Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (Homo sapiens)

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711892Coenzyme A synthesisBPAN DiseaseFAHN DiseaseLegendPalmitoyl-CoA(R)-4'-phosphopantothenateL-cysteinesphingomyelinSPTLC13-DehydrosphinganinedihydrosphingosineD-pantetheine 4'-phosphateACACA(R)-pantothenatediphosphateceramideFA2HMECP2Coenzyme Adihydroxysphingolipids1,2-saturated fatty acid(2R)-2-hydroxy fatty acid anionL-serinedihydroceramideCOASYPANK2acetyl-CoAFe(II)-cytochrome b5malonyl-CoA3'-dephospho-CoAsphingolipidsN-[(R)-4'-Phosphopantothenoyl]-L-cysteineFe(III)-cytochrome b541356133112121641416131PIK3C3ATG10WIPI2ATG7ATG14AKT1S1ATG13RB1CC1AMPKRHEBULK1ATG16L1ATG12BECN1DEPTORLC3ATG2ALKB1ATG7PIK3R4TSC1ATG5MLST8TSC2ATG12WIPI1ATG4WDR45MTORRPTORPtdIns3PATG101ATG3ATG12ATG12ATG5LC3LC3LC3COASYCoPAN DiseasePKAN DiseaseIronLipid MetabolismFe2+Enoplasmic reticulumLysosomePLA2G6PeroxisomePantothenateMitochondrionAutophagosomeDCAF17NucleusWDR45MyelinsynthesisMembrane remodellingPLA2G6C19orf12FA2HATP13A2GTPBP2COASYPANK2FTLSCPxCoACPFe3+Lysosome / autophagosome synthesisIron homeostasisLipid metabolism and/or membrane remodellingUnknown function15


Description

Neurodegeneration with brain iron accumulation (NBIA) is an umbrella term for 12 disease subtypes, all characterized by the build-up of iron within the brain. One of these subtypes is beta-propeller protein-associated neurodegeneration (BPAN) caused by a mutation in the WDR45 gene. This protein is involved in the autophagy pathway; the exact mechanism is still unknown. Other NBIA subtypes are PKAN, CoPAN, and FAHN. PKAN and CoPAN are involved in Coenzyme A synthesis within mitochondria and FAHN is found in myelin synthesis. Dysfunctioning of these pathways leads to a phenotype characterized by developmental delay and intellectual disabilities. Nevertheless, the exact relation between mutation and phenotype remains unknown.

