Elongation of (very) long chain fatty acids (Mus musculus)

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1DIETomega 10 (or n-10) family?Unknowndelta-6 Fads2C20:2FasC16:1C18:2C18:2Elovl6C18:1C16:0C18:0C20:0C16:1C18:1C16:2C18:3C20:3C18:2C20:2C20:3C22:3C18:1C20:1C22:1C24:1omega 9 (or n-9) familyomega 6 (or n-6) familyC22:0C24:0C26:0C28:0C30:0Saturated fatty acidsElovl5Elovl5delta-5 Fads1Elovl3Elovl3Elovl3delta-9 SCD3SCD1SCD2SCD4delta-6 Fads2 ?delta-6 Fads2SCD2SCD4delta-9 SCD1Elovl3Elovl1Elovl7Elovl6Elovl3Elovl1Elovl7Elovl3Elovl1Elovl7Elovl3Elovl1Elovl4C18:3C18:3C18:3C20:3C20:3C20:4C22:4C24:4C24:5C22:5C34:5C18:4C20:4C20:5C22:5C24:5C24:6C22:6C20:3C34:6Elovl5delta-6 Fads2delta-5 ? Elovl5?delta-5 Fads1Elovl5Elovl2Elovl2delta-6 Fads2Elovl4Elovl2Perox. beta-oxElovl4Elovl2delta-8 Fads2Elovl5Elovl5delta-6 Fads2omega 7 (or n-7) familyomega 3 (or n-3) family


Description

This pathway depicts the key steps in (very) long-chain fatty acid biosynthesis, belonging to the n-10, 9 and 7 series.

These are mainly synthesised from palmitic acid (C16:0), which is produced by FAS (fatty acid synthase). The n-6 and 3 series can only be obtained from precursors in food.

