Steroidogenic pathway (Homo sapiens)

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1Interactions legend:Theca CellTransport into or between cell(s).Granulosa CellCholesterolSTARCholesterolPregnenoloneDHEAProgesteroneProgesteroneCholesterolPregnenoloneAndrostenedioneAndrostenedioneTestosteroneTestosteroneEstroneEstradiolMolecular conversion.Conversion is catalysed by protein.CYP11A1HSD3B1CYP17A1CYP17A1HSD3B1HSD17B1CYP11A1HSD3B1HSD17B1CYP19A1CYP19A1


Description

This pathway describes the production of female sex steroid hormones, which is known as steroidogenesis. Two cell types are involved: theca and granulosa cells.

The final product for this pathway are estrogens (among others 17-beta-estradiol), which are produced from cholesterol. In the theca cell, this process is controlled by the luteinizing hormone (LH), after which androgen molecules diffuse into the granulosa cells.

When the follicles reach maturity, the follicle-stimulating hormone (FSH) stimulates the granulosa cell to convert androgens to estrogens.

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Ontology Terms

 

Bibliography

  1. Patel S, Zhou C, Rattan S, Flaws JA; ''Effects of Endocrine-Disrupting Chemicals on the Ovary.''; Biol Reprod, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135645view00:05, 9 October 2024Khansperslayout
135644view00:03, 9 October 2024Khanspersadded xrefs, updated layout
123557view17:58, 3 August 2022EgonwMade a pathway clickable
102314view15:47, 18 December 2018EgonwReplaced a secondary ChEBI ID with primary ID.
102276view23:08, 16 December 2018Andraupdated some IDs
101864view16:12, 14 November 2018DeSlAdded link to FSH signaling PW.
101863view16:09, 14 November 2018DeSlAdded signaling part, changed layout slightly
101862view15:54, 14 November 2018DeSlOntology Term : 'granulosa cell' added !
101861view15:54, 14 November 2018DeSlOntology Term : 'theca cell' added !
101860view15:53, 14 November 2018DeSlOntology Term : 'estradiol biosynthetic pathway' added !
101859view15:52, 14 November 2018DeSlModified description
101858view15:46, 14 November 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AndrostenedioneMetabolite
CYP11A1Protein
CYP17A1Protein
CYP19A1Protein
CholesterolMetabolite
DHEAMetabolite
EstradiolMetabolite
EstroneMetabolite
HSD17B1Protein
HSD3B1Protein
PregnenoloneMetabolite
ProgesteroneMetabolite
STARProtein
TestosteroneMetabolite

Annotated Interactions

No annotated interactions

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