Drug induction of bile acid pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none HepatocyteHepatic uptakeSensingBile acidsCYP7A1CholesterolABCB1SLC51ASLC51BNR1H4VDRNR1I3NR1I2TroglitazoneCyclosporinDigoxinClarithromyciErythromycinSilybinGlyburideGlycocholic acidTaurocholic acidBilirubinIsoursodeoxycholic acidClozapineMethylprednisoloneCimetidineSULT2A1CYP3A4BAATBA-RPhospholipidsSLCO1B1SLC10A1ChlorpromazineEzetimibeTetrahydrocortisoneTacrolimusTrabectedinPhominColchicineRanitidineOxiglutationeBileBile ductDeoxycholic acidABCC4ABCB11ABCC3ABCC2SynthesisConjugationSecretionName: Drug induction of bile acid pathwayOrganism: Homo sapiens


Description

Several drug (e.g. chlozapine) and their inhibitory effects on targets of the bile acid production pathway.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Cell Type : hepatocyte
 

Bibliography

  1. NGP E-Magazine; ''Mechanistic Disease Modeling''; http://www.ngpharma.com/article/Mechanistic-Disease-Modeling/, 2012

History

View all...
CompareRevisionActionTimeUserComment
128660
Approved
view04:11, 18 February 2024EweitzOntology Term : 'hepatocyte' added !
128659view04:04, 18 February 2024EweitzUse gene symbols, economize layout
120498view07:29, 9 December 2021EgonwReplaced an old PubChem CID with the new one
117705view12:26, 22 May 2021EweitzModified title
106211view12:10, 16 August 2019MaintBotHMDB identifier normalization
97831view06:27, 10 June 2018EgonwModified description
97745view13:07, 7 June 2018RoelodModified description
97743view13:05, 7 June 2018RoelodModified description
88593view19:40, 11 August 2016Mkutmonfix unconnected lines
87242view09:57, 20 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
87241view09:56, 20 July 2016SusanOntology Term : 'drug pathway' added !
78511view10:29, 7 January 2015MaintBotadded missing graphIds
70504view11:46, 8 August 2013EgonwAdded a ChEBI id for the phospholipid compound class.
68912view17:31, 8 July 2013MaintBotUpdated to 2013 gpml schema
60232view21:49, 14 March 2013EgonwAdded a reference to ChEBI for 'bile acid'.
57150view12:35, 23 January 2013EgonwUsed "PubChem-compound"
53119view01:34, 30 October 2012MaintBotModified categories
51078view14:40, 28 August 2012RiannefijtenAdded reference on which the pathway is based
51077view14:32, 28 August 2012RiannefijtenNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCB11GeneProduct8647 (Entrez Gene)
ABCB1GeneProduct5243 (Entrez Gene)
ABCC2GeneProduct1244 (Entrez Gene)
ABCC3GeneProduct8714 (Entrez Gene)
ABCC4GeneProduct10257 (Entrez Gene)
BA-RMetabolite
BAATGeneProduct570 (Entrez Gene)
Bile acidsMetaboliteCHEBI:3098 (ChEBI)
BilirubinMetaboliteHMDB0000054 (HMDB)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP7A1GeneProduct1581 (Entrez Gene)
ChlorpromazineMetabolite2726 (PubChem-compound)
CholesterolMetaboliteHMDB0000067 (HMDB)
CimetidineMetabolite2756 (PubChem-compound)
ClarithromyciMetabolite84029 (PubChem-compound)
Clozapine Metabolite135398737 (PubChem-compound)
Colchicine Metabolite6167 (PubChem-compound)
Cyclosporin Metabolite5284373 (PubChem-compound)
Deoxycholic acidMetaboliteHMDB0000626 (HMDB)
DigoxinMetaboliteHMDB0001917 (HMDB)
ErythromycinMetabolite12560 (PubChem-compound)
Ezetimibe Metabolite150311 (PubChem-compound)
GlyburideMetabolite3488 (PubChem-compound)
Glycocholic acidMetaboliteHMDB0000138 (HMDB)
Isoursodeoxycholic acidMetaboliteHMDB0000686 (HMDB)
MethylprednisoloneMetabolite6741 (PubChem-compound)
NR1H4GeneProduct9971 (Entrez Gene)
NR1I2GeneProduct8856 (Entrez Gene)
NR1I3GeneProduct9970 (Entrez Gene)
OxiglutationeMetabolite65359 (PubChem-compound)
Phomin Metabolite5311281 (PubChem-compound)
PhospholipidsMetaboliteCHEBI:16247 (ChEBI)
RanitidineMetaboliteHMDB0001930 (HMDB)
SLC10A1GeneProduct6554 (Entrez Gene)
SLC51AGeneProduct200931 (Entrez Gene)
SLC51BGeneProduct123264 (Entrez Gene)
SLCO1B1GeneProduct10599 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
SilybinMetabolite31553 (PubChem-compound)
TacrolimusMetabolite445643 (PubChem-compound)
Taurocholic acidMetaboliteHMDB0000036 (HMDB)
TetrahydrocortisoneMetaboliteHMDB0000903 (HMDB)
Trabectedin Metabolite108150 (PubChem-compound)
TroglitazoneMetabolite5591 (PubChem-compound)
VDRGeneProduct7421 (Entrez Gene)

Annotated Interactions

No annotated interactions

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