Pathways of nucleic acid metabolism and innate immune sensing (Homo sapiens)
From WikiPathways
Description
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Ontology Terms
Bibliography
- Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K; ''Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
- Patterson JB, Samuel CE; ''''; , PubMed Europe PMC Scholia
- Deininger PL, Batzer MA; ''Mammalian retroelements.''; Genome Res, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
DNA replication | Pathway | WP466 (WikiPathways) | |
DNA | Q7430 (Wikidata) | ||
IRF3 | Protein | Q14653 (Uniprot-TrEMBL) | |
MAVS | Protein | Q7Z434 (Uniprot-TrEMBL) | |
MDA5 | Protein | Q9BYX4 (Uniprot-TrEMBL) | |
Nucleotide
excision repair | Pathway | WP1980 (WikiPathways) | The presence of ribonucleotides in genomic DNA enhances photodimerization of adjacent pyrimidines, which are repaired by nucleotide excision repair |
RIG-I | Protein | ||
RNase H2 subunit A | Protein | O75792 (Uniprot-TrEMBL) | Catalytic subunit |
RNase H2 subunit B | Protein | Q5TBB1 (Uniprot-TrEMBL) | Noncatalytic subunit |
RNase H2 subunit C | Protein | Noncatalytic subunit | |
Retroelement | Q1473344 (Wikidata) | ||
SAMHD1 | Protein | Q9Y3Z3 (Uniprot-TrEMBL) | |
STING | Protein | Q86WV6 (Uniprot-TrEMBL) | |
TMEM173 | GeneProduct | cGAS which signals via STING (encoded by TMEM173) | |
TREX1 | Protein | Q9NSU2 (Uniprot-TrEMBL) | Cytosolic deoxyribonuclease anchored in the outer nuclear membrane. A lack of TREX1 causes DNA accumulation, both within the nucleus and the cytosol. |
cDNA | Q283478 (Wikidata) | Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. | |
cGAS | Protein | Q8N884 (Uniprot-TrEMBL) | DNA sensor |
dN | Metabolite | 18274 (ChEBI) | |
dNTP pools | Metabolite | 46149 (ChEBI) | |
dsDNA | Q55978910 (Wikidata) | ||
mRNA | Q188928 (Wikidata) | ||
ssDNA | Q10906438 (Wikidata) | single-stranded DNA |
Annotated Interactions
Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
dNTP pools | dN | mim-conversion | 46149 (Rhea) | SAMHD1 degrades deoxynucleoside triphosphates (dNTP) |