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Bibliography

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  1. Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T; ''WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.''; Nat Commun, 2017 PubMed Europe PMC Scholia
  2. Roach PJ; ''AMPK -> ULK1 -> autophagy.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
  3. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA; ''Structure of the human mTOR complex I and its implications for rapamycin inhibition.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  4. Catena V, Fanciulli M; ''Deptor: not only a mTOR inhibitor.''; J Exp Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  5. Memmott RM, Dennis PA; ''Akt-dependent and -independent mechanisms of mTOR regulation in cancer.''; Cell Signal, 2009 PubMed Europe PMC Scholia
  6. Huang J, Manning BD; ''The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.''; Biochem J, 2008 PubMed Europe PMC Scholia
  7. Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T; ''Architecture of human mTOR complex 1.''; Science, 2016 PubMed Europe PMC Scholia
  8. Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbe S, Clague MJ, Tooze SA; ''Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.''; Autophagy, 2010 PubMed Europe PMC Scholia
  9. Di Meo I, Tiranti V; ''Classification and molecular pathogenesis of NBIA syndromes.''; Eur J Paediatr Neurol, 2018 PubMed Europe PMC Scholia
  10. Leoni V, Strittmatter L, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V; ''Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.''; Mol Genet Metab, 2012 PubMed Europe PMC Scholia
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  13. Jung CH, Ro SH, Cao J, Otto NM, Kim DH; ''mTOR regulation of autophagy.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  14. Funderburk SF, Wang QJ, Yue Z; ''The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.''; Trends Cell Biol, 2010 PubMed Europe PMC Scholia
  15. Zachari M, Ganley IG; ''The mammalian ULK1 complex and autophagy initiation.''; Essays Biochem, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128399view03:37, 4 February 2024EweitzStandardize case
128398view03:36, 4 February 2024EweitzFix node padding, standardize case
123500view04:58, 29 July 2022EgonwMade a pathway clickable
118444view14:48, 27 May 2021Mkutmonfixed publication refs
109208view14:28, 27 February 2020Marvin M2Connected line
107175view14:26, 17 September 2019MaintBotChEBI identifier normalization
105274view21:32, 25 July 2019KhanspersModified title
104795view06:57, 18 June 2019GMKeulenChanged background color of lipid metabolism.
104775view10:32, 13 June 2019GMKeulenAdded pathway node.
104774view10:16, 13 June 2019GMKeulenAdded CheBI identifiers, changed mim-interactions to arrows.
104766view17:09, 12 June 2019GMKeulenFixed interactions within the overview figure.
104762view15:59, 12 June 2019GMKeulenAdded ensembl IDs to geneproducts
104761view15:43, 12 June 2019GMKeulenChanged text lables to geneproducts within the overview figure.
104685view11:21, 11 June 2019GMKeulenAdded literature reference for mTOR ULK1 inhibition.
104618view11:03, 4 June 2019GMKeulenAdded annotation and literature reference to PANK2 reaction.
104387view12:56, 23 May 2019GMKeulenAdded colors
104385view12:46, 23 May 2019GMKeulenAdded literature reference to figure
104384view12:44, 23 May 2019GMKeulenChanged title
104383view12:42, 23 May 2019GMKeulenAdded legend to the figure and pathway
104382view11:15, 23 May 2019GMKeulenAdded overview of different NBIA subtypes
104378view16:57, 22 May 2019GMKeulenChanged arrows to diseases
104352view09:18, 20 May 2019GMKeulenChanged names in disease lables, Corrected FA2H reaction. Added lables to the green and blue boxes.
104283view12:34, 15 May 2019FehrhartOntology Term : 'neuron' added !
104281view12:29, 15 May 2019Fehrhartgraphical fix
104207view09:00, 10 May 2019GMKeulenModified description
104064view08:24, 1 May 2019GMKeulenadded L-cysteine and diphosphate to phosphopantothenate reaction
104057view14:22, 29 April 2019GMKeulenadded MECP2 and FA2H reaction
104054view10:50, 29 April 2019GMKeulenAdded enzymatic function of FA2H
104046view06:11, 27 April 2019EgonwReplaced a secondary ChEBI ID with its primary ID.
104045view12:59, 26 April 2019GMKeulenAdded metabolites, and disease FAHN
