Neovascularization processes (Homo sapiens)

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HSCNotch1/4De novo arteriogenesisVEGFR3VEGFR2VEGFDLL2ERK1/2PI3K/AktJNK1/2FAKNRP1ProliferationTube formationMigrationApoptosisAngiogenesisIntegrinsNOMMP9mKitLsKitLcKitStalk ECArteriolar specificationVEGF signallingNotch signallingDLL4JAG1ECPericytesTip ECSprouting angiogenesisNOTCH3CXCR4SDF-1VasculogenesisSMCMSCSMCEPCEPHB4Cell recruitmentVessel maturationPDGF-BBRemodeling arteriogenesisAng-1PDGF-βVEGFRSDF-VEGFHIF-1αShear stressNF-κBCell differentiationMatrix and collagendepositionTGF-β1TGF-β2TGF-β3Smad1/5/8Smad2/3TβRALK1ALK5TGF-β signallingEPHB2


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Murakami M, Simons M; ''Fibroblast growth factor regulation of neovascularization.''; Curr Opin Hematol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135060view12:47, 2 August 2024EweitzEconomize layout
135059view12:45, 2 August 2024EweitzEconomize layout
128749view07:59, 21 February 2024EgonwFixed the datasource of a Ensembl identifier
128748view07:57, 21 February 2024EgonwMade four pathways clickable
127967view14:49, 20 January 2024EweitzIdentify more pathways, refine style
127966view14:47, 20 January 2024EweitzIdentify some pathways
127965view14:44, 20 January 2024EweitzModified description
127964view14:41, 20 January 2024EweitzStandardize names of genes and pathways
127963view14:34, 20 January 2024EweitzModified title
127962view14:19, 20 January 2024EweitzOntology Term : 'pericyte' added !
127961view14:19, 20 January 2024EweitzOntology Term : 'smooth muscle cell' added !
107654view08:33, 25 October 2019DeSlAnnotated last GeneProduct Nodes (if possible), changed some to PW nodes (containing "signalling").
107653view08:21, 25 October 2019DeSlAdded more IDs, split up Notch1/4 in two GeneProducts.
107652view08:14, 25 October 2019DeSlAdded several IDs for bottom right.
107651view07:58, 25 October 2019DeSlChanged some GeneProducts to PW nodes (since these describe processes, not individual genes).
107650view07:55, 25 October 2019DeSlChanged MIM-conversions to arrow (since this PW doesn't include metabolites).
107649view07:52, 25 October 2019DeSlConnected last unconnected line.
107648view07:50, 25 October 2019DeSlUpdated not UTF-8 encoded characters
102451view14:28, 23 December 2018DeSlModified description
102450view14:24, 23 December 2018DeSlAdded general lit. ref
102449view14:20, 23 December 2018DeSlAnnotated left bottom side
102448view14:15, 23 December 2018DeSlAnnotated right bottom side
102447view14:05, 23 December 2018DeSlAnnotated right top side
102446view13:56, 23 December 2018DeSlAnnotated top left corner
102362view20:11, 20 December 2018FehrhartOntology Term : 'cardiovascular system homeostasis pathway' added !
102361view20:09, 20 December 2018FehrhartOntology Term : 'endothelial cell' added !
102360view20:07, 20 December 2018Fehrhartconnected unconnected lines
98401view22:06, 31 August 2018CarlosaxgNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALK1 GeneProduct
ALK5 GeneProduct
Ang-1 PDGF-βGeneProduct
AngiogenesisPathway
ApoptosisPathway
Arteriolar specificationPathway
CXCR4GeneProductENSG00000121966 (Ensembl)
Cell differentiationPathway
Cell recruitmentPathway
DLL2GeneProduct
DLL4GeneProductENSG00000128917 (Ensembl)
De novo arteriogenesisPathway
EPHB2GeneProductENSG00000133216 (Ensembl)
EPHB4GeneProductENSG00000196411 (Ensembl)
ERK1/2

PI3K/Akt JNK1/2

FAK		GeneProduct
HIF-1αGeneProduct
IntegrinsGeneProduct
JAG1GeneProductENSG00000101384 (Ensembl)
MMP9GeneProduct
Matrix and

collagen

deposition		Pathway
MigrationPathway
NF-κB GeneProduct
NOGeneProduct
NOTCH3GeneProductENSG00000074181 (Ensembl)
NRP1GeneProduct
Notch signallingGeneProduct
Notch1/4GeneProduct
PDGF-BBGeneProduct
ProliferationPathway
Remodeling arteriogenesisPathway
SDF-1GeneProduct
Shear stressPathway
Smad 1/5/8GeneProduct
Smad 2/3GeneProduct
Sprouting angiogenesisPathway
TGF-β signallingGeneProduct
TGF-β1GeneProduct
TGF-β2GeneProduct
TGF-β3GeneProduct
Tube formationPathway
TβR GeneProduct
VEGF signallingGeneProduct
VEGFGeneProductIPR000072 (InterPro)
VEGFR

SDF-

VEGF		GeneProduct
VEGFR2GeneProductENSG00000128052 (Ensembl) aka KDR
VEGFR3GeneProductENSG00000037280 (Ensembl) aka FLT4
VasculogenesisPathway
Vessel maturationPathway
cKitGeneProduct
mKitLGeneProduct
sKitLGeneProduct

Annotated Interactions

No annotated interactions

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