Elongation of (very) long chain fatty acids (Mus musculus)
From WikiPathways
Description
This pathway depicts the key steps in (very) long-chain fatty acid biosynthesis, belonging to the n-10, 9 and 7 series.
These are mainly synthesised from palmitic acid (C16:0), which is produced by FAS (fatty acid synthase). The n-6 and 3 series can only be obtained from precursors in food.
The elongation steps (addition of carbohydrates, increasing length of tail) are carried out by several Elovl-proteins, while the desaturation (removal of hydrogens, creating double bonds within the tail) are possible by SCDs and Fads.Quality Tags
Ontology Terms
Bibliography
- Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM; ''Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.''; Nature, 2019 PubMed Europe PMC Scholia
- Guillou H, Zadravec D, Martin PG, Jacobsson A; ''The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.''; Prog Lipid Res, 2010 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
C16:0 | Metabolite | CHEBI:15756 (ChEBI) | |
C16:1 | Metabolite | CCCCCCCCC=CCCCCCC(=O)O C16:1 (omega-9) | |
C16:2 | Metabolite | ||
C18:0 | Metabolite | Q209685 (Wikidata) | |
C18:1 | Metabolite | ||
C18:1 | Metabolite | CCCCCCCCC=CCCCCCCCC(=O)O C18:1 (omega-9) | |
C18:2 | Metabolite | ||
C18:3 | Metabolite | ||
C18:4 | Metabolite | ||
C20:0 | Metabolite | CHEBI:28822 (ChEBI) | |
C20:1 | Metabolite | ||
C20:2 | Metabolite | ||
C20:3 | Metabolite | ||
C20:4 | Metabolite | ||
C20:5 | Metabolite | ||
C22:0 | Metabolite | Q422590 (Wikidata) | |
C22:1 | Metabolite | ||
C22:3 | Metabolite | ||
C22:4 | Metabolite | ||
C22:5 | Metabolite | ||
C22:6 | Metabolite | ||
C24:0 | Metabolite | Q422634 (Wikidata) | |
C24:1 | Metabolite | ||
C24:4 | Metabolite | ||
C24:5 | Metabolite | ||
C24:6 | Metabolite | ||
C26:0 | Metabolite | Q903348 (Wikidata) | |
C28:0 | Metabolite | ||
C30:0 | Metabolite | ||
C34:5 | Metabolite | ||
C34:6 | Metabolite | ||
Elovl1 | Protein | ENSMUSG00000006390 (Ensembl) | |
Elovl2 | GeneProduct | ENSMUSG00000021364 (Ensembl) | |
Elovl3 | Protein | ENSMUSG00000038754 (Ensembl) | |
Elovl4 | GeneProduct | ENSMUSG00000032262 (Ensembl) | |
Elovl5 | Protein | ||
Elovl5 | GeneProduct | ENSMUSG00000032349 (Ensembl) | |
Elovl6 | Protein | ||
Elovl6 | GeneProduct | ENSMUSG00000041220 (Ensembl) | |
Elovl7 | Protein | ENSMUSG00000021696 (Ensembl) | |
Fas | GeneProduct | ENSMUSG00000025153 (Ensembl) | |
Perox. beta-ox | Protein | ||
SCD1 | Protein | ||
SCD2 | Protein | ||
SCD4 | Protein | ||
Unknown | Metabolite | ||
delta-5 Fads1 | Protein | ENSMUSG00000010663 (Ensembl) | |
delta-5 ? | Protein | ENSMUSG00000010663 (Ensembl) | |
delta-6 Fads2 ? | Protein | ENSMUSG00000024665 (Ensembl) | Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia) |
delta-6 Fads2 | Protein | ENSMUSG00000024665 (Ensembl) | Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia) |
delta-8 Fads2 | Protein | Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia) | |
delta-9 SCD1 | Protein | ||
delta-9 SCD3 | Protein |
Annotated Interactions
No annotated interactions