Thread:Pathway Incorrect (2)
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from Pathway Talk:WP619
Revision as of 09:27, 20 September 2019.
This is the thread's initial revision.
This is the thread's initial revision.
I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b).
I've looked at the paper this pathway is based on and I think they made a mistake. STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade. I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.
