Acetylcholine binding and downstream events (Homo sapiens)

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Bibliography

1. Itier V, Bertrand D.; ''Neuronal nicotinic receptors: from protein structure to function.''; PubMed Europe PMC Scholia
2. Grottick AJ, Trube G, Corrigall WA, Huwyler J, Malherbe P, Wyler R, Higgins GA.; ''Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.''; PubMed Europe PMC Scholia
3. Fucile S, Renzi M, Lax P, Eusebi F.; ''Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors.''; PubMed Europe PMC Scholia
4. Gotti C, Clementi F, Fornari A, Gaimarri A, Guiducci S, Manfredi I, Moretti M, Pedrazzi P, Pucci L, Zoli M.; ''Structural and functional diversity of native brain neuronal nicotinic receptors.''; PubMed Europe PMC Scholia
5. Albuquerque EX, Pereira EF, Alkondon M, Rogers SW.; ''Mammalian nicotinic acetylcholine receptors: from structure to function.''; PubMed Europe PMC Scholia
6. Steinlein OK, Bertrand D.; ''Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases.''; PubMed Europe PMC Scholia
7. Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, Tzartos SJ.; ''Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties.''; PubMed Europe PMC Scholia
8. Buisson B, Gopalakrishnan M, Arneric SP, Sullivan JP, Bertrand D.; ''Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex	Complex	R-HSA-629600 (Reactome)
AcCho	Metabolite	CHEBI:15355 (ChEBI)
AcCho	Metabolite	CHEBI:15355 (ChEBI)
CHRNA1	Protein	P02708 (Uniprot-TrEMBL)
CHRNA2	Protein	Q15822 (Uniprot-TrEMBL)
CHRNA3	Protein	P32297 (Uniprot-TrEMBL)
CHRNA4	Protein	P43681 (Uniprot-TrEMBL)
CHRNA5	Protein	P30532 (Uniprot-TrEMBL)
CHRNA6	Protein	Q15825 (Uniprot-TrEMBL)
CHRNA7	Protein	P36544 (Uniprot-TrEMBL)
CHRNA9	Protein	Q9UGM1 (Uniprot-TrEMBL)
CHRNB2	Protein	P17787 (Uniprot-TrEMBL)
CHRNB3	Protein	Q05901 (Uniprot-TrEMBL)
CHRNB4	Protein	P30926 (Uniprot-TrEMBL)
CHRND	Protein	Q07001 (Uniprot-TrEMBL)
CHRNE	Protein	Q04844 (Uniprot-TrEMBL)
CHRNG	Protein	P07510 (Uniprot-TrEMBL)
Ca2+	Metabolite	CHEBI:29108 (ChEBI)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Complex	R-HSA-629581 (Reactome)
Highly calcium permeable nicotinic acetylcholine receptors	Complex	R-HSA-629586 (Reactome)
Highly sodium permeable nicotinic acetylcholine receptors	Complex	R-HSA-629576 (Reactome)
Na+	Metabolite	CHEBI:29101 (ChEBI)
O-Acetylcholine bound to Acetylcholine receptor	Complex	R-HSA-629590 (Reactome)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors	Complex	R-HSA-629592 (Reactome)

Annotated Interactions

Source	Target	Type	Database reference	Comment
	0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex	Arrow	R-HSA-629599 (Reactome)
0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex		mim-catalysis	R-HSA-622326 (Reactome)
AcCho			R-HSA-629588 (Reactome)
AcCho			R-HSA-629596 (Reactome)
AcCho			R-HSA-629599 (Reactome)
	Ca2+	Arrow	R-HSA-622326 (Reactome)
	Ca2+	Arrow	R-HSA-629595 (Reactome)
Ca2+			R-HSA-622326 (Reactome)
Ca2+			R-HSA-629595 (Reactome)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors			R-HSA-629596 (Reactome)
Highly calcium permeable nicotinic acetylcholine receptors			R-HSA-629599 (Reactome)
Highly sodium permeable nicotinic acetylcholine receptors			R-HSA-629588 (Reactome)
	Na+	Arrow	R-HSA-622325 (Reactome)
Na+			R-HSA-622325 (Reactome)
	O-Acetylcholine bound to Acetylcholine receptor	Arrow	R-HSA-629588 (Reactome)
O-Acetylcholine bound to Acetylcholine receptor		mim-catalysis	R-HSA-622325 (Reactome)
	O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors	Arrow	R-HSA-629596 (Reactome)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors		mim-catalysis	R-HSA-629595 (Reactome)
			R-HSA-622325 (Reactome)	Nicotinic acetylcholine receptors containing aplha4(2) beta2 (3) and alpha3(2) beta4(3) are selectively highly Na+ permeable upon activation of these receptors by acetylcholine.
			R-HSA-622326 (Reactome)	Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.
			R-HSA-629588 (Reactome)	Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.
			R-HSA-629595 (Reactome)	Acetylcholine binding activates postsynaptic acetylchloine receptors that show Ca2+ currents which facilitate the process of long term potentiation (LTP).
			R-HSA-629596 (Reactome)	Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.
			R-HSA-629599 (Reactome)	Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.