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I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b).
I've looked at the paper this pathway is based on and I think they made a mistake. STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade. I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.
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Hi Shamith,
Thank you for reviewing the pathway. You are correct that in this particular case, interactions are not annotated. WikiPathways supports two different ways of adding supporting information to interactions: As an annotated interaction from an interaction database, and by adding a literature reference directly to the interaction.
Since you have expert knowledge in the area of interferon signaling, I would highly recommend that you edit the pathway to correct any incorrect content. After logging in to WikiPathways, simply click "launch editor" under the pathway diagram.
Regards,
Kristina