104044view12:09, 26 April 2019GMKeulenAdded rhea identifiers, annotated metabolites and added metabolites
104041view09:08, 26 April 2019GMKeulenOntology Term : 'disease pathway' added !
104040view09:08, 26 April 2019GMKeulenOntology Term : 'neurodegeneration with brain iron accumulation' added !
104008view14:22, 25 April 2019GMKeulenchanged layout
104005view12:46, 25 April 2019GMKeulenAnnotated metabolites with chebi identifier, linked diseases to OMIM and connected reactions.
104004view12:15, 25 April 2019GMKeulenconnected AMPK
103998view08:11, 25 April 2019GMKeulenModified description
103997view08:08, 25 April 2019DeSlConnected PANK2
103996view07:58, 25 April 2019DeSlConnected CoPAN
103995view07:54, 25 April 2019DeSlChanged characters for Muller and Urbe
103994view07:51, 25 April 2019DeSlchanged character to beta.
103993view07:41, 25 April 2019DeSlConnected AMPK to group, layout change
103989view12:50, 24 April 2019GMKeulenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(2R)-2-hydroxy fatty acid anionMetaboliteCHEBI:76177 (ChEBI)
(R)-4'- phosphopantothenateMetaboliteCHEBI:10986 (ChEBI)
(R)-pantothenateMetaboliteCHEBI:29032 (ChEBI)
1,2-saturated fatty acidMetaboliteCHEBI:83955 (ChEBI)
3'-dephospho -CoAMetaboliteCHEBI:57328 (ChEBI)
3-DehydrosphinganineMetabolite17862 (ChEBI)
ACACAGeneProductENSG00000278540 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMPKGeneProductENSG00000132356 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
ATG10GeneProductENSG00000152348 (Ensembl)
ATG12GeneProductENSG00000145782 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG14GeneProductENSG00000126775 (Ensembl)
ATG16L1GeneProductENSG00000085978 (Ensembl)
ATG2AGeneProductENSG00000110046 (Ensembl)
ATG3GeneProductENSG00000144848 (Ensembl)
ATG4GeneProductENSG00000101844 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
ATP13A2GeneProductENSG00000159363 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
C19orf12GeneProductENSG00000131943 (Ensembl)
COASYGeneProductENSG00000068120 (Ensembl)
CPGeneProductENSG00000047457 (Ensembl)
Coenzyme AMetabolite57287 (ChEBI)
D-pantetheine 4'-phosphateMetaboliteCHEBI:61723 (ChEBI)
DCAF17GeneProductENSG00000115827 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
FA2HGeneProductENSG00000103089 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
Fe(II)-cytochrome b5Metabolite10438 (Rhea)
Fe(III)-cytochrome b5Metabolite10439 (Rhea)
GTPBP2GeneProductENSG00000172432 (Ensembl)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-serineMetaboliteCHEBI:33384 (ChEBI)
LC3GeneProductENSG00000101460 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
MECP2GeneProductENSG00000169057 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
N-[(R)-4'-Phospho pantothenoyl]-L-cysteineMetabolite59458 (ChEBI)
PANK2GeneProductENSG00000125779 (Ensembl)
PIK3C3GeneProductENSG00000078142 (Ensembl)
PIK3R4GeneProductENSG00000196455 (Ensembl)
PLA2G6GeneProductENSG00000184381 (Ensembl)
Palmitoyl-CoAMetabolite57379 (ChEBI)
PtdIns3PMetaboliteCHEBI:26034 (ChEBI)
RB1CC1GeneProductENSG00000023287 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
SCPxGeneProductENSG00000116171 (Ensembl)
SPTLC1GeneProductENSG00000090054 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
WDR45GeneProductENSG00000196998 (Ensembl)
WIPI1GeneProductENSG00000070540 (Ensembl)
WIPI2GeneProductENSG00000157954 (Ensembl)
acetyl-CoAMetaboliteCHEBI:57288 (ChEBI)
ceramideMetaboliteCHEBI:17761 (ChEBI)
dihydroceramideMetabolite
dihydrosphingosineMetabolite46878428 (PubChem-compound)
dihydroxysphingolipidsMetabolite
diphosphateMetabolite33019 (ChEBI)
malonyl-CoAMetaboliteCHEBI:57384 (ChEBI)
sphingolipidsMetaboliteCHEBI:26739 (ChEBI)
sphingomyelinMetaboliteCHEBI:17636 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
(R)-4'- phosphopantothenateN-[(R)-4'-Phospho pantothenoyl]-L-cysteinemim-conversion25156 (Rhea)
(R)-pantothenate(R)-4'- phosphopantothenatemim-conversion16374 (Rhea) Phosphorylation
1,2-saturated fatty acid(2R)-2-hydroxy fatty acid anionmim-conversion38855 (Rhea)
3'-dephospho -CoACoenzyme Amim-conversion18246 (Rhea)
D-pantetheine 4'-phosphate3'-dephospho -CoAmim-conversion19802 (Rhea)
N-[(R)-4'-Phospho pantothenoyl]-L-cysteineD-pantetheine 4'-phosphatemim-conversion16793 (Rhea)
Palmitoyl-CoAL-serine14761 (Rhea)
acetyl-CoAmalonyl-CoAmim-conversion18818 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4577"
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