Amino acid conjugation (Homo sapiens)
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Description
Xenobiotic containing a carboxylic acid group (-COOH) or an aromatic hydroxylamine group can be substrates for amino acid conjugation. (Source: http://reactome.org/content/detail/R-HSA-156587) Amino acid conjugation is important in the biotransformation of several xenobiotic carboxylic acids. An amide or peptide bond can be formed between the carboxyl group of the xenobiotic and the amino group of an amino acid, mainly glycine, taurine and glutamine. (Source: Hutt A.J., Caldwell J. Conjugation Reactions In Drug Metabolism; Chapter 10 Amino acid conjugation; 1990.)
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Ontology Terms
Saving...Bibliography
- Knights KM, Sykes MJ, Miners JO; ''Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids.''; Expert Opin Drug Metab Toxicol, 2007 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ATP | Metabolite | HMDB00538 (HMDB)  | |
| Glycine | Metabolite | HMDB00123 (HMDB) | |
| L-Glutamine | Metabolite | HMDB00641 (HMDB) | |
| Phosphate | Metabolite | HMDB01429 (HMDB) | |
| Taurine | Metabolite | HMDB00251 (HMDB) | |
| carboxyl CoA | Metabolite | ||
| carboxyl amino acid conjugate | Metabolite | ||
| carboxylic acid AMP ester | Metabolite | ||
| carboxylic acid | Metabolite | CHEBI:33575 (ChEBI) |
Annotated Interactions
No annotated interactions
