IL10 anti-inflammatory signaling (Homo sapiens)

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1, 2+LPS induced pathwayNucleusJAK/STAT inducedgenesDNAMacrophage cytoplasmInflammatory cytokinegenesSTAT1IL6p38 MAPK pathwaySTAT3JAK1BLVRBHMOX1IL10RABiliverdinBLVRACOIL1AIL10HemeBilirubinTNFIL10RBSTAT2HMOX1DNA


Description

IL-10 Anti-inflammatory Signaling Pathway.

Pathway based on Biocarta pathway (M6778).

https://cgap.nci.nih.gov/Pathways/BioCarta/h_il10Pathway

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Quality Tags

Ontology Terms

 

Bibliography

  1. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, Tripathy SP, Suar M, Pandey A, Gandotra S, Prasad TS, Shankar S; ''A network map of Interleukin-10 signaling pathway.''; J Cell Commun Signal, 2016 PubMed Europe PMC Scholia
  2. Hutchins AP, Diez D, Miranda-Saavedra D; ''The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges.''; Brief Funct Genomics, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129721view01:33, 22 May 2024EweitzModified title
128412view13:01, 4 February 2024EweitzRefine cell type name, expand uncommon abbreviation, tailor pathway node heights
128411view12:54, 4 February 2024EweitzOntology Term : 'macrophage' added !
125654view15:55, 6 March 2023DeSlOntology Term : 'Interleukin-10 signaling pathway' added !
125652view15:53, 6 March 2023DeSlConnected unconnected line
125634view02:03, 6 March 2023AlexanderPicoModified description
123501view04:58, 29 July 2022EgonwMade a pathway clickable
117759view12:53, 22 May 2021EweitzModified title
102692view15:42, 19 January 2019FehrhartOntology Term : 'signaling pathway' added !
102664view12:53, 16 January 2019LaurentModified description
102649view09:19, 16 January 2019LaurentUpdated literature
102648view09:12, 16 January 2019LaurentAdded metabolite and pathway nodes. Fixed interactions
102621view13:54, 14 January 2019LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BLVRAGeneProduct644 (Entrez Gene)
BLVRBGeneProduct645 (Entrez Gene)
BilirubinMetaboliteQ104219 (Wikidata)
BiliverdinMetaboliteQ422964 (Wikidata)
COMetaboliteQ2025 (Wikidata)
HMOX1GeneProduct3162 (Entrez Gene)
HemeMetaboliteQ189621 (Wikidata)
IL10GeneProduct3586 (Entrez Gene)
IL10RAGeneProduct3587 (Entrez Gene)
IL10RBGeneProduct3588 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TNFGeneProduct7214 (Entrez Gene)
p38 MAPK pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4495"
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