Heterochronic gene regulation of development (Caenorhabditis elegans)

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1C.Elegant Larva StagesL1lin-4LIN-66LIN-14LIN-28mir-48mir-241mir-84DAF-12let-7LIN-46HBL-1L2L3L4ADULTLIN-41HBL-1LIN-29


Description

"The heterochronic gene pathway of Caenorhabditis elegans. The heterochronic pathway regulating larval development is shown. The arrows indicate activation; bars indicate repression. Regulatory relationships shown here are supported by genetic data, but not all are direct. lin-42 is not shown, as its complex expression pattern and genetic interactions suggest that it acts at multiple steps in the pathways, and its precise placement is uncertain. Note that in absence of ligand DAF-12 represses let-7 family miRNAs."

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Ontology Terms

 

Bibliography

  1. Resnick TD, McCulloch KA, Rougvie AE; ''miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans.''; Dev Dyn, 2010 PubMed Europe PMC Scholia
  2. Moss EG; ''Heterochronic genes and the nature of developmental time.''; Curr Biol, 2007 PubMed Europe PMC Scholia
  3. Abbott AL; ''Heterochronic genes.''; Curr Biol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135403view17:32, 3 September 2024EgonwConverted to use Ensembl identifiers
96861view23:39, 14 April 2018AlexanderPicoOntology Term : 'signaling pathway' added !
96860view23:39, 14 April 2018AlexanderPicoconnected one last line
96795view09:51, 9 April 2018DeSlConnected unconnected lines.
96775view17:02, 5 April 2018KhanspersModified description
96682view17:58, 26 March 2018Asios OliaAdded literature reference
96681view17:56, 26 March 2018Asios OliaModified description
96680view17:55, 26 March 2018Asios OliaModified description
96679view17:53, 26 March 2018Asios OliaModified description
96678view17:35, 26 March 2018Asios OliaAdded literature reference
96244view13:41, 2 March 2018FehrhartCorrected spelling error
96209view09:27, 28 February 2018Asios Olialarva to larval correction
96208view09:26, 28 February 2018Asios OliaDescriptor for L1 to L4 to adult elements
68466view20:27, 5 July 2013MaintBotUpdated to 2013 gpml schema
53146view02:10, 30 October 2012MaintBotModified categories
49514view01:27, 20 July 2012MaintBotOntology Term : 'signaling pathway pertinent to development' added !
49137view19:49, 6 July 2012KyookModified description
49136view19:48, 6 July 2012Kyookadd reference
49135view19:44, 6 July 2012KyookFigure 4 PMID:20232378
49134view19:37, 6 July 2012KyookPeriodical save, work in progress
49133view19:27, 6 July 2012KyookPeriodical save, work in progress
49132view19:17, 6 July 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DAF-12GeneProductF11A1.3 (WormBase)
HBL-1GeneProductF13D11.2 (WormBase)
LIN-14GeneProductT25C12.1 (WormBase)
LIN-28GeneProductF02E9.2 (WormBase)
LIN-29GeneProductW03C9.4 (WormBase)
LIN-41GeneProductC12C8.3 (WormBase)
LIN-46GeneProductR186.4 (WormBase)
LIN-66GeneProductB0513.1 (WormBase)
let-7RnaC05G5.6 (WormBase)
lin-4RnaF59G1.6 (WormBase)
mir-241RnaF56A12.4 (WormBase)
mir-48RnaF56A12.3 (WormBase)
mir-84RnaB0395.4 (WormBase)

Annotated Interactions

No annotated interactions

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