Ophthalmate biosynthesis in hepatocytes (Homo sapiens)

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12, 3hepatocyteMRP-transporterCysGCSgamma-Glu-CysGSH2ABgamma-Glu-2ABophthalmate2, 42, 3GS2, 4ophthalmate


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Orlowski M, Wilk S; ''Synthesis of ophthalmic acid in liver and kidney in vivo.''; Biochem J, 1978 PubMed Europe PMC Scholia
  2. Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka T, Tomita M; ''Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Oppenheimer L, Wellner VP, Griffith OW, Meister A; ''Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites.''; J Biol Chem, 1979 PubMed Europe PMC Scholia
  4. Huang CS, Moore WR, Meister A; ''On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.''; Proc Natl Acad Sci U S A, 1988 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134765view00:35, 27 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134764view00:33, 27 July 2024EweitzStandardize case
102376view13:07, 21 December 2018MkutmonLayout
102363view20:58, 20 December 2018EgonwFixed a data source.
102355view19:20, 20 December 2018DeSlOntology Term : 'glutathione metabolic pathway' added !
102354view19:19, 20 December 2018DeSlOntology Term : 'hepatocyte' added !
102353view19:18, 20 December 2018DeSlModified description
102352view19:15, 20 December 2018DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2ABMetaboliteQ27104317 (Wikidata) aka 2-aminobutyrate
CysMetaboliteQ186474 (Wikidata)
GCSProtein6.3.2.2 (Enzyme Nomenclature) aka Glutamate Cysteine Ligase (GCL) (EC 6.3.2.2), previously known as gamma-glutamylcysteine synthetase (GCS)
GSProtein6.3.2.3 (Enzyme Nomenclature) aka Glutathione synthetase (GSS)
GSHMetaboliteQ116907 (Wikidata) aka glutathione
MRP-transporterProtein
gamma-Glu-2ABMetabolite78437958 (Wikidata) aka gamma-Glutamyl-2-aminobutyrate
gamma-Glu-CysMetaboliteQ288236 (Wikidata)
ophthalmateMetaboliteQ7098084 (TTD Drug) aka ophthalmic acid
ophthalmateMetaboliteQ7098084 (Wikidata) aka ophthalmic acid

Annotated Interactions

No annotated interactions

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