Genes related to primary cilium development (based on CRISPR) (Homo sapiens)
From WikiPathways
Description
The primary cilium is related Hedgehog signaling, embryonic and brain[1] development. When it is disregulated, it leads to ciliopathies[2].
The genes in this pathway are related to several ciliary structures, which have been discovered with genome-wide CRISPR-mediated gene disruption.
Quality Tags
Ontology Terms
Bibliography
- Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV; ''A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.''; Nat Genet, 2018 PubMed Europe PMC Scholia
- Waters AM, Beales PL; ''Ciliopathies: an expanding disease spectrum.''; Pediatr Nephrol, 2011 PubMed Europe PMC Scholia
- Youn YH, Han YG; ''Primary Cilia in Brain Development and Diseases.''; Am J Pathol, 2018 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
ARL13B | GeneProduct | 200894 (Entrez Gene) | ARL13B |
ARL3 | GeneProduct | 403 (Entrez Gene) | |
ARL6 | GeneProduct | ARL6 (HGNC) | |
ARMC9 | GeneProduct | 80210 (Entrez Gene) | |
B9D1 | GeneProduct | 27077 (Entrez Gene) | B9D1 |
BBS10 | GeneProduct | 79738 (Entrez Gene) | |
BBS12 | GeneProduct | 166379 (Entrez Gene) | |
BBS1 | GeneProduct | 582 (Entrez Gene) | BBS |
BBS2 | GeneProduct | 583 (Entrez Gene) | BBS |
BBS4 | GeneProduct | 585 (Entrez Gene) | BBS |
BBS5 | GeneProduct | 129880 (Entrez Gene) | BBS |
BBS7 | GeneProduct | 55212 (Entrez Gene) | BBS |
BBS9 | GeneProduct | 27241 (Entrez Gene) | BBS |
BGD2 | GeneProduct | ||
C2CD3 | GeneProduct | 26005 (Entrez Gene) | TEDC1 |
C5orf42 | GeneProduct | 65250 (Entrez Gene) | RABL2A |
CBY1 | GeneProduct | 25776 (Entrez Gene) | CBY1 |
CC2D2A | GeneProduct | 57545 (Entrez Gene) | |
CDK20 | GeneProduct | 23552 (Entrez Gene) | |
CEP104 | GeneProduct | 9731 (Entrez Gene) | |
CEP120 | GeneProduct | 153241 (Entrez Gene) | TEDC2 |
CEP162 | GeneProduct | 22832 (Entrez Gene) | CEP192 |
CEP192 | GeneProduct | 55125 (Entrez Gene) | CEP192 |
CEP19 | GeneProduct | 84984 (Entrez Gene) | RABL2A |
CEP295 | GeneProduct | 85459 (Entrez Gene) | CEP192 |
CEP44 | GeneProduct | 80817 (Entrez Gene) | TEDC2 |
CEP76 | GeneProduct | 79959 (Entrez Gene) | CEP76 |
CEP83 | GeneProduct | 51134 (Entrez Gene) | |
CEP97 | GeneProduct | 79598 (Entrez Gene) | CEP192 |
CLUAP1 | GeneProduct | 23059 (Entrez Gene) | CLUAP1 |
DYNC2H1 | GeneProduct | ENSG00000187240 (Ensembl) | |
DYNC2LI1 | GeneProduct | ENSG00000138036 (Ensembl) | |
DYNLL1 | GeneProduct | ENSG00000088986 (Ensembl) | |
DYNLT1 | GeneProduct | ENSG00000146425 (Ensembl) | |
EFCAB7 | GeneProduct | 84455 (Entrez Gene) | |
EVC | GeneProduct | 2121 (Entrez Gene) | |
EVC2 | GeneProduct | 132884 (Entrez Gene) | |
FAM92A | GeneProduct | 137392 (Entrez Gene) | FAM92A |
FBF1 | GeneProduct | 85302 (Entrez Gene) | |
FGFR1OP | GeneProduct | 11116 (Entrez Gene) | CEP76 |
FOPNL | GeneProduct | 123811 (Entrez Gene) | RABL2A |
FUZ | GeneProduct | 80199 (Entrez Gene) | RABL2A |
HSPB11 | GeneProduct | 51668 (Entrez Gene) | HSPB11 |
ICK | GeneProduct | 22858 (Entrez Gene) | |
