Translation inhibitors in chronically activated PDGFRA cells (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Zhou S, Appleman VA, Rose CM, Jun HJ, Yang J, Zhou Y, Bronson RT, Gygi SP, Charest A; ''Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma.''; Life Sci Alliance, 2018 PubMed Europe PMC Scholia
2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	127382	view	19:45, 26 September 2023	Khanspers	updated phospho sites
	127254	view	17:45, 28 August 2023	Khanspers	Added literature ref and updated description
	104315	view	19:58, 16 May 2019	Khanspers	connected interaction
	103809	view	05:31, 9 April 2019	AlexanderPico	Modified title
	103808	view	05:27, 9 April 2019	AlexanderPico	Modified title
	103807	view	05:27, 9 April 2019	AlexanderPico	Modified description
	103749	view	22:21, 3 April 2019	Khanspers	labels
	103748	view	22:15, 3 April 2019	Khanspers	Modified description
	103747	view	22:15, 3 April 2019	Khanspers	Modified description
	103746	view	22:10, 3 April 2019	Khanspers	updated phosphosites
	103738	view	20:29, 2 April 2019	DeSl	Changed secondary to primary ChEBI ID for AZD8055.
	103727	view	19:55, 31 March 2019	Andra	added metabolite identifier
	103725	view	23:05, 29 March 2019	Khanspers	Ontology Term : 'glioma pathway' added !
	103724	view	23:04, 29 March 2019	Khanspers	Ontology Term : 'translation initiation pathway' added !
	103723	view	23:02, 29 March 2019	Khanspers	Modified title
	103722	view	23:01, 29 March 2019	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
4EGI-1	Metabolite	6911989 (PubChem-compound)
AKT1	GeneProduct	ENSG00000142208 (Ensembl)
AKT2	GeneProduct	ENSG00000105221 (Ensembl)
AKT3	GeneProduct	ENSG00000117020 (Ensembl)
AZD8055	Metabolite	CHEBI:91329 (ChEBI)
CSNK2A1	GeneProduct	ENSG00000101266 (Ensembl)
EIF4A1	GeneProduct	1973 (Entrez Gene)
EIF4A2	GeneProduct	1974 (Entrez Gene)
EIF4B	GeneProduct	1975 (Entrez Gene)
EIF4E	GeneProduct	1977 (Entrez Gene)
EIF4EBP1	GeneProduct	1978 (Entrez Gene)
EIF4G1	GeneProduct	1981 (Entrez Gene)	TrEMBL accession number O43177 refers to same protein.
EIF4G3	GeneProduct	8672 (Entrez Gene)
LY2584702	Metabolite
MAP2K1	GeneProduct	5604 (Entrez Gene)
MAP2K2	GeneProduct	5605 (Entrez Gene)
MAP2K3	GeneProduct	ENSG00000034152 (Ensembl)
MAP2K4	GeneProduct	ENSG00000065559 (Ensembl)
MAP2K5	GeneProduct	ENSG00000137764 (Ensembl)
MAP2K6	GeneProduct	ENSG00000108984 (Ensembl)
MAP2K7	GeneProduct	ENSG00000076984 (Ensembl)
MAPK10	GeneProduct	5602 (Entrez Gene)
MAPK14	GeneProduct	ENSG00000112062 (Ensembl)
MAPK1	GeneProduct	5594 (Entrez Gene)
MAPK3	GeneProduct	5595 (Entrez Gene)
MAPK8	GeneProduct	5599 (Entrez Gene)
MAPK9	GeneProduct	5601 (Entrez Gene)
MTOR	GeneProduct	ENSG00000198793 (Ensembl)
PDCD4	GeneProduct	ENSG00000150593 (Ensembl)
PDK1	GeneProduct	ENSG00000152256 (Ensembl)
PIK3CA	GeneProduct	ENSG00000121879 (Ensembl)
PIK3CB	GeneProduct	ENSG00000051382 (Ensembl)
PIK3CG	GeneProduct	ENSG00000105851 (Ensembl)
PIK3R1	GeneProduct	ENSG00000145675 (Ensembl)
PIK3R2	GeneProduct	ENSG00000105647 (Ensembl)
PIK3R3	GeneProduct	ENSG00000117461 (Ensembl)
PIM1	GeneProduct	ENSG00000137193 (Ensembl)
PIM2	GeneProduct	ENSG00000102096 (Ensembl)
PRKACA	GeneProduct	ENSG00000072062 (Ensembl)
PRKCA	GeneProduct	ENSG00000154229 (Ensembl)
PRKCD	GeneProduct	ENSG00000163932 (Ensembl)
RPS6	GeneProduct	ENSG00000137154 (Ensembl)
RPS6KA1	GeneProduct	ENSG00000117676 (Ensembl)
RPS6KA2	GeneProduct	ENSG00000071242 (Ensembl)
RPS6KA4	GeneProduct	ENSG00000162302 (Ensembl)
RPS6KA5	GeneProduct	ENSG00000100784 (Ensembl)
RPS6KB1	GeneProduct	ENSG00000108443 (Ensembl)
RPS6KB2	GeneProduct	ENSG00000175634 (Ensembl)
RPTOR	GeneProduct	ENSG00000141564 (Ensembl)
mRNA Translation	Pathway

Annotated Interactions

No annotated interactions