Omega-3 / omega-6 fatty acid synthesis (Mus musculus)

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Fads2From the dietFads2Acsl1GlycerophospholipidsArachidonic acidPla2g5Pla2g6Pla2g4aPla2g4bLinoleic acidCoA(18:2(9Z,12Z))CoA(18:3(6Z,9Z,12Z))CoA(20:2(11Z,14Z))CoA(20:3(8Z,11Z,14Z))Arachidonoyl-CoAgamma-Linolenic acidCoA(22:4)CoA(24:4)20:2(11Z,14Z)Bishomo-gamma-linolenic acidCoA(22:5(4Z,7Z,10Z,13Z,16Z))alpha-Linolenic acidCoA(18:3(9Z,12Z,15Z))CoA(18:4(6Z,9Z,12Z,15Z))CoA(20:4(8Z,11Z,14Z,17Z))CoA(20:5)CoA(22:5(7Z,10Z,13Z,16Z,19Z))CoA(22:6)CoA(24:5(9Z,12Z,15Z,18Z,21Z))CoA(24:6)DHA24:6(6Z,9Z,12Z,15Z,18Z,21Z)24:5(9Z,12Z,15Z,18Z,21Z)22:5(7Z,10Z,13Z,16Z,19Z)20:5(5Z,8Z,11Z,14Z,17Z)20:4(8Z,11Z,14Z,17Z)Stearidonic acid22:5(4Z,7Z,10Z,13Z,16Z)22:4(7Z,10Z,13Z,16Z)24:4(9Z,12Z,15Z,18Z)CoA(22:2)22:2(13Z,16Z)CoA(20:3(11Z,14Z,17Z))From the diet20:3(11Z,14Z,17Z)CoA(24:5(6Z,9Z,12Z,15Z,18Z))24:5(6Z,9Z,12Z,15Z,18Z)Acls3Acls4Elovl2Elovl5Fads1Acox1Acox3Fads1Acot1Acot2Fads2Elovl2Elovl5Acsl1Acsl3Acsl4Fads2


Description

This pathway is inspired by the Lipidmaps>Omega-3 and omega-6 fatty acids) [1].

Omega-3 and omega-6 FAs (Fatty acids) are important fats obtained from diet, and are both polyunsaturated (indicating many double bonds in the lipid tail). The position of the double bond is given in the name of the lipid, for example 22:2(13Z,16Z) means a tail length of 22 carbons, with 2 double bond. One double bond is at the 13 Carbon, the second on the 16th.

