MAPK cascade (Homo sapiens)

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Scaffold1, 2ScaffoldRTKsNucleusStress ActivatedPathwayp38 MAPK PathwayGiGrowth and MitogenesisActivatedRap1GAPGb and GgGqMAP2K7ApoptosisMAP3K3RRASJUNNRASKRASMAPK12MBPRASA3MAP2K4GTPMAP2K6MAP3K12MAP3K2MAPK14MAP2K4PLCB3RapGAPIISIPA1MAP3K1MAP2K3GDPMAP2MAPK10HRASELK1RTKsGRB2SOS2SOS1ARAFBRAFRAF1PMAP2K1PPMAPK1PPMAPK3PPMP1MAP2K2PP


Description

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia
  2. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134171view00:49, 16 July 2024EweitzRestore phosphorylation graphics
134170view00:48, 16 July 2024EweitzIncrease font size
134169view00:46, 16 July 2024EweitzEconomize layout, standardize case
123420view06:13, 26 July 2022EgonwMade a pathway clickable
116723view10:02, 11 May 2021EweitzModified title
112162view18:28, 29 September 2020Khanspersfixed ptm state comments
112058view21:53, 17 September 2020Khanspersupdated and added ptms
108756view17:43, 28 January 2020Khansperschanged RAF complex to group
106634view20:59, 12 September 2019KhanspersModified description
105639view05:07, 10 August 2019KhanspersModified description
105252view22:31, 24 July 2019Khanspersadded phospho sites, updated layout and cell compartments
95146view03:07, 17 November 2017AlexanderPicoconnected interactions and removed extra lines
95127view15:21, 16 November 2017DeSlFixed nested groups, connected unconnected lines.
95125view15:15, 16 November 2017DeSlModified description
72129view07:53, 25 October 2013Mkutmonadded datasource to pathway datanode
71363view18:36, 17 October 2013MaintBotAutomated update of data sources
71246view20:12, 16 October 2013MaintBotAutomated update of data sources
68915view17:31, 8 July 2013MaintBotUpdated to 2013 gpml schema
67438view11:01, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
62694view21:38, 1 May 2013MaintBotupdated uniprot data source
44889view10:13, 6 October 2011MartijnVanIerselOntology Term : 'MAPK signaling pathway' added !
41059view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
38880view18:55, 24 September 2010KhanspersAdded pathway link
38879view18:53, 24 September 2010Khanspers
38831view11:56, 24 September 2010Jildaunucleus
35455view11:51, 12 February 2010MichielAdded ref
34450view18:21, 10 December 2009MaintBotAutomatic update of empty xrefs
32427view17:11, 15 August 2009MaintBotFixed text labels
32090view13:42, 14 August 2009MaintBotFixed group labels
21570view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:MAPK Cascade]] moved to [[Pathway:WP422]]: Moved to stable identifier
14694view19:37, 23 May 2008KhanspersAdded connectors
14692view19:36, 23 May 2008KhanspersPeriodical save, work in progress
13082view11:14, 17 May 2008MaintBotautomated metabolite conversion
12928view10:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
8242view13:46, 7 January 2008MaintBot[[Pathway:Human:MAPK Cascade]] moved to [[Pathway:Homo sapiens:MAPK Cascade]]: Renaming species
7741view16:14, 18 December 2007MaintBotfixed category names
7274view12:41, 4 November 2007MaintBotAdded categories to GPML
19505view22:18, 22 May 2007I.Reyesgpml file for [[Human:MAPK_Cascade]]
6349view22:18, 22 May 2007Nsalomonisgpml file for [[Human:MAPK_Cascade]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARAFGeneProductENSG00000078061 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BRAFGeneProduct673 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
GDPMetabolite146-91-8 (CAS)
GRB2GeneProduct2885 (Entrez Gene)
GTPMetabolite2564-35-4 (CAS)
HRASGeneProduct3265 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAP2GeneProduct4133 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MBPGeneProduct4155 (Entrez Gene)
MP1GeneProduct8649 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RASA3GeneProduct22821 (Entrez Gene)
RRASGeneProduct6237 (Entrez Gene)
RapGAPIIGeneProduct
SIPA1GeneProduct6494 (Entrez Gene) not confirmed SwissProt ID - mu: SPA1 MOUSE
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProduct6655 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP422"
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