Steroidogenic pathway (Homo sapiens)
From WikiPathways
Description
This pathway describes the production of female sex steroid hormones, which is known as steroidogenesis. Two cell types are involved: theca and granulosa cells.
The final product for this pathway are estrogens (among others 17-beta-estradiol), which are produced from cholesterol. In the theca cell, this process is controlled by the luteinizing hormone (LH), after which androgen molecules diffuse into the granulosa cells.
When the follicles reach maturity, the follicle-stimulating hormone (FSH) stimulates the granulosa cell to convert androgens to estrogens.Quality Tags
Ontology Terms
Saving...Bibliography
- Patel S, Zhou C, Rattan S, Flaws JA; ''Effects of Endocrine-Disrupting Chemicals on the Ovary.''; Biol Reprod, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| Androstenedione | Metabolite | ||
| CYP11A1 | Protein | ||
| CYP17A1 | Protein | ||
| CYP19A1 | Protein | ||
| Cholesterol | Metabolite | ||
| DHEA | Metabolite | ||
| Estradiol | Metabolite | ||
| Estrone | Metabolite | ||
| HSD17B1 | Protein | ||
| HSD3B1 | Protein | ||
| Pregnenolone | Metabolite | ||
| Progesterone | Metabolite | ||
| STAR | Protein | ||
| Testosterone | Metabolite |
Annotated Interactions
No annotated interactions