The elongation steps (addition of carbohydrates, increasing length of tail) are carried out by several Elovl-proteins, while the desaturation (removal of hydrogens, creating double bonds within the tail) are possible by SCDs and Fads.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM; ''Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.''; Nature, 2019 PubMed Europe PMC Scholia
  2. Guillou H, Zadravec D, Martin PG, Jacobsson A; ''The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.''; Prog Lipid Res, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125976view15:58, 23 March 2023DeSlAdded info on uncertainty of existance for C18:3
125917view02:26, 18 March 2023AlexanderPicomanual sync
125884view14:37, 16 March 2023Conroy lipidsfix more cross refs
125883view14:14, 16 March 2023Conroy lipidscorrected more erroneous identifiers for lipids
125882view13:47, 16 March 2023Conroy lipidsmetabolite IDs changed for lipidmaps IDs and updated for correct metabolites (previous ones had incorrect double bond position and geometry)
125771view15:12, 9 March 2023DeSlAdded last missing metabolite
125770view15:10, 9 March 2023DeSlAnnotated bottom section
125769view15:06, 9 March 2023DeSlAnnotated purple section
125768view14:58, 9 March 2023DeSlFinished annotating top half
125767view14:56, 9 March 2023DeSlAnnotated top 2 sections based on SMILES
107306view14:40, 19 September 2019EgonwRemoved an empty ChEBI identifier
107208view14:30, 17 September 2019MaintBotChEBI identifier normalization
103499view14:31, 6 March 2019DeSlAdded proteins for C16:1 -> C18:1 omega 10 conversion.
102579view13:42, 9 January 2019DeSlAdded excess carbohydrates Node as substrate for C16:0
102578view13:37, 9 January 2019DeSlAdded SMILES for Omega-3 series.
102577view13:23, 9 January 2019DeSlAdded SMILES in comments for Omega 6 series.
102576view13:07, 9 January 2019DeSlAnnotated saturated fatty acid serie.
102575view12:56, 9 January 2019DeSlAdded SMILES in comments for omega 9 and 7 family.
102574view12:43, 9 January 2019DeSlAnnotated missing Elovl5+6
102573view12:40, 9 January 2019DeSlAdded delta information as text lables (iso in the protein nodes).
102571view13:27, 8 January 2019DeSlModified description
102570view13:25, 8 January 2019DeSlAnnotated SCD3
102569view13:23, 8 January 2019DeSlAnnotated SCD series (except nr3)
102568view13:19, 8 January 2019DeSlAdded "aka name" in comment for C(18:1)n-10
102567view13:07, 8 January 2019DeSlAnnotated more lipids (with names from Fig.1 of main publication).
102558view16:00, 7 January 2019DeSlOntology Term : 'fatty acid metabolic pathway' added !
102557view16:00, 7 January 2019DeSlOntology Term : 'fatty acid biosynthetic pathway' added !
102556view15:59, 7 January 2019DeSlOntology Term : 'fatty acid elongation pathway' added !
102555view15:57, 7 January 2019DeSlModified description
102554view15:52, 7 January 2019DeSlLayout changes
102551view15:50, 7 January 2019DeSlAdded background for omage 6 and 3 compounds
102550view15:15, 7 January 2019DeSlAdded proteins for bottom half
102549view15:00, 7 January 2019DeSlAdded bottom half of figure
102548view14:49, 7 January 2019DeSlAdded SMILES for some lipids in the comment section (will annotate later with specific ID).
102547view13:50, 7 January 2019DeSlModified description
102546view13:47, 7 January 2019DeSlAnnotated more proteins
102545view13:22, 7 January 2019DeSlAnnotated Elovl proteins
102544view13:17, 7 January 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C16:0MetaboliteCHEBI:15756 (ChEBI) AKA Palmitic Acid
C16:1MetaboliteQ2823304 (Wikidata)
  • CCCCCCCCCC=CCCCCC(=O)O C16:1 (omega-10)
  • AKA Sapienic acid
C16:1MetaboliteQ412366 (Wikidata)
  • CCCCCCCCC=CCCCCCC(=O)O C16:1 (omega-9)
  • AKA Palmitoleic acid
C16:2Metabolite
C18:0MetaboliteQ209685 (Wikidata) AKA Stearic acid
C18:1MetaboliteQ207688 (Wikidata) AKA oleic acid
C18:1MetaboliteQ27116670 (Wikidata)
  • CCCCCCCCC=CCCCCCCCC(=O)O C18:1 (omega-9)
  • AKA Vaccenic acid
  • Annotated as cis/trans group.
C18:1Metabolite
  • CCCCCCCCCC=CCCCCCCC(=O)O C18:1 (omega-10)
  • aka sebaleic acid (name unknown in Wikidata!)
C18:2Metabolite
C18:2MetaboliteQ407426 (Wikidata) AKA Linoleic Acid
C18:3Metabolite
C18:3MetaboliteQ256502 (Wikidata) AKA alpha-linolenic acid
C18:4Metabolite
C20:0MetaboliteCHEBI:28822 (ChEBI) AKA Arachidic acid
C20:1MetaboliteQ5516412 (Wikidata) AKA gadoleic acid and eicosenoic acid
C20:2Metabolite
C20:3Metabolite
C20:3MetaboliteQ416610 (Wikidata) AKA Mead acid
C20:4Metabolite
C20:4MetaboliteQ407699 (Wikidata) AKA arachidonic acid
C20:5MetaboliteQ409990 (Wikidata) AKA eicosapentaenoic acid
C22:0MetaboliteQ422590 (Wikidata) AKA Behenic Acid
C22:1MetaboliteQ413531 (Wikidata) AKA Erucic acid
C22:3Metabolite
C22:4Metabolite
C22:5Metabolite
C22:5MetaboliteQ2823253 (Wikidata) AKA Docosapentaenoic acid
C22:6MetaboliteQ423345 (Wikidata) AKA docosahexaenoic acid
C24:0MetaboliteQ422634 (Wikidata) AKA Lignoceric acid
C24:1Metabolite
C24:4Metabolite
C24:5Metabolite
C24:6Metabolite
C26:0MetaboliteQ903348 (Wikidata)
C28:0Metabolite
C30:0Metabolite
C34:5Metabolite
C34:6Metabolite
Elovl1ProteinENSMUSG00000006390 (Ensembl)
Elovl2GeneProductENSMUSG00000021364 (Ensembl)
Elovl3ProteinENSMUSG00000038754 (Ensembl)
Elovl4GeneProductENSMUSG00000032262 (Ensembl)
Elovl5Protein
Elovl5GeneProductENSMUSG00000032349 (Ensembl)
Elovl6Protein
Elovl6GeneProductENSMUSG00000041220 (Ensembl)
Elovl7ProteinENSMUSG00000021696 (Ensembl)
FasGeneProductENSMUSG00000025153 (Ensembl)
Perox. beta-oxProtein
SCD1ProteinENSMUSG00000037071 (Ensembl)
SCD2ProteinP13011 (Uniprot-TrEMBL)
SCD4ProteinQ6T707 (Uniprot-TrEMBL)
UnknownMetabolite
delta-5 Fads1ProteinENSMUSG00000010663 (Ensembl)
delta-5 ? ProteinENSMUSG00000010663 (Ensembl)
delta-6 Fads2 ?ProteinENSMUSG00000024665 (Ensembl) Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)
delta-6 Fads2ProteinENSMUSG00000024665 (Ensembl) Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)
delta-8 Fads2ProteinAnnotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)
delta-9 SCD1ProteinENSMUSG00000037071 (Ensembl)
delta-9 SCD3Protein

Annotated Interactions

No annotated interactions

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