Cell cycle (Homo sapiens)

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1+peG1+p+p-pSeparin+pp21+pDNA damage checkpoint+u+u+p+pM+pG2SecurinSeCondensin+p+u+p+p-pGrowth Factor withdrawal+p+p+u+p+pe+pGrowth Factor+u+peeS-phase proteins,Cyclin ER-point(start)MDM2CDC7SMAD3TGFB1MPEG1CDK2MAPK Signaling PathwayUbiquitin-Mediated ProteolysisMPIP2CDC45APCRB1PMYT1MD2L2CCNB1SMAD4CC14ACDC20CDC6CDKN2ACHK2CDK4ATMCCNE2SKP1CCNB2PRKDCCDK2BUB1CDKN1CMCM2CDKN1ACHK1HDAC2CCNB3CDK6CDK21433GPTTG3CCNA2RBPTTG1CCNA1TBCD8ApoptosisPTTG2ABL1APCBUB1BATRCDK1MD1L1YWHAGSMC1AWEE1CC14BCCNA2MEN1PLK1CADH1BUB3P53GADD45APCNASKP2CCNHESPL1CDKN2ACCND3CCNE1RBHDAC1DBF4AGSK3BRBL1CCND2CCNA1EP300MPIP3MD2L1DNA BiosynthesisCDK1YWHABYWHAEYWHAHYWHAQYWHAZMCM3MCM4MCM5MCM6MCM7ORC1ORC2ORC3ORC4ORC5ORC6SMAD2TGFB2TGFB3RBL1E2F4E2F5TFDP1TFDP2MYCZBTB17CDKN2BCDKN2CCDKN2DCCND1CDKN1BCUL1RBX1E2F1E2F2TFDP1E2F3TFDP2E2F4E2F5TFDP1TFDP2RBL2GADD45BGADD45G


Description

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Sources: Wikipedia:Cell cycle, KEGG

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Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127277view15:52, 1 September 2023Khanspersfixed phospho site
127262view04:52, 30 August 2023Khanspersadded phospho sites
127255view18:16, 28 August 2023Khanspersadded lliterature reference and updated description
127172view06:20, 9 August 2023Fehrhartbox for pathway
127158view23:32, 7 August 2023Khanspersupdated ptms
122978view19:12, 8 June 2022Mkutmonfix unconnected pathway node
122977view19:09, 8 June 2022Mkutmonremoved empty groups
120742view23:40, 27 December 2021EweitzRefine graphics, text; use gene symbols
120027view22:50, 15 October 2021Khanspersupdate phosphosites
120026view20:26, 15 October 2021Khanspersupdate phosphosites
120025view20:12, 15 October 2021Khanspersupdate phosphosites
120024view19:57, 15 October 2021Khanspersupdated phosphosites
116693view15:31, 9 May 2021EweitzModified title
114261view13:57, 2 January 2021EgonwThree more pathways clickable
112039view17:58, 16 September 2020Khanspersupdated phospho site
106351view21:36, 21 August 2019KhanspersModified description
105448view04:58, 8 August 2019KhanspersModified description
105235view13:42, 23 July 2019EgonwNo gene-gene conversion.
103430view16:00, 28 February 2019DeSlRemoved last modified item
97174view17:12, 3 May 2018AlexanderPicochanged complex to paralog group
96994view21:13, 25 April 2018Khanspersadded phosphosites
96993view20:19, 25 April 2018Khanspersinteractions and phosphosites
96985view05:19, 25 April 2018Khanspersoverhaul: updated to Ensembl, added phoshposites, complexes etc
96984view01:20, 25 April 2018Khanspersoverhaul in progress
96983view23:29, 24 April 2018Khanspersoverhaul in progress
93002view18:31, 21 July 2017KhanspersReverted to version '10:59, 16 September 2016' by Khanspers
92878view08:44, 13 July 2017JosipMadunicCell Cycle
89516view10:59, 16 September 2016Mkutmonontology tag fix
89470view13:39, 15 September 2016Mkutmonremove space from ontology term id
70629view00:22, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
69900view19:28, 11 July 2013AlexanderPicoModified title
67101view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
63158view20:18, 8 May 2013MaintBotUpdating gpml version
59175view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45137view00:58, 7 October 2011AlexanderPico
45136view00:57, 7 October 2011AlexanderPicoModified description
45135view00:56, 7 October 2011AlexanderPicoModified description
45134view00:56, 7 October 2011AlexanderPicoModified description
45133view00:55, 7 October 2011AlexanderPicoModified description
45089view21:00, 6 October 2011AlexanderPico
45087view20:58, 6 October 2011AlexanderPicodb refs
45084view20:51, 6 October 2011AlexanderPicofixed pathway refs
45079view20:41, 6 October 2011AlexanderPicoadded groups
45075view20:31, 6 October 2011AlexanderPicoadded groups and db refs
45071view20:14, 6 October 2011AlexanderPicoadded db ref and group
41134view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
35361view09:11, 12 February 2010MartijnVanIerselModified description
34663view12:07, 8 January 2010ThomasReverted color change of gene boxes by BadrulYahaya (no meaning for the color provided)
32357view13:40, 15 August 2009MaintBotFixed text labels
31988view13:13, 14 August 2009MaintBotFixed group labels

