Regulatory circuits of STAT3 signaling (Homo sapiens)

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1Type II receptorsphosphorilationG-protein coupled receptorsReceptors with shared yc (IL2RG)-subunitReceptor tyrosine kinasesplaceholdermiR-135a-5pmiR-17-5pmiR-29bmiR-124miR-519aHomodimeric cytokine receptorsReceptors with shared GP130 (IL6ST) subunitReceptors with shared Bc (CSF2RB)-subunitMAPK7PTPRTOSMRAGTR2MPLRICTORPDGFRBMAPK11SOCS3IL2RBIFNGR1PIAS3SETD7MAPK15MAPK1IL20RAMAPK3MAPK14IL6STIL20RBCSF2RBIFNAR1RPTORIL15RAGHRIFNLR1CSF2RAIL2RGIL27RACREBBPJAK1IL12RB2IL10RBMAPK12AKT1S1EGFRIL22RA1PRKCBSRCIL10RAF2RL2IL3RAIL21RPTPRDCNTFRJAK2MAPK6CSF3RSTMN1LIFRPDGFRAIFNAR2IL7RMAPKAP1IL9RSTAT3MLST8JAK3TYK2F2RL3MLST8TRIM28IL6RCTF1MAPK8IFNGR2IL11RAIL2RAMAPK10IL5RAMTORPTPRCMAPK9DUSP2DEPTORAGTR1MAPK13F2RSTAT3STAT3STAT3MAPK4MTORIL6STIL6STIL6STIL6STIL6STIL6STIL6STIL2RGIL2RGIL2RBIL2RGIL2RGCSF2RBCSF2RBGHRMPLCSF3RIL10RBIL10RAIL10RBIL22RA1IL20RBIL10RBPDGFRAPDGFRBPDGFRBPDGFRASTAT3STAT3dephosphorilationphosphorilationdephosphorilationplaceholdermiR-19aplaceholdermiR-7aJAK1JAK1JAK1JAK2JAK2JAK2JAK2TYK2JAK2TYK2


Description

In progress

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Quality Tags

Ontology Terms

 

