Drug induction of bile acid pathway (Homo sapiens)

From WikiPathways

Revision as of 13:07, 7 June 2018 by Roelod (Talk | contribs)
Jump to: navigation, search
1HepatocyteSensingHepatic UptakeSLCO1B1CYP3A4ChlorpromazineClozapineEzetimibeOSTalphaCyclosporinTroglitazoneBAATTetrahydrocortisoneNR1H4ABCB1Glycocholic acidBA-RSLC10A1CYP7A1SULT2A1Bile AcidsCholesterolMetabolitesBileBile DuctTaurocholic acidBilirubinIsoursodeoxycholic acidDeoxycholic acidVDRNR1I3NR1I2MethylprednisoloneCimetidineOSTBETAABCC4ABCB11ABCC3ABCC2PhospholipidsDigoxinClarithromyciErythromycinSilybinGlyburideTacrolimusTrabectedinPhominColchicineRanitidineOxiglutationeSynthesisConjugationSecretion


Description

Several drug (e.g. chlozapine) and their inhibitory effects on targets of the bile acid production pathway.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. NGP E-Magazine; ''Mechanistic Disease Modeling''; http://www.ngpharma.com/article/Mechanistic-Disease-Modeling/, 2012

History

View all...
CompareRevisionActionTimeUserComment
128660view04:11, 18 February 2024EweitzOntology Term : 'hepatocyte' added !
128659view04:04, 18 February 2024EweitzUse gene symbols, economize layout
120498view07:29, 9 December 2021EgonwReplaced an old PubChem CID with the new one
117705view12:26, 22 May 2021EweitzModified title
106211view12:10, 16 August 2019MaintBotHMDB identifier normalization
97831view06:27, 10 June 2018EgonwModified description
97745view13:07, 7 June 2018RoelodModified description
97743view13:05, 7 June 2018RoelodModified description
88593view19:40, 11 August 2016Mkutmonfix unconnected lines
87242view09:57, 20 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
87241view09:56, 20 July 2016SusanOntology Term : 'drug pathway' added !
78511view10:29, 7 January 2015MaintBotadded missing graphIds
70504view11:46, 8 August 2013EgonwAdded a ChEBI id for the phospholipid compound class.
68912view17:31, 8 July 2013MaintBotUpdated to 2013 gpml schema
60232view21:49, 14 March 2013EgonwAdded a reference to ChEBI for 'bile acid'.
57150view12:35, 23 January 2013EgonwUsed "PubChem-compound"
53119view01:34, 30 October 2012MaintBotModified categories
51078view14:40, 28 August 2012RiannefijtenAdded reference on which the pathway is based
51077view14:32, 28 August 2012RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProduct8647 (Entrez Gene)
ABCB1GeneProduct5243 (Entrez Gene)
ABCC2GeneProduct1244 (Entrez Gene)
ABCC3GeneProduct8714 (Entrez Gene)
ABCC4GeneProduct10257 (Entrez Gene)
BA-RMetabolite
BAATGeneProduct570 (Entrez Gene)
Bile AcidsMetaboliteCHEBI:3098 (ChEBI)
BilirubinMetaboliteHMDB00054 (HMDB)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP7A1GeneProduct1581 (Entrez Gene)
ChlorpromazineMetabolite2726 (PubChem-compound)
CholesterolMetaboliteHMDB00067 (HMDB)
CimetidineMetabolite2756 (PubChem-compound)
ClarithromyciMetabolite84029 (PubChem-compound)
Clozapine Metabolite2818 (PubChem-compound)
Colchicine Metabolite6167 (PubChem-compound)
Cyclosporin Metabolite5284373 (PubChem-compound)
Deoxycholic acidMetaboliteHMDB00626 (HMDB)
DigoxinMetaboliteHMDB01917 (HMDB)
ErythromycinMetabolite12560 (PubChem-compound)
Ezetimibe Metabolite150311 (PubChem-compound)
GlyburideMetabolite3488 (PubChem-compound)
Glycocholic acidMetaboliteHMDB00138 (HMDB)
Isoursodeoxycholic acidMetaboliteHMDB00686 (HMDB)
MethylprednisoloneMetabolite6741 (PubChem-compound)
NR1H4GeneProduct9971 (Entrez Gene)
NR1I2GeneProduct8856 (Entrez Gene)
NR1I3GeneProduct9970 (Entrez Gene)
OSTBETAGeneProduct123264 (Entrez Gene)
OSTalphaGeneProduct200931 (Entrez Gene)
OxiglutationeMetabolite65359 (PubChem-compound)
Phomin Metabolite5311281 (PubChem-compound)
PhospholipidsMetaboliteCHEBI:16247 (ChEBI)
RanitidineMetaboliteHMDB01930 (HMDB)
SLC10A1GeneProduct6554 (Entrez Gene)
SLCO1B1GeneProduct10599 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
SilybinMetabolite31553 (PubChem-compound)
TacrolimusMetabolite445643 (PubChem-compound)
Taurocholic acidMetaboliteHMDB00036 (HMDB)
TetrahydrocortisoneMetaboliteHMDB00903 (HMDB)
Trabectedin Metabolite108150 (PubChem-compound)
TroglitazoneMetabolite5591 (PubChem-compound)
VDRGeneProduct7421 (Entrez Gene)

Annotated Interactions

No annotated interactions

Personal tools