Ketogenesis and ketolysis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Newman JC, Verdin E; ''β-Hydroxybutyrate: A Signaling Metabolite.''; Annu Rev Nutr, 2017 PubMed Europe PMC Scholia
2. Noebels JL, Avoli M, Rogawski MA, Olsen R, Delgado-Escueta A; ''Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.''; https://www.ncbi.nlm.nih.gov/books/NBK98219/figure/masino.f1/; National Center for Biotechnology Information (US), 2012
3. Olson AL, Pessin JE; ''Structure, function, and regulation of the mammalian facilitative glucose transporter gene family.''; Annu Rev Nutr, 1996 PubMed Europe PMC Scholia
4. Sharpe AJ, McKenzie M; ''Mitochondrial Fatty Acid Oxidation Disorders Associated with Short-Chain Enoyl-CoA Hydratase (ECHS1) Deficiency.''; Cells, 2018 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	122056	view	13:30, 9 March 2022	SamDrabbe	Pathway annotation ketogenesis adjusted
	119118	view	08:48, 18 June 2021	Finterly	Added ISBN for book citation
	117768	view	13:29, 22 May 2021	Eweitz	Modified title
	108452	view	13:56, 20 December 2019	DeSl	Ontology Term : 'glial cell' added !
	108451	view	13:55, 20 December 2019	DeSl	Ontology Term : 'PW:0000002' removed !
	108450	view	13:55, 20 December 2019	DeSl	Ontology Term : 'ketone bodies degradation pathway' added !
	108449	view	13:54, 20 December 2019	DeSl	Ontology Term : 'ketone bodies metabolic pathway' added !
	108448	view	13:54, 20 December 2019	DeSl	Modified description
	108447	view	13:49, 20 December 2019	DeSl	Updated right side of PW.
	108446	view	13:25, 20 December 2019	DeSl	Updated middle part
	108445	view	13:03, 20 December 2019	DeSl	Started updating lefthand side of PW
	107929	view	21:23, 11 November 2019	Khanspers	connected interaction
	107914	view	10:03, 10 November 2019	Egonw	Missed one sec ChEBI ID :(
	107911	view	09:14, 10 November 2019	Egonw	Better representation for mediated translocations.
	107910	view	09:07, 10 November 2019	Egonw	Fixed two interactions, which are not conversions.
	107909	view	09:03, 10 November 2019	Egonw	Replaced secondary ChEBI identifiers with a primary identifiers.
	107901	view	19:32, 9 November 2019	RGrosmanC	Ontology Term : 'neuron' added !
	107900	view	19:32, 9 November 2019	RGrosmanC	Ontology Term : 'hepatocyte' added !
	107899	view	19:31, 9 November 2019	RGrosmanC	Ontology Term : 'classic metabolic pathway' added !
	107898	view	19:30, 9 November 2019	RGrosmanC	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ACA	Metabolite	CHEBI:15344 (ChEBI)	ACA aka Acetoacetate
ACAT2	GeneProduct	ENSG00000120437 (Ensembl)
ATP	Metabolite	CHEBI:15422 (ChEBI)
Acetoacetate	Metabolite	CHEBI:15344 (ChEBI)
Acetoacetyl-CoA	Metabolite	CHEBI:15345 (ChEBI)
Acetyl-CoA	Metabolite	CHEBI:15351 (ChEBI)
BDH1	GeneProduct	ENSG00000161267 (Ensembl)
BHIB	Metabolite	CHEBI:17066 (ChEBI)
CAT	Protein	O43772 (Uniprot-TrEMBL)	CAT aka carnitine translocase
CO2	Metabolite	CHEBI:16526 (ChEBI)
CPT1C	GeneProduct	ENSG00000169169 (Ensembl)
FAO	Pathway	WP143 (WikiPathways)
FA	Metabolite	Q61476 (Wikidata)
Fatty acids (FA)	Metabolite	Q61476 (Wikidata)
Gluconeogenesis	Pathway	WP4740 (WikiPathways)
Gycolysis	Pathway	WP4277 (WikiPathways)
Ketogenesis	Pathway	WP4741 (WikiPathways)
Mitochondrial LC-Fatty Acid Beta-Oxidation	Pathway	WP368 (WikiPathways)
OXCT1	GeneProduct	ENSG00000083720 (Ensembl)
Oxaloacetate	Metabolite	CHEBI:30744 (ChEBI)
SLC16A1	GeneProduct	ENSG00000155380 (Ensembl)
SLC2A1	GeneProduct	ENSG00000117394 (Ensembl)
TCA (Krebs)cycle	Pathway	WP78 (WikiPathways)
UCP2	GeneProduct	ENSG00000175567 (Ensembl)
acetone	Metabolite	CHEBI:15347 (ChEBI)
glucose	Metabolite	CHEBI:17234 (ChEBI)
pyruvate	Metabolite	CHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions