JAK/STAT pathway (Homo sapiens)

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AMPcAMPApoptosisCell CycleCyProtein-Protein InteractionActinCytoskeletonReorganizationProtein SynthesisCell GrowthRegulation ofFood IntakeNuRegulation ofCytoskeletonIL1RNELK1PRKAA1IRS2CREB1STAT3SOCS3MAPK3PIK3R2CyclinD1STAT1SH2B1SIRPAHRASMYCSTAT5AGRB2FOXO1MAPK1STAT3STAT3STAT1MAP2K2SHC-1NF-kBCISHPTK2FLNAEIF4ESTAT5AProteinRPS6KB1PIK3R1PTPN11MAP2K1PI3KGSK3BIRS1JUNYWHAZIGF-2PIK3R1GSK3AAGAP2ESR1RAF1STAT5BFYNCCND1IKBKBPIAS3KHDRBS1SOCS2STAT3AKT1PTPN1Enzyme ComplexRAC1NEK3p7056KRSP6PAK1NFKB1ZAP70JAK2PXNIRS1PTPN6PI3KPRLRBADPDE3BVAV2PRLCHUKIKKSTAT1IL1BBimMDM2EIF4EBP1CISHFOSNOS3PP1BIKBKGCBLPPIASOS1RPS6KA1GRB2MTORPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP1PPPPPGTPPPPPPPRELARELPp53FOXO3aCREBFKHRCREB1PSTAT1STAT3PPSTAT1STAT3PSTAT5ASTAT5APSTAT5ASTAT5BPSOCS3SOCS2IRF1NFKB1RELARELBAXBCL2L1PRLRGHPGHRGHRPIGF-1RLEPRLEPRLEPPLEPERRB2PEGFREGFRPEGFPIK3R2PIK3CAPPIK3CBPPIK3CGIRS2IRS1PPYWHAZSRCPSH2B1BADVAV1PTECITGB1STAT3PESR1ESR1ESR1CISHSTAT3STAT3PPIP3PDK1PIP2DAGPKCCa2+Ca2+SOC2SOC1IGF-1STAT1STAT1PSTAT1STAT1STAT1PSTAT1PPJAK1STAT3PPRKAA2PPACACAACACBPPCDC42RHOAROCK1ROCK2CFL2PRAC1MAPK8PMAPK14PMAPK8MAPK9PPPRLPP1BPRLPP1BNCOA1SP1TIMP1JAK1STAT1STAT3PIAS3COX2NOS3TWIST1STAT5BSTAT5APAURKAPIAS3LigandReceptormRNA


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ali S, Chen Z, Lebrun JJ, Vogel W, Kharitonenkov A, Kelly PA, Ullrich A; ''PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.''; EMBO J, 1996 PubMed Europe PMC Scholia
  2. Rawlings JS, Rosler KM, Harrison DA; ''The JAK/STAT signaling pathway.''; J Cell Sci, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124790view09:02, 11 December 2022EgonwThe identifier was an Entrez Gene identifier
117764view13:26, 22 May 2021EweitzModified title
97833view06:33, 10 June 2018EgonwAdded the reference mentioned in the description.
97832view06:31, 10 June 2018EgonwModified description
97784view14:03, 7 June 2018MaxvansonModified description
97783view14:01, 7 June 2018DeSlReverted to version '13:05, 7 June 2018' by DeSl
97752view13:12, 7 June 2018MaxvansonModified description
97742view13:05, 7 June 2018MaxvansonModified description
96782view16:04, 6 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96770view11:54, 5 April 2018Marvin M2Changed some lines into graphical lines
96769view11:48, 5 April 2018Marvin M2Annotated nodes, updated node types, updated legend into graphical elements
96251view14:25, 2 March 2018Fehrhartconnected some of the unconnected lines
86961view13:28, 15 July 2016MkutmonOntology Term : 'Jak-Stat signaling pathway' added !
74127view05:15, 1 April 2014EgonwFixed the Uniprot-TrEMBL data sources.
72588view04:14, 25 November 2013Prakamya1986New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProduct31 (Entrez Gene)
ACACBGeneProduct32 (Entrez Gene)
AGAP2GeneProduct
AKT1GeneProduct
AURKAGeneProduct6790 (Entrez Gene)
BADGeneProduct
BAXGeneProduct
BCL2L1GeneProduct
BimGeneProduct
CBLGeneProduct
CCND1GeneProduct
CDC42GeneProduct998 (Entrez Gene)
CFL2GeneProduct1073 (Entrez Gene)
CHUKGeneProduct
CISHGeneProduct
CISHGeneProduct1154 (Entrez Gene)
COX2GeneProduct4513 (Entrez Gene)
CREBGeneProduct
CREB1GeneProduct
Ca2+GeneProduct
CyclinD1GeneProduct
DAGGeneProduct
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct
EIF4EGeneProduct
EIF4EBP1GeneProduct
ELK1GeneProduct
ERRB2GeneProduct
ESR1GeneProduct2099 (Entrez Gene)
Enzyme ComplexGeneProduct
FKHRGeneProduct
FLNAGeneProduct
FOSGeneProduct
FOXO1GeneProduct
FOXO3aGeneProduct
FYNGeneProduct
GHGeneProduct
GHRGeneProduct
GRB2GeneProduct
GSK3AGeneProduct
GSK3BGeneProduct
HRASGeneProduct3265 (GeneDB)
IGF-1GeneProduct
IGF-1RGeneProduct
IGF-2GeneProduct
IKBKBGeneProduct
IKBKGGeneProduct
IKKGeneProduct
IL1BGeneProduct
IL1RNGeneProduct
IRF1GeneProduct
IRS1GeneProduct
IRS2GeneProduct
ITGB1GeneProduct3688 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProduct
KHDRBS1GeneProduct10657 (Entrez Gene)
LEPProteinLEP (Uniprot-TrEMBL)
LEPRGeneProduct
LigandGeneProduct1950 (Entrez Gene)
MAP2K1GeneProduct
MAP2K2GeneProduct
MAPK1GeneProduct
MAPK14GeneProduct1432 (Entrez Gene)
MAPK3GeneProduct
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MDM2GeneProduct
MTORGeneProduct
MYCGeneProduct
NCOA1GeneProduct8648 (Entrez Gene)
NEK3GeneProduct4752 (Entrez Gene)
NF-kBGeneProduct
NFKB1GeneProduct
NOS3GeneProduct
NOS3GeneProduct4846 (Entrez Gene)
PAK1GeneProduct
PDE3BGeneProduct
PDK1GeneProduct5163 (Entrez Gene)
PI3KGeneProduct
PIAS3GeneProduct10401 (Entrez Gene)
PIK3CAGeneProduct
PIK3CBGeneProduct
PIK3CGGeneProduct
PIK3R1GeneProduct
PIK3R1 GeneProduct
PIK3R2GeneProduct
PIP2GeneProduct
PIP3GeneProduct
PKCGeneProduct
PP1BGeneProduct
PPIAGeneProduct5478 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRLGeneProduct5617 (Entrez Gene)
PRLRGeneProduct
PTK2GeneProduct5747 (Entrez Gene)
PTPN1GeneProduct
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct
PXNGeneProduct
ProteinProtein
RAC1GeneProduct
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct
RELGeneProduct
RELAGeneProduct
RHOAGeneProduct387 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
RPS6KA1GeneProduct
RPS6KB1GeneProduct
RSP6GeneProduct
ReceptorGeneProduct
SH2B1GeneProduct
SHC-1GeneProduct
SIRPAGeneProduct140885 (Entrez Gene)
SOC1GeneProduct
SOC2GeneProduct
SOCS2GeneProduct
SOCS2GeneProduct8835 (Entrez Gene)
SOCS3GeneProduct
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct
SP1GeneProduct6667 (Entrez Gene)
SRCGeneProduct
STAT1GeneProduct
STAT1GeneProduct6772 (Entrez Gene)
STAT1ProteinSTAT1 (Uniprot-TrEMBL)
STAT3GeneProduct
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct
STAT5BGeneProduct6777 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TWIST1GeneProduct7291 (Entrez Gene)
VAV1GeneProduct
VAV2GeneProduct
YWHAZGeneProduct
ZAP70GeneProduct7535 (Entrez Gene)
mRNAProtein
p53GeneProduct
p7056KGeneProduct

Annotated Interactions

No annotated interactions

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