Bibliography

  1. Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J; ''Viral manipulation of STAT3: Evade, exploit, and injure.''; PLoS Pathog, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129731view01:43, 22 May 2024EweitzModified title
104390view13:38, 23 May 2019Marvin M2Modified description
104330view13:54, 17 May 2019FehrhartOntology Term : 'Jak-Stat signaling pathway' added !
104010view14:45, 25 April 2019Marvin M2Added all chemical conversions
103689view16:32, 28 March 2019Marvin M2Added binding information
103381view09:13, 25 February 2019DeSlAdded more details about dephosphorylation/phosphorylation modifications.
103379view09:03, 25 February 2019DeSlAdded some details as requested by Marvin
103333view12:24, 22 February 2019DeSlOntology Term : 'regulatory pathway' added !
103332view12:01, 22 February 2019Marvin M2Removed abundant nodes
103331view12:00, 22 February 2019Marvin M2Added most receptors, and connected parts where possible. Still work needs to be done
103306view16:35, 21 February 2019Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGTR1GeneProductAGTR1 (HGNC)
AGTR2GeneProductAGTR2 (HGNC)
AKT1S1GeneProductAKT1S1 (HGNC)
CNTFRGeneProduct1271 (Entrez Gene) CNTFR,CT-1R,ycsubunit)
CREBBPGeneProductCREBBP (HGNC)
CSF2RAGeneProductCSF2RA (HGNC)
CSF2RBGeneProductCSF2RB (HGNC)
CSF3RGeneProduct1441 (Entrez Gene) G-CSFR
CTF1GeneProductCTF1 (HGNC)
DEPTORGeneProductDEPTOR (HGNC)
DUSP2GeneProduct1844 (Entrez Gene) DUSP2
EGFRGeneProduct1956 (Entrez Gene) GM-CSFR(homodimericIL-20R,IL-22R,EGFR,PDGFR
F2RGeneProductF2R (HGNC)
F2RL2GeneProductF2RL2 (HGNC)
F2RL3GeneProductF2RL3 (HGNC)
GHRGeneProduct2690 (Entrez Gene) GHR,
IFNAR1GeneProduct3454 (Entrez Gene) IFNAR,IFNGR,
IFNAR2GeneProductIFNAR2 (HGNC)
IFNGR1GeneProductIFNGR1 (HGNC)
IFNGR2GeneProductIFNGR2 (HGNC)
IFNLR1GeneProductIFNLR1 (HGNC)
IL10RAGeneProductIL10RA (HGNC)
IL10RBGeneProductIL10RB (HGNC)
IL11RAGeneProductIL11RA (HGNC)
IL12RB2GeneProductIL12RB2 (HGNC)
IL15RAGeneProductIL15RA (HGNC)
IL20RAGeneProductIL20RA (HGNC)
IL20RBGeneProductIL20RB (HGNC)
IL21RGeneProduct50615 (Entrez Gene) IL-21R
IL22RA1GeneProductIL22RA1 (HGNC)
IL27RAGeneProduct9466 (Entrez Gene) IL-27R,IL-35R,IL-21R(sharedsubunit)
IL2RAGeneProduct3559 (Entrez Gene) IL-2R,IL-7R,
IL2RBGeneProductIL2RB (HGNC)
IL2RGGeneProductIL2RG (HGNC)
IL3RAGeneProductIL3RA (HGNC)
IL5RAGeneProductIL5RA (HGNC)
IL6RGeneProduct3570 (Entrez Gene) IL-6R,
IL6STGeneProductIL6ST (HGNC)
IL7RGeneProduct3575 (Entrez Gene) IL-7R,
IL9RGeneProduct3581 (Entrez Gene) IL-9R,
JAK1GeneProductJAK1 (HGNC)
JAK2GeneProductJAK2 (HGNC)
JAK3GeneProductJAK3 (HGNC)
LIFRGeneProduct3977 (Entrez Gene) LIFR,OSMR
MAPK10GeneProduct5602 (Entrez Gene) MAPK
MAPK11GeneProduct5600 (Entrez Gene) MAPK
MAPK12GeneProduct6300 (Entrez Gene) MAPK
MAPK13GeneProduct5603 (Entrez Gene) MAPK
MAPK14GeneProduct1432 (Entrez Gene) MAPK
MAPK1GeneProduct5594 (Entrez Gene) MAPK
MAPK15GeneProductMAPK15 (HGNC)
MAPK3GeneProduct5595 (Entrez Gene) MAPK
MAPK4GeneProductMAPK4 (HGNC)
MAPK6GeneProductMAPK6 (HGNC)
MAPK7GeneProductMAPK7 (HGNC)
MAPK8GeneProduct5599 (Entrez Gene) MAPK
MAPK9GeneProduct5601 (Entrez Gene) MAPK
MAPKAP1GeneProductMAPKAP1 (HGNC)
MLST8GeneProductMLST8 (HGNC)
MPLGeneProduct4352 (Entrez Gene) TpoR,
MTORGeneProductMTOR (HGNC)
OSMRGeneProduct9180 (Entrez Gene) OSMR
PDGFRAGeneProductPDGFRA (HGNC)
PDGFRBGeneProductPDGFRB (HGNC)
PIAS3GeneProduct10401 (Entrez Gene) PIAS3
PRKCBGeneProductPRKCB (HGNC)
PTPRCGeneProduct5788 (Entrez Gene) PTPRC
PTPRDGeneProductPTPRD (HGNC)
PTPRTGeneProduct11122 (Entrez Gene) PTPRT
RICTORGeneProductRICTOR (HGNC)
RPTORGeneProductRPTOR (HGNC)
SETD7GeneProductSETD7 (HGNC)
SOCS3GeneProduct9021 (Entrez Gene) SOCS3
SRCGeneProductSRC (HGNC)
STAT3GeneProduct6774 (Entrez Gene) STAT3
STMN1GeneProductSTMN1 (HGNC)
TRIM28GeneProductTRIM28 (HGNC)
TYK2GeneProductTYK2 (HGNC)

Annotated Interactions

No annotated interactions

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