description
89027view18:48, 18 August 2016AgustinGV
89026view18:40, 18 August 2016AgustinGV
89025view18:35, 18 August 2016AgustinGVUpdate CAs
89024view18:20, 18 August 2016AgustinGVModified description
89023view18:19, 18 August 2016AgustinGVOntology Term : 'transporting cell' added !
89022view18:17, 18 August 2016AgustinGVOntology Term : 'kidney epithelial cell' added !
89021view18:16, 18 August 2016AgustinGVMinor alignment
89020view18:14, 18 August 2016AgustinGVNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2 ClMetaboliteHMDB00492 (HMDB)
2 KMetaboliteHMDB00586 (HMDB)
3 NaMetaboliteHMDB00588 (HMDB)
ADPMetaboliteHMDB01341 (HMDB)
ATP1A1GeneProduct24211 (Entrez Gene)
ATP1B1GeneProduct25650 (Entrez Gene)
ATPMetaboliteHMDB00538 (HMDB)
Aquaporin 1GeneProduct25240 (Entrez Gene)
BarttinGeneProduct79430 (Entrez Gene)
CA2GeneProduct54231 (Entrez Gene)
CA4GeneProduct29242 (Entrez Gene)
CLC-K1GeneProduct79425 (Entrez Gene)
CLC-K2GeneProduct79430 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
ClMetaboliteHMDB00492 (HMDB)
Fxyd2GeneProduct29639 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
HCO3MetaboliteHMDB00595 (HMDB)
HMetaboliteHMDB59597 (HMDB)
K ChannelsGeneProduct
KCC4GeneProduct308069 (Entrez Gene)
KCNJ13GeneProduct94341 (Entrez Gene)
KCNJ16GeneProduct29719 (Entrez Gene)
KCNK12GeneProduct64119 (Entrez Gene)
KCNK13GeneProduct64120 (Entrez Gene)
KCNQ1GeneProduct84020 (Entrez Gene)
KMetaboliteHMDB00586 (HMDB)
NBCn1GeneProduct117955 (Entrez Gene)
NHE2GeneProduct24783 (Entrez Gene)
NHE3GeneProduct24784 (Entrez Gene)
NKCC2GeneProduct25065 (Entrez Gene)
NaMetaboliteHMDB00588 (HMDB)
ROMK 2/3GeneProduct24521 (Entrez Gene)

Annotated Interactions

No annotated interactions

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