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Hi I think the 11b-HSD enzyme functions are the wrong way around? 11b-HSD1 activates cortisone into cortisol (with minor inactivating activity) and 11b-HSD2 inactivates cortisol to cortisone. Thanks!
Hi Claire,
Would you happen to have a reference where I can check your comment? Then I can adapt accordingly in the pathway, and underpin the change with a reference. You're also allowed to make these changes yourself. If you need any help, let me know!
Kind regards,
DeniseSlenter 12:20, 5 July 2019 (UTC)
Hi Denise,
Sure, this paper should cover it Kotelevtsev et al., 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. PNAS 1997 [1]
Also I tried to edit the pathway myself but was unable to upload it sorry! I got an error message saying something about not having right permissions/account (afraid I can't remember exact wording)
Many thanks,
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Return to Thread:11b-HSD enzyme functions (1).
Since there were a lot of modeling errors in WP237, we've merged the content thereof to a partly overlapping pathway WP4523.
We have also added the reference mentioned above for the conversion from cortisone to cortisol revision 113025.
The current pathway WP237 will be removed.
DeniseSlenter 08:50, 30 October 2020 (UTC)
