Translation inhibitors in chronically activated PDGFRA cells (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none DegradationCAP dependent translationPRKCDMAPK14PPPPRPS6PPRPS6KB1mRNA TranslationAZD8055LY25847024EGI-1PDK1RPS6KB2AKT1AKT2AKT3MTORRPTORPIM1PIM2RPS6KA4RPS6KA5PRPS6KA1RPS6KA2PDCD4EIF4A1EIF4A2MAP2K4MAP2K5MAP2K6MAP2K7PPMAP2K1PPMAP2K2PPMAPK1PPMAPK3PIK3CAPIK3CBPIK3R1PIK3R2PIK3R3PIK3CGMAPK9MAPK10MAPK8MAP2K3MAP2K6PRKCACSNK2A1PRKACARPS6EIF4EBP1EIF4EPPPPEIF4EBP1PPPPDCD4EIF4G3EIF4G1EIF4A1EIF4A2EIF4EPPEIF4BEIF4BEIF4G3EIF4G1EIF4A1EIF4A2EIF4EPPEIF4BName: Translational regulation by PDGFRαOrganism: Homo sapiens


Description

draft

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Zhou S, Appleman VA, Rose CM, Jun HJ, Yang J, Zhou Y, Bronson RT, Gygi SP, Charest A; ''Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma.''; Life Sci Alliance, 2018 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137103
Approved
view22:54, 27 February 2025KhanspersModified description
137102view22:53, 27 February 2025KhanspersModified description
134745view23:23, 26 July 2024EweitzRestore state marker positions
134744view23:20, 26 July 2024EweitzStandardize case
134743view23:19, 26 July 2024EweitzEconomize layout
127382view19:45, 26 September 2023Khanspersupdated phospho sites
127254view17:45, 28 August 2023KhanspersAdded literature ref and updated description
104315
CPTAC
view19:58, 16 May 2019Khanspersconnected interaction
103809view05:31, 9 April 2019AlexanderPicoModified title
103808view05:27, 9 April 2019AlexanderPicoModified title
103807view05:27, 9 April 2019AlexanderPicoModified description
103749view22:21, 3 April 2019Khansperslabels
103748view22:15, 3 April 2019KhanspersModified description
103747view22:15, 3 April 2019KhanspersModified description
103746view22:10, 3 April 2019Khanspersupdated phosphosites
103738view20:29, 2 April 2019DeSlChanged secondary to primary ChEBI ID for AZD8055.
103727view19:55, 31 March 2019Andraadded metabolite identifier
103725view23:05, 29 March 2019KhanspersOntology Term : 'glioma pathway' added !
103724view23:04, 29 March 2019KhanspersOntology Term : 'translation initiation pathway' added !
103723view23:02, 29 March 2019KhanspersModified title
103722view23:01, 29 March 2019KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
4EGI-1Metabolite6911989 (PubChem-compound)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AZD8055MetaboliteCHEBI:91329 (ChEBI)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
EIF4A1GeneProduct1973 (Entrez Gene)
EIF4A2GeneProduct1974 (Entrez Gene)
EIF4BGeneProduct1975 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EIF4G1GeneProduct1981 (Entrez Gene) TrEMBL accession number O43177 refers to same protein.
EIF4G3GeneProduct8672 (Entrez Gene)
LY2584702Metabolite
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K5GeneProductENSG00000137764 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MTORGeneProductENSG00000198793 (Ensembl)
PDCD4GeneProductENSG00000150593 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIM1GeneProductENSG00000137193 (Ensembl)
PIM2GeneProductENSG00000102096 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA2GeneProductENSG00000071242 (Ensembl)
RPS6KA4GeneProductENSG00000162302 (Ensembl)
RPS6KA5GeneProductENSG00000100784 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
mRNA TranslationPathway

Annotated Interactions

No annotated interactions

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