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1433GGeneProduct7532 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
ABL1GeneProduct25 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APCGeneProduct324 (Entrez Gene)
ATMGeneProduct472 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProduct545 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
ApoptosisPathwayWP254 (WikiPathways)
BUB1GeneProduct699 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct701 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct9184 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CADH1GeneProduct999 (Entrez Gene)
CC14AGeneProduct8556 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CC14BGeneProduct8555 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CCNA1GeneProduct8900 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct890 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProduct891 (Entrez Gene) CCNB1; cyclin B1
CCNB2GeneProduct9133 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProduct85417 (Entrez Gene) CCNB3; cyclin B
CCND1GeneProductENSG00000110092 (Ensembl) CCND3; cyclin D3
CCND2GeneProduct894 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct896 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct898 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct9134 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct902 (Entrez Gene) CCNH; cyclin H
CDC20GeneProduct991 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC45GeneProduct8318 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct990 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct8317 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDK1GeneProduct983 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDK2GeneProduct1017 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct1019 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct1021 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProductENSG00000111276 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1CGeneProductENSG00000129757 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2AGeneProductENSG00000147889 (Ensembl)
CDKN2BGeneProductENSG00000147883 (Ensembl)
CDKN2CGeneProductENSG00000123080 (Ensembl)
CDKN2DGeneProductENSG00000129355 (Ensembl)
CHK1GeneProduct1111 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHK2GeneProduct11200 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CUL1GeneProductENSG00000055130 (Ensembl)
DBF4AGeneProduct10926 (Entrez Gene) ASK; activator of S phase kinas
DNA BiosynthesisPathway
E2F1GeneProduct1869 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProduct1870 (Entrez Gene) E2F2; E2F transcription factor 2
E2F3GeneProduct1871 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct1874 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F4GeneProductENSG00000205250 (Ensembl)
E2F5GeneProduct1875 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F5GeneProductENSG00000133740 (Ensembl)
EP300GeneProduct2033 (Entrez Gene) EP300; E1A binding protein p300
ESPL1GeneProduct9700 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
HDAC1GeneProduct3065 (Entrez Gene) HDAC1; histone deacetylase 1
HDAC2GeneProduct3066 (Entrez Gene) HDAC2; histone deacetylase 2
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MD1L1GeneProduct8379 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MD2L1GeneProduct4085 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MD2L2GeneProduct10459 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MDM2GeneProduct4193 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MEN1GeneProduct4221 (Entrez Gene)
MPEG1GeneProduct219972 (Entrez Gene)
MPIP2GeneProduct994 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
MPIP3GeneProduct995 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
MYCGeneProductENSG00000136997 (Ensembl)
ORC1GeneProduct4998 (Entrez Gene)
ORC2GeneProduct4999 (Entrez Gene)
ORC3GeneProduct23595 (Entrez Gene)
ORC4GeneProduct5000 (Entrez Gene)
ORC5GeneProduct5001 (Entrez Gene)
ORC6GeneProduct23594 (Entrez Gene)
P53GeneProduct7157 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PLK1GeneProduct5347 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PMYT1GeneProduct9088 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PRKDCGeneProduct5591 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct9232 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProduct10744 (Entrez Gene) PTTG2; pituitary tumor-transforming
PTTG3GeneProduct26255 (Entrez Gene) PTTG3; pituitary tumor-transforming
RB1GeneProductENSG00000139687 (Ensembl)
RBGeneProduct5925 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProductENSG00000080839 (Ensembl)
RBL2GeneProductENSG00000103479 (Ensembl) RB1; retinoblastoma 1 (including osteosarcoma)
RBX1GeneProductENSG00000100387 (Ensembl)
SKP1GeneProductENSG00000113558 (Ensembl)
SKP2GeneProduct6502 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD2GeneProductENSG00000175387 (Ensembl) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD3GeneProduct4088 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct4089 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProduct8243 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBCD8GeneProduct11138 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene) TFDP1; transcription factor Dp-1
TFDP1GeneProductENSG00000198176 (Ensembl)
TFDP2GeneProductENSG00000114126 (Ensembl) TFDP1; transcription factor Dp-1
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
Ubiquitin-Mediated ProteolysisPathwayWP183 (WikiPathways)
WEE1GeneProduct7465 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHABGeneProduct7529 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
YWHAGGeneProduct7532 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)
ZBTB17GeneProductENSG00000116809 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP179"
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