This number is counted from the tail end of the lipid chain (indicating that the example lipid is a 22 - 16 = omega-6 FA).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124736view08:34, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
123513view09:46, 29 July 2022Conroy lipidsfix incorrect LM_ID on 20:2
117925view10:36, 23 May 2021EweitzModified title
110703view14:12, 28 May 2020EgonwAdded missing @Type annotation
106336view08:56, 21 August 2019DeSlAdded general LipidMaps publication.
106289view15:21, 19 August 2019DeSlOntology Term : 'fatty acid omega degradation pathway' added !
106288view15:21, 19 August 2019DeSlOntology Term : 'fatty acid metabolic pathway' added !
106283view15:10, 19 August 2019DeSlConnected unconnected line.
106282view15:09, 19 August 2019DeSlUpdate layout, connected catalysisMIM to groups iso individual enzymes, added missing enzymes.
106280view14:44, 19 August 2019DeSlModified description
106279view14:43, 19 August 2019DeSlModified description
106278view14:37, 19 August 2019DeSlModified description
106277view14:36, 19 August 2019DeSlOntology Term : 'PW:0000002' removed !
106276view14:36, 19 August 2019DeSlOntology Term : 'unsaturated fatty acid biosynthetic pathway' added !
106275view14:36, 19 August 2019DeSlOntology Term : 'fatty acid elongation pathway' added !
98613view12:56, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98580view15:56, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
20:2(11Z,14Z)MetaboliteLMFA07050036 (LIPID MAPS)
20:3(11Z,14Z,17Z)MetaboliteLMFA01030378 (LIPID MAPS)
20:4(8Z,11Z,14Z,17Z)MetaboliteLMFA01030818 (LIPID MAPS)
20:5(5Z,8Z,11Z,14Z,17Z)MetaboliteLMFA01030759 (LIPID MAPS)
22:2(13Z,16Z)MetaboliteLMFA01030405 (LIPID MAPS)
22:4(7Z,10Z,13Z,16Z)MetaboliteLMFA01030178 (LIPID MAPS)
22:5(4Z,7Z,10Z,13Z,16Z)MetaboliteLMFA04000064 (LIPID MAPS)
22:5(7Z,10Z,13Z,16Z,19Z)MetaboliteLMFA04000044 (LIPID MAPS)
24:4(9Z,12Z,15Z,18Z)MetaboliteLMFA01030819 (LIPID MAPS)
24:5(6Z,9Z,12Z,15Z,18Z)MetaboliteLMFA01030820 (LIPID MAPS)
24:5(9Z,12Z,15Z,18Z,21Z)MetaboliteLMFA01030821 (LIPID MAPS)
24:6(6Z,9Z,12Z,15Z,18Z,21Z)MetaboliteLMFA01030822 (LIPID MAPS)
Acls3GeneProduct74205 (Entrez Gene)
Acls4GeneProduct50790 (Entrez Gene)
Acot1GeneProduct26897 (Entrez Gene)
Acot2GeneProduct171210 (Entrez Gene)
Acox1GeneProduct11430 (Entrez Gene)
Acox3GeneProduct80911 (Entrez Gene)
Acsl1GeneProduct14081 (Entrez Gene)
Acsl3GeneProduct74205 (Entrez Gene)
Acsl4GeneProduct50790 (Entrez Gene)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Arachidonoyl-CoAMetaboliteLMFA07050288 (LIPID MAPS)
Bishomo-gamma-linolenic acidMetaboliteLMFA01030158 (LIPID MAPS)
CoA(18:2(9Z,12Z))MetaboliteLMFA07050343 (LIPID MAPS)
CoA(18:3(6Z,9Z,12Z))MetaboliteLMFA07050322 (LIPID MAPS)
CoA(18:3(9Z,12Z,15Z))MetaboliteLMFA07050286 (LIPID MAPS)
CoA(18:4(6Z,9Z,12Z,15Z))MetaboliteLMFA07050123 (LIPID MAPS)
CoA(20:2(11Z,14Z))MetaboliteLMFA07050036 (LIPID MAPS)
CoA(20:3(11Z,14Z,17Z))MetaboliteLMFA07050044 (LIPID MAPS)
CoA(20:3(8Z,11Z,14Z))MetaboliteLMFA07050278 (LIPID MAPS)
CoA(20:4(8Z,11Z,14Z,17Z))MetaboliteLMFA07050134 (LIPID MAPS)
CoA(20:5)MetaboliteLMFA07050122 (LIPID MAPS)
CoA(22:2)MetaboliteLMFA07050037 (LIPID MAPS)
CoA(22:4)MetaboliteLMFA07050129 (LIPID MAPS)
CoA(22:5(4Z,7Z,10Z,13Z,16Z))MetaboliteLMFA07050043 (LIPID MAPS)
CoA(22:5(7Z,10Z,13Z,16Z,19Z))MetaboliteLMFA07050131 (LIPID MAPS)
CoA(22:6)MetaboliteLMFA07050121 (LIPID MAPS)
CoA(24:4)MetaboliteLMFA07050139 (LIPID MAPS)
CoA(24:5(6Z,9Z,12Z,15Z,18Z))MetaboliteLMFA07050042 (LIPID MAPS)
CoA(24:5(9Z,12Z,15Z,18Z,21Z))MetaboliteLMFA07050141 (LIPID MAPS)
CoA(24:6)MetaboliteLMFA07050127 (LIPID MAPS)
DHAMetaboliteLMFA01030185 (LIPID MAPS)
Elovl2GeneProduct54326 (Entrez Gene)
Elovl5GeneProduct68801 (Entrez Gene)
Fads1GeneProduct76267 (Entrez Gene)
Fads2GeneProduct56473 (Entrez Gene)
From the diet
GlycerophospholipidsCHEBI:37739 (ChEBI)
Linoleic acidMetaboliteLMFA01030120 (LIPID MAPS)
Pla2g4aProtein18783 (Entrez Gene)
Pla2g4bProtein211429 (Entrez Gene)
Pla2g5Protein18784 (Entrez Gene)
Pla2g6Protein53357 (Entrez Gene)
Stearidonic acidMetaboliteLMFA01030357 (LIPID MAPS)
alpha-Linolenic acidMetaboliteLMFA01030152 (LIPID MAPS)
gamma-Linolenic acidMetaboliteLMFA01030141 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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