IFT122 | GeneProduct | 55764 (Entrez Gene) | |
IFT140 | GeneProduct | 9742 (Entrez Gene) | |
IFT172 | GeneProduct | ENSG00000138002 (Ensembl) | |
IFT20 | GeneProduct | 90410 (Entrez Gene) | IFT20 |
IFT27 | GeneProduct | ENSG00000100360 (Ensembl) | |
IFT43 | GeneProduct | 112752 (Entrez Gene) | |
IFT46 | GeneProduct | 56912 (Entrez Gene) | IFT46 |
IFT52 | GeneProduct | ENSG00000101052 (Ensembl) | |
IFT57 | GeneProduct | ENSG00000114446 (Ensembl) | |
IFT74 | GeneProduct | ENSG00000096872 (Ensembl) | |
IFT80 | GeneProduct | 57560 (Entrez Gene) | IFT80 |
IFT81 | GeneProduct | ENSG00000122970 (Ensembl) | |
IFT88 | GeneProduct | 8100 (Entrez Gene) | IFT88 |
INPP5E | GeneProduct | 56623 (Entrez Gene) | |
IQCE | GeneProduct | 23288 (Entrez Gene) | |
KATNB1 | GeneProduct | 10300 (Entrez Gene) | KATNB1 |
KIAA0753 | GeneProduct | 9851 (Entrez Gene) | RABL2A |
KIF3A | GeneProduct | KIF3A (HGNC) | |
KIF3B | GeneProduct | KIF3B (HGNC) | |
KIFAP3 | GeneProduct | 22920 (Entrez Gene) | |
LZTFL1 | GeneProduct | 54585 (Entrez Gene) | |
MIB1 | GeneProduct | 57534 (Entrez Gene) | CEP192 |
MKKS | GeneProduct | 8195 (Entrez Gene) | |
MKS1 | GeneProduct | 54903 (Entrez Gene) | |
OFD1 | GeneProduct | 8481 (Entrez Gene) | RABL2A |
PIBF1 | GeneProduct | 10464 (Entrez Gene) | TEDC1 |
RAB23 | GeneProduct | 51715 (Entrez Gene) | |
RABL2A | GeneProduct | 11159 (Entrez Gene) | RABL2A |
RPGRIP1L | GeneProduct | 23322 (Entrez Gene) | RPGRIP1 |
RSG1 | GeneProduct | 79363 (Entrez Gene) | RABL2A |
SASS6 | GeneProduct | 163786 (Entrez Gene) | CEP192 |
SCLT1 | GeneProduct | 132320 (Entrez Gene) | |
TCTEX1D2 | GeneProduct | ENSG00000213123 (Ensembl) | |
TCTN1 | GeneProduct | 79600 (Entrez Gene) | |
TCTN2 | GeneProduct | 79867 (Entrez Gene) | CBY1 |
TCTN3 | GeneProduct | 26123 (Entrez Gene) | TCTN3 |
TEDC1 | GeneProduct | 283643 (Entrez Gene) | TEDC1 |
TEDC2 | GeneProduct | 80178 (Entrez Gene) | TEDC2 |
TMEM107 | GeneProduct | 84314 (Entrez Gene) | TMEM107 |
TMEM17 | GeneProduct | 200728 (Entrez Gene) | TMEM17 |
TMEM216 | GeneProduct | 51259 (Entrez Gene) | TMEM216 |
TMEM231 | GeneProduct | 79583 (Entrez Gene) | TMEM216 |
TMEM67 | GeneProduct | 91147 (Entrez Gene) | TMEM67 |
TRAF3IP1 | GeneProduct | ENSG00000204104 (Ensembl) | |
TRAPPC11 | GeneProduct | 60684 (Entrez Gene) | |
TTBK2 | GeneProduct | 146057 (Entrez Gene) | TEDC2 |
TTC21B | GeneProduct | TTC21B (HGNC) | |
TTC23 | GeneProduct | TTC23 (HGNC) | |
TTC26 | GeneProduct | ENSG00000105948 (Ensembl) | |
TTC30B | GeneProduct | ENSG00000196659 (Ensembl) | |
TTC8 | GeneProduct | 123016 (Entrez Gene) | BBS |
TUBD1 | GeneProduct | 51174 (Entrez Gene) | TEDC2 |
TUBE1 | GeneProduct | 51175 (Entrez Gene) | KATNB1 |
TULP3 | GeneProduct | 7289 (Entrez Gene) | |
TXNDC15 | GeneProduct | 79770 (Entrez Gene) | TXNDC15 |
WDPCP | GeneProduct | 51057 (Entrez Gene) | CEP76 |
WDR19 | GeneProduct | 57728 (Entrez Gene) | |
WDR34 | GeneProduct | ENSG00000119333 (Ensembl) | |
WDR35 | GeneProduct | 57539 (Entrez Gene) | |
WDR60 | GeneProduct | ENSG00000126870 (Ensembl) |
Annotated Interactions
No annotated interactions